TNFR-Nicotinic Signaling in COVID-19

NIH Pandemic-Era Grants

Pandemic Era Grants

2020

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Principal Investigator: Ian  Myles
Organization: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Fiscal Year: 2020
Award: $12,447
Funding agency: National Institute of Allergy and Infectious Diseases

Alterations in ACE2 caused by the SARSCoV2 infection are preventing proper functioning of TACE  leading to an increase in membrane bound TNF and/or TNFR2 retention subsequently local hyperproliferation and ECM deposition or alterations in the nicotinic acetylcholine receptor. Perhaps a treatment targeted at TNFR2 or nAChR could provide therapeutic benefit in COVID19 patients. Will also longitudinally stratifying cytokine concentrations by severity will provide additional insights that may suggest immune modulatory targets for COVID patients, even if no abnormality in TNFR balance is detected.

Terms: <(TNF)-α><2019 novel coronavirus><2019-nCoV><Assay><Bioassay><Biologic Assays><Biological Assay><Blood Serum><CD 120a Antigen><CD120a Antigens><COVID><COVID-19><COVID19><Cachectin><Cachectin Receptors><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><CoV disease><Deposit><Deposition><ECM><Equilibrium><Extracellular Matrix><Human><Immune><Immunes><Infection><Infection prevention><Intracellular Communication and Signaling><Macrophage-Derived TNF><Membrane><Modern Man><Monocyte-Derived TNF><Nicotine><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Patients><Prevent infection><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Sampling><Serum><Severe acute respiratory syndrome coronavirus 2><Severities><Signal Transduction><Signal Transduction Systems><Signaling><TNF><TNF A><TNF Alpha><TNF Receptor Family Protein><TNF Receptor Superfamily><TNF Receptor p55><TNF Receptors><TNF gene><TNF-sR55><TNF-α><TNF-α receptor><TNFA><TNFAR><TNFBR><TNFR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR2><TNFR55><TNFR60><TNFR80><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFRSF1B><TNFRSF1B gene><TNFalpha receptor><TNFα><TNFα receptor><Therapeutic><Tumor Necrosis Factor><Tumor Necrosis Factor Beta Receptor><Tumor Necrosis Factor Receptor><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Necrosis Factor Receptor Family><Tumor Necrosis Factor Receptor Superfamily><Tumor Necrosis Factor-alpha><Wuhan coronavirus><balance><balance function><biological signal transduction><clinical center><corona virus disease><corona virus disease 2019><coronavirus disease><coronavirus disease 2019><cytokine><insight><membrane structure><therapeutic target><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor receptor superfamily, member 1B><tumor necrosis factor α receptor>