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Principal Investigator: Karen Marie Dobos
Organization: COLORADO STATE UNIVERSITY
Fiscal Year: 2022
Award: $3,193,195
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary / Abstract
The funding and implementation of this supplement is essential to maintain uninterrupted research and
scholarly activity in CSU’s Rocky Mountain Regional Biocontainment Laboratory (RMRBL). Research
activities that occur at the RMRBL directly address the RBLs’ missions to respond to and prevent global
infectious disease threats. Our efforts are the evolution of over 4 decades of research conducted at CSU
predominately sponsored by NIAID, and includes interdisciplinary research teams studying Flaviviridae,
Togaviridae, Bunyavirales, Coronaviridae viral pathogens along with robust programs in mycobacteria,
anti microbial resistance, and vector borne bacterial pathogens. The RBL is integral for this infectious
disease research, training and other scholarly activities. The RMRBL recently benefitted from a G20
award specific to much needed modernization and infrastructure upgrades. However, these investments
continue to be needed due to the complexity and high use of this facility. Here, we add to the Specific
Aims of our parent G20 award to continue to make critical investments to improve our biosafety, animal
modeling, and imaging research needs.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Air><Air Conditioning><Air Movements><American><Animal Husbandries><Animal Husbandry><Animal Model><Animal Models and Related Studies><Animal Welfare><Animals><Antimicrobial Resistance><Antimicrobial resistant><Area><Automation><Avian Influenza><Award><Bears><Biologic Models><Biological Models><Biological Terrorism><Bioterrorism><Bird Flu><Bunyavirales><CDC><COVID-19><COVID-19 virus><COVID19><COVID19 virus><CV-19><CV19><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical Treatment Moab><CoV-2><CoV2><Collaborations><Colorado><Communicable Diseases><Complex><Containment><Coronaviridae><Coronavirus><Dengue><Diagnosis><Disease><Disorder><Domestic Animals><Domestic Rabbit><Educational process of instructing><Educational workshop><Emergencies><Emergency Situation><Emerging Communicable Diseases><Emerging Infectious Diseases><Ensure><Equipment><Event><Evolution><Fellowship><Ferrets><Flaviviridae><Fowl Pest><Fowl Plague><Funding><Genus Mycobacterium><Grant><Heating><Hydrogen Oxide><Image><In Vitro><Individual><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Investments><Knowledge><Laboratories><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Maintenance><Malaria><Mice><Mice Mammals><Microscopic><Mission><Model System><Modeling><Modernization><Molecular><Monoclonal Antibodies><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Mycobacterium><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><NCI Scholars Program><NIAID><National Institute of Allergy and Infectious Disease><Organism><Oryctolagus cuniculus><Paludism><Parents><Performance><Plasmodium Infections><Prevention><Public Health><Rabbits><Rabbits Mammals><Research><Research Activity><Research Personnel><Research Resources><Research Support><Research Training><Researchers><Resistance to antimicrobial><Resources><Rodent><Rodentia><Rodents Mammals><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Safety><Scholars Program><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Social Support System><Sterility><Sterilization><Support System><System><TB infection><Teaching><Temperature><Therapeutic><Time><Togaviridae><Togaviruses><Training><Tuberculosis><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Universities><Update><Ursidae><Ursidae Family><Vaccines><Virulent><Water><Work><Workshop><Wuhan coronavirus><ZIKV><Zika Virus><air flow><airflow><animal care><anti-microbial resistance><anti-microbial resistant><avian flu><bacteria pathogen><bacterial pathogen><base><bear><biodefense><conference><convention><corona virus><corona virus disease 2019><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><cost><design><designing><disseminated TB><disseminated tuberculosis><domesticated animal><emerging pathogen><hCoV19><imaging><improved><in vivo><infection due to Mycobacterium tuberculosis><influenza in birds><living system><mAbs><model of animal><model organism><nCoV2><new pathogen><novel pathogen><operation><pathogen><pathogenic bacteria><pathogenic virus><prevent><preventing><programs><repair><repaired><research facility><resistance to anti-microbial><resistant to anti-microbial><resistant to antimicrobial><response><spillover event><sterile><success><summit><symposia><symposium><synergism><tuberculosis infection><tuberculous spondyloarthropathy><vector-borne><vectorborne><ventilation><viral pathogen><virus pathogen><visiting scholar><zikav>