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Principal Investigator: Robert J Carroll
Organization: BROAD INSTITUTE, INC.
Fiscal Year: 2020
Award: $217,232
Funding agency: National Human Genome Research Institute
PROJECT SUMMARY
In response to the COVID-19 pandemic, the Host Genetics Initiative (HGI) has formed to generate, share, and
analyze data to identify the underlying genetic determinants of the SARS-CoV-2 infection and disease,
including the severity in symptomatic presentation and associated outcomes, as well as the development of
hypotheses for drug repurposing. To achieve the aims of the consortium, the need for a mechanism to ingest
data and make it broadly available for researchers arose. With the National Human Genome Research
Institute’s commitment to the same goals, the AnVIL, which is predicated on providing a cloud environment for
the analysis of large genomic and clinical datasets, became the eminent choice to serve as a data repository
and analysis platform for the consortium. As the technology has been developed through the parent grant, the
aims proposed for this grant allows the AnVIL to provide scalable support for the Host Genetics Initiative in
their utilization of the AnVIL. The specific aims include:
• Aim 1: Scale the data Ingest processes for genotypic, phenotypic, clinical report data and metadata to
support the expected influx of data from the Host Genetics Initiative
• Aim 2: Utilize the Data Use Oversight System (DUOS) to facilitate expeditious data governance and
access requests
• Aim 3: Dissemination of data for researchers via featured workspaces done in partnership with the
Host Genetics Initiative
• Aim 4: Provide support for new data generator and user communities
Through the implementation of these aims over the course of one year, we will enable the data that is
generated by the members of the Host Genetics Initiative to be broadly shared and analyzed with researchers
inside and outside of the consortium, which will serve to contribute to the global knowledge of the biology of
SARS-CoV-2 infection and disease.
Terms: <2019 novel coronavirus><2019-nCoV><Award><Biology><COVID-19><COVID-19 epidemic><COVID-19 pandemic><COVID19><COVID19 epidemic><COVID19 pandemic><Certification><Clinical><Communities><Consent><Data><Data Analyses><Data Analysis><Data Banks><Data Reporting><Data Set><Databanks><Dataset><Development><Disease><Disorder><Drugs><Ensure><Environment><Ethics><Fostering><Funding><Generalized Growth><Generations><Genetic><Genetic Determinism><Genetic Research><Genome><Genomics><Genotype><Goals><Grant><Growth><Guidelines><Human Genetics><Individual><Infection><Ingestion><Intake><Investigators><Knowledge><Lead><Learning><Libraries><Medication><Metadata><Methods><Mission><NHGRI><National Center for Human Genome Research><National Human Genome Research Institute><Outcome><Parents><Patients><Pb element><Pharmaceutic Preparations><Pharmaceutical Preparations><Phenotype><Predisposition><Preparation><Procedures><Process><Protocol><Protocols documentation><Questionnaires><Reaction Time><Research><Research Design><Research Personnel><Researchers><Resource Sharing><Response RT><Response Time><Risk><Role><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Sampling><Severe acute respiratory syndrome coronavirus 2><Severities><Study Type><Susceptibility><System><Technology><Time><Tissue Growth><United States><Work><Wuhan coronavirus><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 epidemic><coronavirus disease 2019 pandemic><data access><data depository><data dissemination><data ecosystem><data ingestion><data interpretation><data repository><data representation><data sharing><data sharing ecosystem><data standardization><data standards><data warehouse><developmental><drug/agent><ethical><experience><genetic determinant><heavy metal Pb><heavy metal lead><improved><member><meta data><ontogeny><parent grant><psychomotor reaction time><response><social role><study design>