Document text
Principal Investigator: Gary R Whittaker
Organization: CORNELL UNIVERSITY
Fiscal Year: 2024
Award: $477,146
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary / Abstract
We propose to develop a novel therapeutic for respiratory viruses, including all current and predicted SARS-
CoV-2 variants, other coronaviruses, influenza, and paramyxo/pneumoviruses—using a peptidomimetic small
molecule approach targeting TMPRSS2 and other trypsin-like proteases (TTSP) that are essential for virus entry.
We expect our therapeutic platform to be applicable and effective for prophylactic use, and so we will target virus
transmission studies in vivo. As our system is based on simple-to-synthesize peptides, which act outside of the
cell, is it expected to be cost–effective, and our approach is specifically designed to cover a range of distinct
viruses. However, it is important to note that our platform is highly flexible, and be applicable in the face of a
novel viruses that may emerge, without significance anti-viral resistance (as it is host-targeted).
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV variant><2019-nCoV variant forms><2019-nCoV variant strains><Airway infections><Animal Model><Animal Models and Related Studies><Anti-viral resistance><Antiproteases><Assay><Bioassay><Biochemical><Biological><Biological Assay><COVID-19 infection><COVID-19 therapeutics><COVID-19 variant><COVID-19 variant forms><COVID-19 variant strains><COVID-19 virus><COVID-19 virus infection><COVID19 infection><COVID19 virus><Cell Body><Cell Culture System><Cell Culture Techniques><Cell membrane><Cells><Cellular biology><CoV emergence><CoV-2><CoV2><Coronaviridae><Coronaviridae Infections><Coronavirus><Coronavirus Infections><Cytoplasmic Membrane><Data><Disease><Disorder><Docking><Drug Targeting><Drug usage><Effectiveness><Endopeptidase Inhibitors><Epitheliasin Gene><Esteroproteases><Ferrets><Goals><Golden Hamsters><Golden Syrian Hamsters><Grippe><H1N1><H1N1 Virus><H2N2><H2N2 Virus><H3N2><H3N2 Virus><H7N9><HCoV><HPIV1><Hemadsorption Type 2 Virus><Hemadsorption Virus 2><Human><Human Metapneumovirus><Human Parainfluenza Virus 1><Infection><Infectious Agent><Influenza><Influenza A Virus, H1N1 Subtype><Influenza A Virus, H2N2 Subtype><Influenza A Virus, H3N2 Subtype><Influenza A Virus, H7N9 Subtype><Influenza HA><Influenza Hemagglutinin><Influenza Virus><Laboratories><Lead><Libraries><MERS corona virus><MERS coronavirus><MERS virus><MERS-CoV><Mediating><Membrane><Mesocricetus auratus><Mice><Mice Mammals><Middle East Respiratory Syndrome Corona Virus><Middle East Respiratory Syndrome Coronavirus><Middle East Respiratory Syndrome Virus><Middle East Respiratory Syndrome-CoV><Middle East Respiratory Virus><Middle East Respiratory coronavirus><Middle Eastern Respiratory Syndrome Corona virus><Middle Eastern Respiratory Syndrome Coronavirus><Middle Eastern Respiratory Syndrome Virus><Middle Eastern Respiratory Syndrome-CoV><Modeling><Modern Man><Murine><Mus><Nature><PRSS10><Para-Influenza Virus Type 1><Paramyxoviridae><Paramyxovirus><Pb element><Peptidase Inhibitors><Peptidases><Peptide Hydrolase Inhibitors><Peptide Hydrolases><Peptide Peptidohydrolase Inhibitors><Peptide Synthesis><Peptides><Plasma Membrane><Pneumoviridae><Pneumovirinae><Pneumovirus><Process><Production><Protease Antagonists><Protease Gene><Protease Inhibitor><Proteases><Proteinase Inhibitors><Proteinases><Proteins><Proteolytic Enzymes><Public Health><Respiratory Epithelium><Respiratory Infections><Respiratory Tract Infections><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 infection><SARS-CoV-2 therapeutics><SARS-CoV-2 variant><SARS-CoV-2 variant forms><SARS-CoV-2 variant strains><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 therapeutics><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Seasons><Serine Endopeptidases><Serine Protease><Serine Protein Hydrolases><Serine Proteinases><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 therapeutics><Severe acute respiratory syndrome related corona virus 2><Site><Specificity><Structure of respiratory epithelium><Syrian Hamsters><System><TMPRSS2><TMPRSS2 gene><Testing><Therapeutic><Transmission><Tripcellim><Trypsin><Viral><Virus><Virus Replication><Work><Wuhan coronavirus><airway epithelium><anti-viral resistant><biologic><cell biology><cell culture><cell cultures><corona virus><corona virus emergence><coronavirus disease 2019 infection><coronavirus disease 2019 therapeutics><coronavirus disease 2019 variant><coronavirus disease 2019 variant forms><coronavirus disease 2019 variant strains><coronavirus disease 2019 virus><coronavirus disease-19 virus><coronavirus emergence><cost effective><design><designing><drug development><drug use><emergent CoV><emergent corona virus><emergent coronavirus><emergent virus><emerging CoV><emerging corona virus><emerging coronavirus><emerging virus><flexibility><flexible><flu HA><flu hemagglutinin><flu infection><flu virus infection><hCoV19><heavy metal Pb><heavy metal lead><human CoV><human corona virus><human coronavirus><improved><in vivo><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><infected with severe acute respiratory syndrome coronavirus 2><infectious organism><influenza infection><influenza viral HA><influenza viral hemagglutinin><influenza virus HA><influenza virus hemagglutinin><influenza virus infection><influenzavirus><inhibitor><innovate><innovation><innovative><interest><lead candidate><membrane structure><model of animal><mouse model><murine model><nCoV><nCoV2><new CoV><new corona virus><new coronavirus><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel CoV><novel corona virus><novel coronavirus><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><novel virus><parainfluenza virus type 1><peptide mimetic><peptide mimic><peptidomimetics><plasmalemma><prevent><preventing><prophylactic><respiratory><respiratory tract epithelium><respiratory virus><response><seasonal coronavirus><seasonal human coronavirus><severe acute respiratory syndrome coronavirus 2 variant><severe acute respiratory syndrome coronavirus 2 variant forms><severe acute respiratory syndrome coronavirus 2 variant strains><small molecule><social role><therapeutic target><therapeutics against COVID-19><therapeutics against SARS-CoV-2><therapeutics against SARS-coronavirus-2><therapeutics against Severe acute respiratory syndrome coronavirus 2><therapeutics against coronavirus disease 2019><therapeutics for novel coronavirus><transmission process><viral emergence><viral multiplication><viral replication><viral transmission><virology><virus multiplication><virus transmission>