Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
DUXIN SUN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2023 · $513,210 — Various nanoparticles (NPs) have been used for delivery of small antigens, which have limited viral mimic features and are more efficacious than soluble antigens in stimulating B-cell immunity. However, these traditional NPs lack characteristics of virus “spiky capsid protein peplomer”, e.g. spiky a…
Jose Maria Martinez-Navio · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 · $785,297 — Project Summary/Abstract The poor immunogenicity of the HIV envelope spike and its vast variability represent major obstacles for efficient elicitation of protective anti-HIV antibodies. One promising strategy is to bypass the immune system and deliver already known and well-characterized potent and…
MARK ROBERTS LOONEY · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $623,280 — Project Summary/Abstract The acute respiratory distress syndrome (ARDS) was first formally described in 1967, but it has likely been the predominant cause of death in pandemic viral infections for centuries. Now, the world is at grips with a new pandemic from SARS-CoV-2, or COVID-19, which has infec…
Nicola Decaro · OHIO STATE UNIVERSITY · 2023 · $205,587 — 1 Project Summary 2 There is growing evidence that canine coronaviruses (CCoVs) can infect humans and be associated with 3 clinical (mostly acute respiratory) illness in children and adults. Human infections with CCoVs with recombinant 4 canine-feline-porcine spike proteins (hCFPL-CoVs) have been…
Gillian Fitz · VANDERBILT UNIVERSITY · 2023 · $30,666 — PROJECT SUMMARY/ABSTRACT In Eukarya, actin-based protrusions such as filopodia, stereocilia, and microvilli, support a wide variety of cellular functions including motility, mechanosensation, and nutrient absorption. Formation of a surface protrusion involves deformation of the plasma membrane, and…
WALTHER H MOTHES · YALE UNIVERSITY · 2023 · $825,206 — Summary The COVID19 pandemic may take 1-3 years and only fully subside once we reach herd immunity. Given the high mortality of COVID19, it is of critical importance to reach herd immunity through a vaccine. The viral spike glycoprotein (S) is central to our efforts for developing an effective vacci…
Nir Hacohen · BROAD INSTITUTE, INC. · 2023 · $221,595 — The development of scalable, cost-effective antibody libraries for detecting proteins (or other molecules) has greatly lagged the development of methods for detecting (e.g. by hybridization or sequencing) specific RNA or DNA sequences. If we were able to engineer antibodies against diverse targets a…
FREDERICK R BLATTNER · DNASTAR, INC. · 2023 · $1,000,000 — Therapeutic monoclonal antibodies bind to specific regions of proteins called epitopes, which elicit cellular responses that treat or cure disease. Discovering therapeutic antibodies traditionally requires costly and labor- intensive, laboratory-based screening experiments. Computational approaches …
Priyamvada Acharya · DUKE UNIVERSITY · 2023 · $683,445 — Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1 A glycan shield covers the HIV-1 envelope (Env) limiting antibody access to broadly neutralizing antibody (bnAb) epitopes. 2G12 had for long been the only example of a HIV-1 bnAb that interacts solely with…
Peter Daszak · ECOHEALTH ALLIANCE, INC. · 2023 · $576,290 — Modified Project Summary/Abstract Section Zoonotic coronaviruses (CoVs) are a significant threat to global health, as demonstrated by the emergence of SARS, MERS, and COVID-19. Our group identified bats as the wildlife reservoirs of SARS-CoV, and we have now published hundreds of novel SARS-related…
Demonta Coleman · TEXAS A&M UNIVERSITY · 2023 · $38,073 — Project Summary The current cancer treatment bottleneck showcases the need for more innovative approaches in drug discovery efforts. As of recent, immune-checkpoint inhibitors (ICHs) have shown promise in cancer therapeutics, and work by manipulating immunoregulatory pathways involved in tumor detec…
Todd A Wyatt · OMAHA VA MEDICAL CENTER · 2023 — My primary research interests address chronic inflammatory lung disease, and the impact that behavioral and environmental exposures play in the compromise of lung innate defense against pathologic lung infections and injury. Utilizing pre-clinical mouse models and state-of-the-art molecular, biochem…
Ann Venables Griffith · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2023 · $193,750 — Summary The novel coronavirus, SARS-CoV-2, and the resulting Coronavirus Infectious Disease 2019 (COVID-19) has caused more than 500,000 deaths in the US. COVID-19 causes increased mortality and morbidity in patients over 65 years of age relative to younger patients. This is consistent with well-cha…
Deyu Fang · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $748,517 — Abstract Biomarker-guided treatment is key to improve outcomes of many diseases. The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis due to lagged vaccination and inefficient control of the virus, which has caused over 253 million c…
STEPHEN COPLAN HARRISON · BOSTON CHILDREN'S HOSPITAL · 2023 · $420,375 — Summary The structure of a virus particle must conform to the mechanism by which it enters and infects a cell. We seek to relate structures of virus particles and viral surface proteins to mechanisms of the steps in cell attachment, uptake and penetration that initiate a productive infection. The pr…
Yehia Mechref · TEXAS TECH UNIVERSITY · 2023 · $302,855 — Glycosylation is one of the most complex protein modifications; more than 50% of mammalian proteins are glycosylated. The fact that there are 100,000 proteoforms coded by only ~20,300 genes identified in the human genome emphasizes the importance of posttranslational modifications (PTMs) like glycos…
Magnus Adrian Gero Hoffmann · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2023 · $421,000 — Project Summary/Abstract The COVID-19 pandemic represents the 3rd outbreak caused by zoonotic transmission of a beta-coronavirus (beta-CoV) in the last 20 years. Hence there is an urgent need for new vaccine strategies to control the ongoing pandemic and prevent future CoV outbreaks. mRNA vaccines h…
Matthew Reed Steinhart · INDIANA UNIVERSITY INDIANAPOLIS · 2023 · $2,500 — ABSTRACT Neurofibromatosis Type 2 (NF2) is a genetic condition in which specific types of tumors form in various locations throughout the body. Though the majority of these tumors grow slowly, the location of certain tumors can cause significant dysfunction. One of these tumor types grows on the ves…
Melody Y Zeng · WEILL MEDICAL COLL OF CORNELL UNIV · 2023 · $678,002 — Abnormal and potentially life-threatening blood clotting is seen in other severe infections, such as SARS- CoV-2, MERS, and H1N1 influenza. Platelets are produced by megakaryocytes. Enhanced megakaryopoiesis is found in severe COVID-19. Increased megakaryopoiesis is commonly found in autoimmune dise…
Joyce Jose · PENNSYLVANIA STATE UNIVERSITY, THE · 2023 · $236,286 — Mosquito-borne alphaviruses such as chikungunya, Mayaro, and Eastern equine encephalitis viruses cause high morbidity and mortality in their mammalian hosts. Alphaviruses are globally distributed arthropod-borne viruses that are enzootic in nature with the potential to disseminate to new geographica…