Novel Nanoparticle-in-Hydrogel Co-delivery of Adjuvanted saRNA as HIV Vaccine

NIH Pandemic-Era Grants

Pandemic Era Grants

2020

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Principal Investigator: FANG  LIU
Organization: ZYMERON CORPORATION
Fiscal Year: 2020
Award: $300,000
Funding agency: National Institute of Allergy and Infectious Diseases

Particle-Based Co-Delivery of HIV Immunogens as Next-Generation HIV Vaccines: A major focus of HIV vaccine research has been the development of immunogens that elicit broadly neutralizing antibody responses targeting the envelope protein (Env). While the field has predominantly focused on immunogen design and soluble antigens, the targeted and controlled delivery of antigens has not received much attention and is a gap in the HIV field that needs to be addressed. Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, selfamplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies.

Terms: <AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adjuvant><Affinity><Antibody Response><Antigen Targeting><Antigen-Presenting Cells><Antigens><Attention><Development><Encapsulated><Envelope Protein><GM-CSF><Granulocyte-Macrophage Colony-Stimulating Factor><HIV><HIV vaccine><HIV/AIDS Vaccines><Histamine-Producing Cell-Stimulating Factor><Human Immunodeficiency Viruses><Hydrogels><Injectable><LAV-HTLV-III><Lymphadenopathy-Associated Virus><Messenger RNA><Molgramostin><Non-Polyadenylated RNA><Nucleic Acids><Polyrotaxanes><RNA><RNA Gene Products><Ribonucleic Acid><Sarna><System><TC-GM-CSF><Tumor-Cell Human GM Colony-Stimulating Factor><Vaccine Research><Virus-HIV><accessory cell><base><cytokine><design><designing><developmental><env Antigens><env Gene Products><env Polyproteins><env Protein><granulocyte macrophage colony stimulating factor><human immunodeficiency virus vaccine><immunogen><mRNA><monomer><nano><nano particle><nano particle delivery><nano-sized particle><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><neutralizing antibody><next generation><novel><particle><site targeted delivery><targeted delivery>