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Principal Investigator: Bethany B. Moore
Organization: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Fiscal Year: 2024
Award: $839,331
Funding agency: National Heart Lung and Blood Institute
The overarching theme for our research program over the past 20 years has been to better understand the
etiology and pathogenesis of lung injury, repair and remodeling, with a particular interest in how the immune
response shapes pathologic and homeostatic processes in the lung. Our laboratory has contributed seminal
studies related to 1) chemokine-mediated angiogenesis in cancer and lung fibrosis, 2) eicosanoid regulation of
lung fibrosis, 3) eicosanoid regulation of innate immunity in the setting of hematopoietic stem cell
transplantation (HSCT), 4) chemokine regulation of lung fibrosis, 5) fibrocyte functions in lung fibrosis, 6)
matricellular protein regulation of lung fibrosis, 7) proteomic, microbiome and other biomarker studies in lung
fibrosis, 8) role of viral infections in “idiopathic” lung fibrosis, 9) role of viral infections in mediating pneumonitis
and fibrosis post-HSCT and 10) studies of secondary bacterial infection post-influenza. Our work has utilized
animal models to carry out mechanistic studies and has utilized patient-derived materials to confirm relevant
pathways, identify therapeutic targets and characterize novel biomarkers. Based on our previously published
observations and novel preliminary data, our laboratory is broadly focused in 4 main areas. The first is to study
innate immune signaling in regulation of secondary bacterial infections post-influenza. The second is to explore
interactions between the lung microbiome and innate signaling receptors in the pathogenesis of lung fibrosis.
The third is to explore the role of myeloid-specific heparin-binding epidermal-like growth factor (HB-EGF)
signaling in regulation of lung fibrosis. The fourth is to further understand the viral etiology and pathogenesis
of lung pneumonitis and fibrosis as a complication of HSCT. This outstanding investigator award mechanism
will allow us to extend our studies in each of these areas and will allow for mechanistic understanding of the
role of immune signaling in the pathogenesis of fibrosis, pneumonitis and lung injury, especially following viral
infection. It will also allow our laboratory to complete proof of concept and validation studies needed in both
animals and humans to advance new therapies to the clinics for treatment of lung diseases.
Terms: <Animal Model><Animal Models and Related Studies><Animals><Area><Award><Bacterial Infections><Biological Markers><Cancers><Causality><Cell Communication and Signaling><Cell Signaling><Chemotactic Cytokines><Clinic><Complication><Data><Disease><Disorder><Eicosanoids><Etiology><Fibrosis><Grippe><Growth Agents><Growth Factor><Growth Substances><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Heparin Binding><Herpes infection><Herpesviridae Infections><Herpesviridae disease><Herpesvirus Infections><Homologous Chemotactic Cytokines><Human><Immune response><Immune signaling><Immunobiology><Immunologic Receptors><Immunological Receptors><Immunological response><Immunophysiology><Influenza><Innate Immunity><Intercrines><Intracellular Communication and Signaling><Investigators><Laboratories><Lung><Lung Diseases><Lung Inflammation><Lung Respiratory System><Lung Tissue Fibrosis><Lung damage><Malignant Neoplasms><Malignant Tumor><Mediating><Modern Man><Myelogenous><Myeloid><Myeloid Cells><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Pathogenesis><Pathologic><Pathway interactions><Patients><Pneumonitis><Process><Production><Progenitor Cell Transplantation><Proteins><Proteins Growth Factors><Proteomics><Publishing><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Fibrosis><Pulmonary Inflammation><Receptor Signaling><Regulation><Research><Research Personnel><Researchers><Role><SIS cytokines><Seminal><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Transplantation><Stem cell transplant><Viral><Viral Diseases><Virus Diseases><Work><angiogenesis><bacteria infection><bacterial disease><bio-markers><biologic marker><biological signal transduction><biomarker><causation><chemoattractant cytokine><chemokine><co-infection><coinfection><disease causation><disease of the lung><disorder of the lung><fibrosis in the lung><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><heparin bound><heparin-binding EGF-like growth factor><host response><immune receptor><immune system response><immunoresponse><interest><lung disorder><lung fibrosis><lung injury><lung microbiome><malignancy><microbiome><model of animal><neoplasm/cancer><new drug treatments><new drugs><new marker><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel biomarker><novel drug treatments><novel drugs><novel marker><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pneumonitis and fibrosis><progenitor transplantation><programs><pulmonary><pulmonary damage><pulmonary injury><pulmonary microbiome><pulmonary tissue damage><pulmonary tissue injury><repair><repaired><social role><stem and progenitor cell transplantations><therapeutic target><validation studies><viral infection><virus infection><virus-induced disease>