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Principal Investigator: ELIZABETH S BURNSIDE
Organization: UNIVERSITY OF WISCONSIN-MADISON
Fiscal Year: 2024
Award: $8,885,006
Funding agency: National Center for Advancing Translational Sciences
Contact PD/PI: Brasier, Allan
OVERALL ABSTRACT. This application is for renewal for the Clinical and Translational Science Award
(CTSA) at the University of Wisconsin-Madison (UW) Institute for Clinical and Translational Research (ICTR).
Through meaningful collaborations with partnering schools and our “spoke” organization, Marshfield Clinic
Research Institute, we expand support and innovation to accelerate clinical and translational research (CTR)
across our Hub. Over the past funding period, our KL2 scholars have successfully competed for $131M in
extramural funding. Our evidence-based CTR mentorship trained 501 master facilitators in 51 CTSAs. We
engaged regional networks in 90% of the counties in Wisconsin. Recently, ICTR led multiple impactful mid-
course corrections enabling our students, staff, and scientists to effectively address health inequities revealed
by the COVID-19 pandemic. Building on user needs assessments, SWOT analyses, and institute-wide
strategic planning we developed an Innovation Scorecard that serves as a roadmap to use continuous
improvement to address ongoing challenges in conducting efficient, rigorous, and engaged CTR. Our
application addresses 5 impactful Aims aligned with objectives in our Innovation Scorecard, each testing
explicit hypotheses. These Aims are: 1) Expand skills, efficacy, and resiliency of the CTR workforce to
engage effectively in multidisciplinary approaches to CTR. We test an eco-systems approach to promote
trainee resiliency, and propose to enhance academic recognition of clinical research, mentorship, and team
science. 2) Use bidirectional community engagement and inclusion training for increased involvement
of historically underrepresented groups in CTR leading to improved health equity. We will test whether
incorporating innovative stakeholder engagement, dissemination and implementation, and team science
approaches improve the fidelity and sustainability of interventions in health systems and communities. 3)
Employ intentional, systems-level change strategies to break barriers in diversity, equity, and inclusion
leading to a campus culture of “inclusive excellence.” We test evidence-based interventions on workforce
diversity and ability of translational reams to engage historically underrepresented groups in CTR. 4) Support
a sustainable informatics ecosystem to transform data to knowledge, enhance integration of research
into health care delivery, and promote rigor and reproducibility in CTR. We will provide and support
secure data sharing, interoperable systems, disease-focused registries and well-trained informaticians to
advance data-driven CTR. 5) Integrate a “concept-to-closure” support model for clinical research
engaging UW Health regional and national networks. We integrate support for CTR within UW Health. We
will test whether communities of practice for clinical trialists will enhance our CTR capacity. ICTR’s broad
reach, experienced leadership, high-functioning infrastructure, and partnerships will enable us to advance
translational science as a rigorous discipline, providing disruptive innovations in CTR.
Project Summary/Abstract Page 271
Contact PD/PI: Brasier, Allan
OVERALL
Terms: <Abbreviations><Acceleration><Address><Adopted><Adoption><Bibliography><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><Clinic><Clinical Research><Clinical Study><Clinical and Translational Science Awards><Collaborations><Communities><Community of Practice><Coronavirus Infectious Disease 2019><County><Data><Data Science><Data Systems><Development><Dimensions><Discipline><Disease><Disorder><Dissemination and Implementation><EXTMR><Ecologic Systems><Ecological Systems><Ecosystem><Electronics><Engineering><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Evidence based intervention><Extramural><Extramural Activities><Faculty><Funding><Generalized Growth><Growth><Health><Health Inequity><Health Informatics><Health system><Healthcare><Healthcare Delivery><Human Resources><IT Systems><Individual><Individuals from minority><Individuals of minority><Inequalities in Health><Inequities in Health><Informatics><Information Systems><Information Technology Systems><Infrastructure><Institution><Intervention><Intervention Strategies><Investigators><Leadership><Manpower><Mentors><Mentorship><Methods><Minority Groups><Minority People><Minority Population><Minority individual><Modeling><NCATS><National Center for Advancing Translational Sciences><Needs Assessment><Patient Recruitments><Pharmacy Schools><Position><Positioning Attribute><Public Health><Public Health Informatics><Registries><Reproducibility><Research><Research Institute><Research Personnel><Researchers><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><School Health Nursing><School Nursing><Schools><Science><Scientist><Secure><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Speed><Strategic Planning><Students><System><Testing><Tissue Growth><Training><Translational Research><Translational Science><Trust><Underrepresented Groups><Underrepresented Populations><Universities><Veterinary Medicine><Veterinary Schools><Wisconsin><Workforce Development><anti-racism><anti-racist><clinical practice><collaboration with communities><college><collegiate><community collaboration><community engagement><community-based collaboration><consumer informatics><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><data interoperability><data into knowledge><data sharing><data to knowledge><design><designing><developmental><dissemination science><diversity, equity, and inclusiveness><effective intervention><electronic><electronic device><empowerment><engagement with communities><equity, diversity, and inclusion><ethnic subgroup><ethnicity group><evidence base><experience><health and care delivery><health care><health care delivery><health delivery systems><health equity><health inequalities><health services delivery><health training><implementation science><improved><innovate><innovation><innovative><interdisciplinary approach><interoperability><interventional strategy><medical college><medical schools><multidisciplinary approach><novel><ontogeny><participant recruitment><personnel><resilience><resilient><school of medicine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><success><systemic intervention><translation research><translational engagement><translational investigation><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><work group><working group>