Document text
Principal Investigator: Jessica L. Krok-Schoen
Organization: OHIO STATE UNIVERSITY
Fiscal Year: 2024
Award: $196,875
Funding agency: National Institute on Aging
ABSTRACT
Accounting for more than 60% of cancer survivors, older (≥65 years) cancer survivors, have a 2- to 5-fold risk of
physical function impairment, compared to cancer-free controls. Physical function impairment has multiple
deleterious health effects including poor health-related quality of life (HRQoL), multi-morbidity, increased falls,
and all-cause mortality. One strategy to improve physical function is dietary and resistance training interventions,
which improve muscle strength and mass by stimulating muscle protein synthesis. However, there are no
synchronous, online diet and exercise interventions for older cancer survivors, a group at high risk for functional
limitations. Thus, the E-PROOF (E-intervention for Protein Intake and Resistance Training to Optimize Function)
study will examine the feasibility, acceptability, and preliminary efficacy of a 12-week randomized controlled trial
of an online, tailored nutritional and resistance training education and counseling intervention to improve physical
function and associated health outcomes (muscle strength, HRQoL, self-efficacy, and weight management). We
postulate that, compared to the control group, intervention participants would experience statistically significant,
clinically meaningful improvements in physical function and associated health outcomes following the 12-week
diet and resistance training intervention. To achieve our objective, we will: 1) Determine the feasibility and
acceptability of implementing an online dietary and resistance training intervention among 70 older cancer
survivors; and; 2) Examine the preliminary efficacy of an online dietary and resistance training intervention to
improve physical function and associated outcomes among 70 older cancer survivors who participated in a 12-
week intervention. In this pilot randomized controlled trial, participants will be randomized to one of two groups:
one experimental (online counseling by a registered dietitian and exercise scientist, menus, educational
materials on protein, healthy diet, resistance training) and one control (general survivorship education). We will
examine the intervention effects on physical function, muscle strength, HRQoL, self-efficacy, weight, and waist
circumference during a 12-week period between the experimental and control groups. We will conduct a 3-month
follow-up to assess physical function, muscle strength, and HRQoL. The feasibility of conducting an online diet
and resistance training intervention in older cancer survivors will be determined by the study accrual, retention,
and adherence rates. This study will inform the development of a R01 scale randomized controlled trial to
evaluate the effectiveness of a protein-focused meal delivery program and resistance exercise regimen on risk
for functional impairment and sarcopenia among older cancer survivors. The study goals respond to the NIA and
NCI missions to address the research gaps in older cancer survivors and help them lead longer, healthier lives.
This novel study advances science by promoting independent health behaviors among older cancer survivors,
which can improve health outcomes and provide foundational knowledge to further address this growing problem
on a wider scale through online platforms.
Terms: <65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Accounting><Active Follow-up><Address><Adherence><Age><Aged 65 and Over><Aging><Arthritis><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 exposure><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Calories><Cancer Intervention><Cancer Patient><Cancer Survivor><Cancer Survivorship><Cancers><Cardiac Chronotropism><Cardiac Diseases><Cardiac Disorders><Clinical><Comprehensive Cancer Center><Conditioning Therapy><Consumption><Control Groups><Counseling><Coupled><Data><Development><Diet><Dietary Intervention><Dietary intake><Dietitian><Education><Education and Training><Education for Intervention><Educational Intervention><Educational Materials><Educational aspects><Exercise><Exercise routine><Fatigue><Functional impairment><Geriatrics><Goals><Health><Health Care Costs><Health Costs><Health Promotion><Health behavior><Healthcare Costs><Healthy diet><Heart Diseases><Heart Rate><History><Impairment><Incidence><Instruction Intervention><Intake><Intervention><Intervention Strategies><Knowledge><Lack of Energy><Lead><Lung Diseases><Malignant Neoplasms><Malignant Tumor><Mission><Muscle Atrophy><Muscle Proteins><Muscular Atrophy><Nutrition Interventions><Nutritional><Nutritional Interventions><Obesity><Ohio><Outcome><Outcome Study><Pain><Painful><Participant><Pb element><Physical Function><Physical assessment><Population><Predisposition><Prevalence><Process><Protein Biosynthesis><Proteins><Public Health><Pulmonary Diseases><Pulmonary Disorder><Randomization trial><Randomized><Randomized, Controlled Trials><Recommendation><Recording of previous events><Research><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Risk Reduction><SARS-CoV-2 epidemic><SARS-CoV-2 exposure><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 exposure><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Salutogenesis><Sampling><Science><Scientist><Self Efficacy><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 exposure><Severe acute respiratory syndrome coronavirus 2 pandemic><Susceptibility><Testing><Training Intervention><Training and Education><Universities><Weight><Weight maintenance regimen><Work><above age 65><acceptability and feasibility><active followup><adherence rate><adiposity><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><arthritic><assess effectiveness><balanced diet><behavior change><behavior intervention><behavioral intervention><co-morbid><co-morbidity><comorbidity><compare to control><comparison control><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 exposure><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><corpulence><delivered on-line><delivered online><design><designing><determine effectiveness><determine efficacy><developmental><diet 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disorder><malignancy><mortality><multimorbidity><multiple chronic conditions><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle strength><muscle wasting><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><nutritious><old age><older adult><older adulthood><on-line delivery><online delivery><over 65 years><peer><physical activity intervention><post intervention><prevent><preventing><programs><promoting health><protein intake><protein synthesis><randomisation><randomization><randomized control trial><randomized trial><randomly assigned><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistance exercise><resistance training><retention rate><retention strategy><risk-reducing><sarcopenia><sarcopenic><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><survivorship><waist circumference><web based delivery><weight control><weight management><weights><≥65 years>