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Principal Investigator: Jarett D Berry
Organization: UNIVERSITY OF TEXAS HLTH CTR AT TYLER
Fiscal Year: 2024
Award: $114,873
Funding agency: National Heart Lung and Blood Institute
PROJECT SUMMARY (30 lines)
Dr. Jarett Berry is a Professor of Medicine in the Division of Cardiology at UT Southwestern Medical Center.
Over the last 13+ years, he has led a successful program of research that has been supported through sustained
funding from the NIH and/or the American Heart Assocation. He has established a successful research program
characterizing the impact of exercise on the risk for heart failure with preserved ejection fraction. He has held
leadership roles at UT Southwestern and nationally. Furthermore, he has mentored numerous trainees at all
levels, facilitating their transition to indepdnence as evidenced by their own independent research careers.
Beginning in 2019, he was named the new PI of the Dallas Heart Study, where he is leading a multidisciplinary
effort to characterize the biology of healthy aging in a large, multiethnic cohort. He also developed and serves
as the director of the DHS Exercise Testing Laboratory where his lab performs comprehensive exercise testing
on DHS participants. His current research is funded by a large institional commitment that supports the 3rd
examination of the DHS. His research is also supported by additional funding from the NIH. Therefore he is
well positioned to lead an expansion of his mentoring program that will be supported by this K24 mechanism and
support his long-term career goals: (1) Lead a major research program focused on the prevention of heart failure
with preserved ejection fraction (HFpEF); (2) Improve the understanding of the mechanisms contributing to low
exercise capacity in middle age and identify targeted strategies for treatment; and (3) Develop a new generation
of clinical investigators equipped with knowledge and skill set to conduct high-quality, patient oriented
cardiovascular research. During this award period, the PI will acquire additional leadership training and gain
exposure to advanced imaging techniques using high-field, 7T MRI through attending focused training
experiences and hands-on work with his advanced imaging colleagues. Based on prior research established by
the PI, the central hypothesis of this application is that exercise intolerance in older HFpEF patients reflects the
natural history of low exercise capacity in midlife. The Specific Aims of the proposal are the following: Specific
Aim #1: Characterize peripheral mechanisms of reduced exercise capacity in otherwise healthy middle-aged
and older adults at increased risk for HFpEF. DHS participants will complete (1) functional measurements [VO2
kinetics and oxygen extraction (AVO2 difference) at submax exercise]; and (2) structural measurements (skeletal
muscle volume, muscle fat infiltration). A subset DHS participants will also undergo additional functional in vivo
measurements of mitochondrial function using our established 7T MRI/MRS platform. Specific Aim #2: Compare
the peripheral mechanisms of EI in patients with established HFpEF with otherwise healthy adults with
similar/matched peak V02 using the same measurements as in Aim 1. Trainees will gain experience in patient-
oriented research and participate in informal and formal research training experiences led by the PI as part of
his institutional role in mentoring trainees in the CTSA.
Terms: <21+ years old><ATP Synthesis><ATP Synthesis Pathway><Accounting><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Age><American><Anaerobic Threshold><Award><Berry><Biology><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Clinical><Clinical Investigator><Collaborations><Data><Data Bases><Databases><Diagnosis><EFRAC><Ejection Fraction><Enrollment><Environment><Exercise><Exercise Test><Exposure to><Faculty><Fats><Fatty acid glycerol esters><Funding><Generations><Goals><Heart><Heart Vascular><Heart failure><Hospital Admission><Hospitalization><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Individual><Infiltration><Infrastructure><Institution><Intake><Investigators><K24 Mechanism><K24 Program><Kinetics><Knowledge><Laboratories><Lead><Leadership><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical center><Medicine><Mentors><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><Mitochondria><Muscle><Muscle Tissue><NIH><NMR Imaging><NMR Tomography><Names><National Institute of Aging><National Institute on Aging><National Institutes of Health><Natural History><Nuclear Magnetic Resonance Imaging><O element><O2 element><Oxygen><Participant><Patients><Pb element><Peripheral><Phenotype><Phosphates><Physical activity><Physiology><Position><Positioning Attribute><Prevention><Process><Protocol><Protocols documentation><Recurrence><Recurrent><Reporting><Research><Research Personnel><Research Priority><Research Training><Researchers><Rest><Risk><Role><Skeletal Muscle><Testing><Training><United States National Institutes of Health><Voluntary Muscle><Work><Zeugmatography><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age related alterations><age related changes><age specific alterations><age specific changes><ages><alterations with age><cardiac failure><career><changes with age><circulatory system><cohort><daily living function><daily living functionality><data base><death risk><dietary><effective therapy><effective treatment><enroll><exercise capacity><exercise intolerance><experience><functional ability><functional capacity><healthy aging><healthy human aging><heart failure and reduced ejection fraction><heart failure with reduced ejection fraction><heavy metal Pb><heavy metal lead><high risk><imaging><improved><in vivo><inorganic phosphate><member><mid life><mid-life><middle age><middle aged><midlife><mitochondrial><mitochondrial dysfunction><mortality risk><multi-ethnic><multidisciplinary><multiethnic><muscular><name><named><naming><older adult><older adulthood><patient centered><patient oriented><patient oriented research><patient oriented study><preservation><professor><programs><sarcopenia><sarcopenic><skills><social role><support network><treatment strategy>