Document text
Principal Investigator: Steven B Abramson
Organization: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Fiscal Year: 2024
Award: $830,331
Funding agency: National Heart Lung and Blood Institute
ABSTRACT
The goal of this proposal will be to study the frequency, chronicity and etiology of post-acute sequelae of SARS
CoV-2 with protocols designed to characterize genetic and immuno-inflammatory factors that influence post-
COVID complications. We will establish a cohort of 1200 or more deeply phenotyped SARS CoV-2
patients in order to determine the long-term effects of COVID-19 infection in distinct PASC cohorts. Patients
will be categorized by the presence or absence of pulmonary symptoms. We will focus on changes in pulmonary
lung function (DLCO and FVC, TLC) and 6-minute walk test (6MWT) distance at 3, 6, and 12 months and bi-
annually thereafter for 5 years. To assess for progressive pulmonary fibrosis we will include x-rays and
computerized tomography (CT) of the lung. To explore pathogenic mechanisms we will: 1) determine whether
specific cytokine levels associate with the severity or progression of PASC-associated disease; and, 2)
determine whether there is a characteristic autoantibody profile, including anti-cytokine antibodies, in PASC
patients; 3) perform Global Diversity Array (GDA) chip analysis on 1200 patients to develop an unbiased genetic
risk score for PASC; 4) determine whether specific genotypes: a) influence the severity or chronicity of PASC,
including the development of Idiopathic Pulmonary Fibrosis or b) contribute to the sustained immunological
responses in PASC patients. Finally, we will determine whether there is a genetic association with PASC
syndromes that varies across self-identified race/ethnicity (SIRE). Taken together, these novel studies are
intended to better understand pathogenetic mechanisms of disease, which can lead to the identification of
therapeutic targets and strategies for patients with post-acute sequelae.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><AHCPR><AHRQ><Acute><Acute Disease><Affect><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Antibodies><Antibody Response><Autoantibodies><Autoimmune><Autoimmune Mechanism><Autoimmune Process><Automobile Driving><Biological Markers><Black><Black race><Body Tissues><CAT scan><COVID infected patient><COVID patient><COVID positive patient><COVID-19 infected patient><COVID-19 infection><COVID-19 patient><COVID-19 positive patient><COVID-19 sequelae><COVID-19 virus><COVID-19 virus infection><COVID19 infection><COVID19 patient><COVID19 positive patient><COVID19 virus><CT Lung Screening><CT X Ray><CT Xray><CT imaging><CT scan><Carbon Monoxide><Categories><Causality><Characteristics><Chronic><Clinical><Clinical Data><CoV-2><CoV2><Computed Tomography><Data><Development><Diffusion><Disease><Disorder><Dysfunction><Ethnic Origin><Ethnicity><Etiology><Fatigue><Feces><Fibrosing Alveolitis><Forced Vital Capacity><Frequencies><Functional disorder><Future><Genetic><Genetic Diversity><Genetic Polymorphism><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Processes><Genetic Risk><Genetic Susceptibility><Genetic Variation><Genetic propensity><Genotype><Goals><History><IFN><IL-1><IL1><Immune response><Immunochemical Immunologic><Immunologic><Immunological><Immunological response><Immunologically><Immunologics><Immunomodulation><Impairment><Incidence><Individuals from minority><Individuals of minority><Infection><Infection Control><Inflammatory><Inflammatory Response><Inherited Predisposition><Inherited Susceptibility><Interferons><Interleukin I><Interleukin-1><Lack of Energy><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><Long-Term Effects><Longitudinal Studies><Longterm Effects><Lung><Lung CAT Scan><Lung CT><Lung CT scan><Lung Respiratory System><Lung Tissue Fibrosis><Lung symptom><Lymphocyte-Stimulating Hormone><Macrophage Cell Factor><Measures><Minority Groups><Minority People><Minority Population><Minority individual><Nasopharynx><Neighborhoods><Neurocognitive><Non-Polyadenylated RNA><Outcome><PASC><Pathogenicity><Pathway interactions><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Phenotype><Phone><Physiologic><Physiological><Physiopathology><Play><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Process><Protocol><Protocols documentation><Proxy><Pulmonary Fibrosis><Pulse Oximetry><QOL><Quality of life><Questionnaires><RNA><RNA Gene Products><Race><Races><Recording of previous events><Rhinopharynx><Ribonucleic Acid><Risk-associated variant><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 infected patient><SARS-CoV-2 infection><SARS-CoV-2 patient><SARS-CoV-2 positive patient><SARS-CoV-2 sequelae><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome related corona virus 2><Severities><Shortness of Breath><Social outcome><Socio-economic status><Socioeconomic Status><Symptoms><Syndrome><T Helper Factor><Telephone><Testing><Tissues><Tomodensitometry><Total Lung Capacity><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><Vaccination><Vital capacity><Walking><Wuhan coronavirus><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><acute COVID-19><acute SARS-CoV-2 infection><acute disease/disorder><acute disorder><acute infection><acute phase of COVID-19><acute phase of SARS-CoV-2 infection><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><autoimmune antibody><autoreactive antibody><bio-markers><biologic marker><biomarker><black patient><breakthrough infection><catscan><causation><chronic COVID><chronic COVID-19><chronic COVID-19 sequelae><chronic complication of COVID-19><chronic effect of COVID-19><chronic novel coronavirus disease 2019><chronic symptom><cognitive assessment><cognitive testing><cohort><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><computerized tomography lung screening><coronavirus disease 2019 infected patient><coronavirus disease 2019 infection><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease 2019 virus><coronavirus disease infected patient><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19 patient><coronavirus disease-19 virus><coronavirus patient><cytokine><deprivation><design><designing><developmental><diffuse interstitial pulmonary fibrosis><diffused><diffuses><diffusing><diffusions><disease causation><disparity in health><driving><fibrosis in the lung><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following infection by SARS-CoV-2><following severe acute respiratory distress syndrome CoV-2 infection><genetic association><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><hCoV19><health disparity><histories><host response><idiopathic pulmonary fibrosis><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><indexing><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><long haul COVID><long haul COVID-19><long haul coronavirus disease><long haul coronavirus disease 2019><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long term consequences of COVID-19><long term consequences of SARS-CoV-2 infection><long term consequences of coronavirus disease-19><long term effects of COVID-19><long term health consequences of COVID-19><long term health consequences of SARS-CoV2 infection><long term impact of COVID-19><long term impact of SARS-CoV-2 infection><long-hauler COVID><long-hauler COVID-19><long-hauler coronavirus disease 2019><long-hauler syndrome><long-term COVID><long-term COVID-19><long-term consequence of severe acute respiratory distress syndrome-cov-2 infection><long-term coronavirus disease><long-term coronavirus disease 2019><long-term effects of coronavirus disease-19><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><long-term study><longitudinal outcome studies><longterm COVID><longterm COVID-19><longterm consequences of COVID-19><longterm consequences of SARS-CoV-2 infection><longterm coronavirus disease><longterm coronavirus disease 2019><longterm effects of COVID-19><longterm health consequences of COVID-19><longterm health consequences of SARS-CoV2 infection><longterm impact of COVID-19><longterm impact of SARS-CoV-2 infection><longterm study><lung computerized axial tomography scan><lung computerized tomography><lung computerized tomography scan><lung fibrosis><lung function><lymphocyte activating factor><nCoV2><nasopharnygeal><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><pathophysiology><pathway><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient stratification><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><persistent COVID-19><persistent symptom><polymorphism><post COVID syndrome><post COVID-19 complications><post COVID-19 related complications><post COVID-19 sequelae><post COVID-19 syndrome><post SARS-CoV-2 infection><post acute COVID syndrome><post acute COVID-19><post acute COVID-19 syndrome><post acute SARS-CoV-2><post acute coronavirus disease 2019><post acute coronavirus disease 2019 syndrome><post acute coronavirus disease syndrome><post acute sequelae following COVID-19><post acute severe acute respiratory syndrome coronavirus 2><post coronavirus disease 2019 syndrome><post coronavirus disease syndrome><post-COVID><post-COVID-19><post-acute phases of COVID-19><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><post-coronavirus disease 2019><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><primary end point><primary endpoint><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><prolonged COVID-19 symptoms><pulmonary><pulmonary function><pulmonary symptom><racial><racial background><racial origin><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><secondary outcome><self reactive antibody><sequelae following COVID-19><sequelae following SARS-CoV-2 infection><sequelae of COVID-19><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><social determinants><social health determinants><social role><socio-economic position><sociodeterminant><socioeconomic position><stool><stratified patient><therapeutic target>