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Principal Investigator: STEFAN FESKE
Organization: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
Fiscal Year: 2024
Award: $21,000
Funding agency: National Institute of Allergy and Infectious Diseases
SUMMARY
This proposal requests funds to support the FASEB Science Research Conference (SRC) on "Channels and
Transporters in Immunity" (CTI) that will be held from June 14–20, 2024 in St. Paul, MN. FASEB SRCs are
one of the leading conference series that bring together scientists from all over the world who are experts in a
specific research area to present and discuss their latest and most important research. This will be the first
FASEB SRC on this particular topic and the most significant meeting of the year on this topic. The only other
multi-day conference in the CTI field took place in 2021 and was attended by more than 150 participants, both
virtually and in person. The current FASEB conference, organized by the same team, builds on the success of
the 2021 meeting and aims at establishing a recurring venue for scientists in the fields of immunology,
physiology, biophysics, structural biology and cell biology. Effective immune responses to infection or tissue
damage rely on the ability of immune cells to rapidly respond to stimuli. Several channels and transporters
(C&Ts) have emerged to be important control switches that shape immunological and inflammatory responses
during infection, cancer and autoimmunity. Mutations in some of these channels have been linked to
immunodeficiency in rare populations of human patients. Nevertheless, we know very little about the function of
the vast majority of the hundreds of C&Ts that are expressed in immune cells. Major gaps in our current
knowledge include a mechanistic understanding of how ion fluxes regulate immune responses at the cellular and
organismal level. This is a clearly missed opportunity for our basic understanding of immunology as well as its
clinical applications. As a result, there are currently no FDA–approved drugs targeting C&Ts for immunological
disorders. Clinical areas that would benefit from a better understanding of the role of ICTs in immune cells include
asthma/allergy, autoimmune diseases, antitumor immunity and immunity to infection. The FASEB SRC on
"Channels and Transporters in Immunity" will provide a unique and novel opportunity for scientists from different
fields that typically do not interact to discuss the latest advances in the regulation, function and physiological
roles of ICTs in innate and adaptive immunity. The purpose of this conference therefore is nothing less than to
invigorate the entire field of C&Ts in immunology and to ignite broad interest among academic labs and
pharmaceutical companies to develop drugs targeting C&Ts for the treatment of immunological diseases. The
specific aims of the symposium are to (1) Discuss cutting-edge science in the ion channel and immunology fields
and promote opportunities for new interdisciplinary collaborations; (2) Facilitate the translation of basic
knowledge into pre-clinical explorations and clinical initiatives; (3) Provide presentation, networking and career-
development opportunities for trainees including students, postdocs and junior faculty; and (4) Increase the
number of women, under-represented minorities (URMs) and disabled individuals in this field.
Terms: <Advisory Committees><Allergy><Anxiety><Area><Arrhythmia><Asthma><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Basic Research><Basic Science><Biophysics><Body Tissues><Bronchial Asthma><Cancers><Cardiac Arrhythmia><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular biology><Clinical><Collaborations><Communities><Dedications><Degenerative Neurologic Disorders><Development><Disabled Persons><Disabled Population><Disease><Disorder><Drug Targeting><Epilepsy><Epileptic Seizures><Epileptics><Event><FDA approved><Faculty><Female><Funding><Genes><Genetic Alteration><Genetic Change><Genetic defect><Goals><Handicapped><Heart Arrhythmias><Heart Vascular><History><Human><Hypersensitivity><Hypertension><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Modulation Therapy><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunity><Immunochemical Immunologic><Immunodeficiency and Immunosuppression Disorders><Immunologic><Immunologic Diseases><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunological response><Immunologically><Immunologics><Immunologist><Immunology><Immunomodulation><Individuals from minority><Individuals of minority><Infection><Inflammation><Inflammatory Response><Innate Immunity><Intermediary Metabolism><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Ions><Knowledge><Language><Link><Malignant Neoplasms><Malignant Tumor><Membrane Channels><Membrane Transport><Metabolic Processes><Metabolism><Methods><Minority><Minority Groups><Minority People><Minority Population><Minority individual><Modern Man><Modernization><Mutation><Myelogenous><Myeloid><Native Immunity><Natural Immunity><Nervous System><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Organ System><Non-Specific Immunity><Nonspecific Immunity><Organ><Pain><Painful><Participant><Pathologic><Patients><People with Disabilities><Persons><Persons with Disabilities><Phagocytes><Phagocytic Cell><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Physiologic><Physiological><Physiology><Population><Postdoc><Postdoctoral Fellow><Recording of previous events><Recurrence><Recurrent><Regulation><Request for Proposals><Research><Research Associate><Role><Schedule><Science><Scientist><Seizure Disorder><Sepsis><Series><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Students><Task Forces><Techniques><Therapeutic><Tissues><Translating><Translations><Transmembrane Transport><Tumor Immunity><Underrepresented Ethnic Minority><Underrepresented Minority><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Woman><adaptive immunity><advisory team><amebocyte><anti-tumor immunity><antitumor immunity><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><blood infection><bloodstream infection><cancer immunity><career development><cell biology><cell type><circulatory system><clinical applicability><clinical application><conference><convention><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><demographics><design><designing><developmental><disabled individual><disabled people><drug discovery><epilepsia><epileptogenic><frontier><genome mutation><high blood pressure><histories><host response><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><hypoimmunity><immune deficiency><immune modulating therapies><immune modulation><immune modulatory therapies><immune regulation><immune system response><immune-modulation treatment><immunodeficiency><immunologic reactivity control><immunomodulation therapy><immunomodulation treatment><immunomodulator therapies><immunomodulator treatment><immunomodulator-based therapies><immunomodulatory><immunomodulatory therapies><immunomodulatory therapy><immunomodulatory treatment><immunoregulation><immunoregulatory><immunoresponse><individuals with disabilities><innovate><innovation><innovative><interdisciplinary collaboration><interest><male><malignancy><meeting><meetings><neglect><neoplasm/cancer><neural inflammation><neurodegenerative illness><neuroinflammation><neuroinflammatory><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathogen><pharmaceutical><pharmacologic><post-doc><post-doctoral><post-doctoral trainee><posters><pre-clinical><pre-clinical study><preclinical><preclinical study><research associates><social role><structural biology><success><summit><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transdisciplinary collaboration><translation><translation strategy><translational approach><translational investigator><translational researcher><translational scientist><translational strategy><under-representation of minorities><under-represented minority><underrepresentation of minorities><virtual><zinc binding ligand><zinc transporter><zinc-binding protein>