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Principal Investigator: William A Petri
Organization: UNIVERSITY OF VIRGINIA
Fiscal Year: 2024
Award: $598,766
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
PROJECT SUMMARY
Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately
from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, and maternal
mortality from childbirth, vaccine failure and impaired child development. The UVA-icddrb Research Unit (RU)
addresses critical needs of women and young children by bringing to the Network strengths in infectious
diseases, lactation, pharmacology, neurocognitive development, human genetics, maternal-fetal medicine,
immunology, vaccinology and CTSA coordination. The RU has access to nearly 8000 pregnant women
annually at our existing clinical trial sites, is highly attuned to ethical and cultural issues with local community
and ethical review boards, and leads Network studies of COVID-19 in pregnancy and maternal anemia.
Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul
Haque have for 30 years co-led multidisciplinary teams studying maternal-child health, with over 170 co-
publications and ten on-going or completed clinical studies in the last five years. They are joined at icddr,b and
UVA by a diverse and multidisciplinary core team of 19 accomplished investigators in maternal-child health.
Innovation: The RU conceptualized the multi-site study of COVID-19 infection during pregnancy that
demonstrated minimal impact on birth outcomes, is leading a study of the role of maternal anemia on low-birth
weight infants, has multi-site Network-approved protocols on maternal nutritional supplements and on
asymptomatic bacteriuria and has pioneered electronic data capture for the Network. Special capabilities
include infectious diseases, pharmacology, lactation, and novel clinical trial designs through the CTSA.
Approach: The RU has conducted 12 clinical trials since 2016 with 99% adherence to follow-up visits, and
access to 8000 pregnant women annually in existing clinical trial sites. Science to policy translation catalyzed
by the partnership of the icddr,b with the Government of Bangladesh, as evidenced by the worldwide
implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide, and the Matlab
model of community -based care.
Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban
and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in
the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases
and International Health has a unique focus on Global Health, with over $16 million in annual grant support and
over two dozen active clinical protocols. UVa-icddrb unique and complementary expertise will continue to bring
unparalleled strengths to the Network’s goal of making sustainable improvements in maternal and child health.
Terms: <0-11 years old><Active Follow-up><Address><Adherence><Adoption><Airway infections><Anemia><Azadose><Azithromycin><Azitrocin><Azythromycin><Bacteriuria><Bangladesh><Birth><Budgets><COVID-19><COVID-19 infection><COVID-19 virus infection><COVID19 infection><CV-19><Cell Phone><Cellular Phone><Cellular Telephone><Child><Child Development><Child Health><Child Youth><Childbirth><Childhood><Children (0-21)><Clinical Protocols><Clinical Research><Clinical Research Protocols><Clinical Study><Clinical Trials><Clinical Trials Design><Clinical Trials Network><Communicable Diseases><Communities><Conduct Clinical Trials><Coronavirus Infectious Disease 2019><Country><Development><Diarrhea><Dietary Deficiency of Infants><Economic Income><Economical Income><Educational Mainstreaming><Enrollment><Environment><Equipment><Equity><Ethical Review><Ethics><Fecundability><Fecundity><Fertility><Financial Management><Gender><Gestation><Goals><Government><Grant><Health><Health Facilities><Health care facility><Healthcare Facility><History><Hospitals><Human Genetics><Human Resources><Human Rights><Immunology><Impairment><Income><Infant><Infant Malnutrition><Infant Nutritional Deficiency><Infant Undernutrition><Infant and Child Development><Infantile Malnutrition><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Inservice Training><International><Investigators><Kinetics><Laboratories><Lactation><Leadership><Low Birth Weight Infant><Mainstreaming><Manpower><Maternal Mortality><Maternal and Child Health><Maternal-fetal medicine><Mobile Phones><Modeling><Mothers><NICHD><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><Neonatal Mortality><Neonatology><Neural Development><Neurocognitive><Occupational activity of managing finances><On-the-Job Training><Oral><Outcome><Outcome Study><Paper><Parturition><Pharmacodynamics><Pharmacology><Policies><Population><Pregnancy><Pregnant Women><Principal Investigator><Protocol><Protocols documentation><Publications><Publishing><Recording of previous events><Registries><Rehydration Solutions><Reproductive Health><Research><Research Personnel><Researchers><Reservations><Respiratory Infections><Respiratory Tract Infections><Role><Rural><Rural Population><Rural group><Rural people><SARS-CoV-2 infection><SARS-CoV2 infection><Science><Scientific Publication><Scientist><Sepsis><Services><Severe acute respiratory syndrome coronavirus 2 infection><Site><Structure><Training><Translations><Ultreon><Underrepresented Ethnic Minority><Underrepresented Minority><Universities><Urban Population><Virginia><Visit><Woman><Zithromax><Zitromax><achievement Mainstream Education><active followup><blood infection><bloodstream infection><care facilities><child birth><clinical research site><clinical site><community based care><coronavirus disease 2019><coronavirus disease 2019 infection><coronavirus disease-19><coronavirus infectious disease-19><data centers><data communication><death among neonates><death among newborns><death in neonates><death in newborn><design><designing><developmental><diet supplement><dietary supplements><diversity, equity, and inclusiveness><electronic data><enroll><equity, diversity, and inclusion><ethical><expectant mother><expecting mother><experience><follow up><follow-up><followed up><followup><gender-based violence><global health><health of the mother><histories><iPhone><implementation science><improved><incomes><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><innovate><innovation><innovative><invention><kids><laboratory facility><lactating><lactational><low birth weight><low birthweight><maternal death><mortality among neonates><mortality among newborns><mortality in neonates><mortality in newborns><multidisciplinary><neonatal death><neonatal demise><neonatal health><neurodevelopment><newborn death><newborn health><newborn mortality><novel><nutrition><nutritional supplement><pediatric><pediatric pharmacology><personnel><pregnant mothers><prevent><preventing><recruit><rural individual><smart phone><smartphone><social role><translation><under-representation of minorities><under-represented minority><underrepresentation of minorities><urban group><urban individual><urban people><vaccine failure><vaccinology><youngster>