Infection and Rapid Transmission of SARS-C0V-2 in Ferrets

NIH Pandemic-Era Grants

Pandemic Era Grants

2021

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Principal Investigator: Jae U Jung
Organization: CLEVELAND CLINIC LERNER COM-CWRU
Fiscal Year: 2021
Award: $519,707
Funding agency: National Institute of Allergy and Infectious Diseases

Project Summary/Abstract
 The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been
rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In
order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), understanding the in vivo characteristics of viral infection and transmission is of high priority.
Specifically, an animal model that recapitulates the COVID-19 clinical symptoms in human infection
is urgently needed in order to decipher the transmission routes and pathobiology of this virus and
ultimately allow testing of pharmaceutical interventions. With our expertise in the development of
animal model, we have recently established a ferret model for SARS-CoV-2 infection and
transmission that highly recapitulates aspects of the human infection. The main goal of this study is
to comprehensively characterize ferret animal model for SARS-CoV-2 infection, transmission and
pathogenesis for vaccine interventions.

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