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Principal Investigator: CAMILA VENTURA
Organization: RESEARCH TRIANGLE INSTITUTE
Fiscal Year: 2024
Award: $612,740
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
PROJECT SUMMARY/ABSTRACT
Although rates of congenital Zika virus syndrome (CZS) have declined since the 2015–2016 Zika virus
(ZIKV) outbreak in Brazil, transmission of the virus still occurs, with nearly 9,000 cases reported already in
2023. Without global eradication, the threat of another large outbreak exists. Longitudinal research is
necessary to better understand the long-term impact of CZS and factors associated with various health
outcomes. For this application, we will extend our successful collaboration between RTI International and
Altino Ventura Foundation (FAV), to include the University of North Carolina and Purdue University to bring
new, expanded expertise in imaging, EEG, and heart rate sustained attention. We will continue to evaluate
the impact of severe CZS on the medical and developmental outcomes for 187 children who have been
followed since birth. Our cohort, now entering middle childhood, is the largest sample of children with well-
documented CZS to be followed longitudinally since infancy. We will examine the evolution of the primary
clinical signs of CZS (brain, ocular, orthopedic) and assess the long-term medical, developmental, and
mental health outcomes for children with CZS and their families using innovative approaches, such as a
novel heart-rate variability paradigm, that address specific challenges in accurately assessing the
development of children with severe disabilities. Lastly, we will examine malleable predictors of outcomes for
children and their families. This study has the potential to contribute to global knowledge that could lead to
improved outcomes for children and families living with CZS and for children impacted by other conditions
with similar clinical findings.
Terms: <0-11 years old><6-11 years old><Address><Affect><Birth><Brain><Brain Nervous System><Brain imaging><Brazil><Buffers><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cardiac Chronotropism><Case Study><Child><Child Development><Child Support><Child Youth><Childhood><Children (0-21)><Clinical><Clinical assessments><Collaborations><Communities><Data><Development><Diagnosis><Disease Outbreaks><EEG><Electroencephalogram><Electroencephalography><Encephalon><Endocrine><Enrollment><Environment><Environmental Factor><Environmental Risk Factor><Evolution><Family><Foundations><Funding><Future><Generalized Growth><Growth><Health><Heart Rate><Hypophysis><Hypophysis Cerebri><Image><Incidence><Individual><Infant and Child Development><International><Investigators><Knowledge><Lesion><Longitudinal Studies><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Mediation><Mediator><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Health><Mental Hygiene><Metabolic><Modeling><Monitor><NICHD><NMR Imaging><NMR Tomography><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><Natural History><Negotiating><Negotiation><North Carolina><Nuclear Magnetic Resonance Imaging><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Outbreaks><Outcome><Parturition><Pattern><Pelvic><Pelvic Region><Pelvis><Personal Satisfaction><Pituitary><Pituitary Gland><Pituitary Nervous System><Position><Positioning Attribute><Prognosis><Protocol><Protocols documentation><Psychological Health><Publications><Reporting><Research><Research Personnel><Researchers><Retina><Risk Factors><Roentgen Rays><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Schools><Scientific Publication><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severities><Spinal Column><Spine><Standardization><Subgroup><Syndrome><Therapeutic Uses><Time><Tissue Growth><Transmission><Universities><Update><Vertebral column><Work><X-Radiation><X-Ray Radiation><X-ray><Xray><ZIKV><Zeugmatography><Zika Virus><backbone><behavior outcome><behavioral outcome><bone imaging><bone scanning><brain visualization><case report><cohort><community based participatory approach><community based participatory design><community based participatory method><community based participatory process><community participatory approach><community participatory design><community participatory method><community participatory model><congenital zika syndrome><congenital zika virus syndrome><congenital zikv syndrome><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><design><designing><developmental><disability><early adolescence><early childhood><enroll><environmental risk><exposed in utero><fetal exposure><functional outcomes><future outbreak><heart rate variability><imaging><imaging study><improved><improved outcome><in utero exposure><infancy><infantile><innovate><innovation><innovative><intra-uterine environmental exposure><intrauterine environmental exposure><kids><long-term study><longitudinal outcome studies><longterm study><middle childhood><next outbreak><novel><ocular imaging><ontogeny><outbreak in the future><outcome prediction><participant retention><pediatric><prenatal exposure><prenatally exposed><prospective><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skeletal><skeletal imaging><skills><statistics><sustained attention><transmission process><viral transmission><virus transmission><well-being><wellbeing><youngster><zikav>