Long-term reliable neuroprosthetic control of a robotic arm and hand using electrocorticography.
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Principal Investigator: Edward Chang Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Fiscal Year: 2024 Award: $655,924 Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development PROJECT SUMMARY Multiple neurological diseases [e.g. spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), brain stem stroke] can all result in severe and devastating limb paralysis. A recent comprehensive assessment found that >200,000 patients suffer from tetraplegia or severe tetraparesis that prevents completion of basic activities of daily living that require arm and hand functions. Surveys of such patients have indicated that improvement of arm and hand function is a top priority. There are no current therapies or assistive devices that can aid patients with tetraplegia or severe tetraparesis to experience restoration of reaching and grasping functionality. Our proposal aims to test methods to enable such patients to directly control a complex robotic arm and hand with the capacity to perform a set of clinically relevant tasks. Our specific goals are to leverage the stability of ECoG to establish robust robotic control that is stable across a period of at least 8 weeks without need for recalibration. Our published data along with new preliminary data supports the notion that ECoG signals can allow a paralyzed individual to learn complex neuroprosthetic control that requires no additional training. We will compare two decoding methods and their ability to enable long-term stable ‘plug-and-play’ complex control. We then aim to further boost robustness of real-world control in two ways. First, we will track fluctuations in neural states to reduce decoding errors; this is key for long-term continuous accurate control. Second, we will test a system that can assist with pre-shaping the robot during neuroprosthetic control. Together, our aims will determine the feasibility of complex control of neuroprosthetic technology in a target population of paralyzed patients with severe disability. We will determine how well ECoG can enable stable and intuitive control of a robotic arm and hand that can enable reaching, grasping and flexible manipulation of objects. We strongly believe that demonstration of these outcomes will drive the field towards clinically viable neuroprosthetic control and thereby dramatically improve the quality of life for paralyzed patients. Terms: <Accounting><Activities of Daily Living><Activities of everyday life><Algorithms><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Apoplexy><Assistive Technology><Attention><Brain Stem><Brain Vascular Accident><Brainstem><Calibration><Cell Communication and Signaling><Cell Signaling><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Complex><Crowding><Cues><Data><Devices><Drops><Electrocorticogram><Environment><Exhibits><Extremities><Eye><Eyeball><Fatigue><Freedom><Frequencies><Gehrig's Disease><Goals><Grips><Hand><Hand functions><Home><Home environment><Individual><Intracellular Communication and Signaling><Intuition><Joints><Lack of Energy><Language><Learning><Liberty><Limb structure><Limbs><Lou Gehrig Disease><Mechanics><Methods><Modeling><Motor disability><Movement><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Trunk><Outcome><Outcome Measure><Palsy><Paralysed><Patients><Performance><Play><Plegia><Process><Publishing><QOL><Quadriplegia><Quadriplegic><Quality of life><Research><Robot><Robotics><Self-Help Devices><Seminal><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Speech><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stroke><Survey Instrument><Surveys><System><Target Populations><Technology><Testing><Tetraplegia><Thumb><Thumb structure><Time><Training><Translations><Traumatic Myelopathy><Update><Using hands><Work><arm><arm function><arm functionality><assisted device><assistive device><assistive robot><assistive robotic><biological signal transduction><body movement><brain attack><brain based><brain computer interface><cerebral vascular accident><cerebrovascular accident><clinical relevance><clinically relevant><cognitive burden><cognitive load><daily living function><daily living functionality><disability><electrocorticography><experience><flexibility><flexible><functional ability><functional capacity><gain of function><gaze><grasp><hands><homes><improved><intuitive><kinematic model><kinematics><measurable outcome><mechanic><mechanical><multi-task><multitask><neural><neural control><neural correlate><neural regulation><neuro-prosthetic><neurological disease><neuromodulation><neuromodulatory><neuroprosthesis><neuroprosthetic><neuroregulation><outcome measurement><paralysis><paralytic><prevent><preventing><restoration><robot control><robotic control><robotic device><skills><stroked><strokes><tetraplegic><translation><visual search>