Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Hsien Wei YEH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2023 · $249,000 — úú PROJECT SUMMARY/ABSTRACT Delivering diagnostic services at the point-of-care (POC) can improve the quality of healthcare in clinics, in emergency settings, or at home, which can potentially ease hospitals’ burden, for instance, during the COVID- 19 pandemic. Precision and personalized medicine re…
Barton F. Haynes · DUKE UNIVERSITY · 2023 · $10,478,045 — Abstract - Overall Compared to SARS-CoV-1 and MERS, the current SARS-CoV-2 virus is highly transmissible and to date has caused over 85,000,000cases worldwidewith over 1,800,000 deaths. With an endemic population of multipleother strains of CoVs in bats, rodents with intermediate hosts, civets and p…
Kiesha Wilson · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2023 · $248,958 — PROJECT SUMMARY/ABSTRACT The virus, SARS-CoV-2 has caused COVID-19 and claimed the lives of over 240,000 Americans and 1,270,000 people worldwide. Severe cases of the disease leads to Acute Respiratory Distress Syndrome (ARDS), sepsis and can be fatal due to pulmonary inflammation and destruction of…
John D Mountz · BIRMINGHAM VA MEDICAL CENTER · 2023 — The COVID-19 caused by the SARS-CoV-2 coronavirus infection is currently a global pandemic. The most important question is why some individuals produce rapid protective antibodies (Abs) and exhibit null or only mild symptoms, whereas others do not? A second urgent question is if a standard laborator…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2023 · $748,081 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
Wayne A. Marasco · DANA-FARBER CANCER INST · 2023 · $874,734 — Project Summary The emergence of the novel human betacoronavirus SARS-CoV2 in Wuhan, China in 2019 has rapidly evolved into a worldwide pandemic. Over a 100 million people have been infected and there have been several million deaths. There is also great disparity in the manner in which COVID-19 ill…
Alex Joseph Guseman · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2023 · $52,084 — Project Summary/Abstract In late 2019, the SARS-CoV2 virus emerged as a global pandemic, causing the severe respiratory disease COVID-19 and resulting in millions of deaths worldwide. As a coronavirus, SARS-CoV2 host interactions are dictated through the Spike proteins that encompass the virion. The…
Chang Liu · JOHNS HOPKINS UNIVERSITY · 2023 · $468,938 — PROJECT SUMMARY/ABSTRACT Over the last two decades, three highly pathogenic human coronaviruses, including SARS-CoV-2, have emerged, arguing that future deadly pandemics of new or re-emerging coronaviruses and other RNA viruses are almost inevitable. The urgent need to treat these fatal infectious …
Rajesh Khanna · NEW YORK UNIVERSITY · 2023 · $95,887 — ABSTRACT Nociceptive pain is a protective response to harmful stimuli that is necessary to survival while nociplastic pain represents altered nociception arising from a sensitization of peripheral nociceptor neurons leading to subthreshold inputs eliciting a pain response. While studying a potential…
Kyuyeon Han · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $199,875 — Project Summary/Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could behave similar to the influenza virus, re- emerging every year in slightly different forms. More importantly, SARS-CoV-2 keeps making various mutants with higher infection rates than previous ones. The spike …
Hong Yan Liu · DOTQUANT, LLC · 2023 · $275,482 — ABSTRACT The COVID-19 pandemic caused by SARS-CoV-2 viruses has had an unprecedented disruptive global impact. Although vaccination has been expected to end the spread, the fast mutations have increased the breakthrough infection rates in the fully vaccinated population. RNA viruses are known to hav…
Samuel Matthew Young · UNIVERSITY OF IOWA · 2023 · $370,077 — The diversity of information encoding by neuronal circuits is regulated by the magnitude and location of Ca2+ entry though voltage-gated Ca2+ channels (CaV). In the mammalian central nervous system, the CaV2.1 channel is the critical subtype for CNS function since it is the most efficient CaV2 subty…
Yi-Chih Lin · UNIVERSITY OF TEXAS AT AUSTIN · 2023 · $389,820 — Abstract: Spike glycoprotein (S-protein) is one of the viral transmembrane proteins on the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). S- protein plays a crucial role in mediating the initial entry of viral genome i…
Michael A Barry · MAYO CLINIC ROCHESTER · 2023 · $470,627 — Abstract Many COVID-19 vaccines are replication-defective mRNA, DNA, or adenovirus (Ad) vaccines. In each case, the vaccine delivers its one copy of an antigen gene and expresses "1X" of the antigens that are encoded by the vaccine. We developed single cycle Ad (SC-Ad) vaccines that replicate vaccin…
Andrew Laurence Routh · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $398,043 — RNA viruses are exceptionally diverse and rapidly evolving. Their RNA-dependent RNA polymerases are prone to mutation, lack proof-reading capabilities (with the unique exception of coronaviruses) and frequently undergo recombination between both homologous and non-homologous templates. This confers …
Rajesh Khanna · UNIVERSITY OF FLORIDA · 2023 · $1,926,350 — ABSTRACT Nociceptive pain is a protective response to harmful stimuli that is necessary to survival while nociplastic pain represents altered nociception arising from a sensitization of peripheral nociceptor neurons leading to subthreshold inputs eliciting a pain response. While studying a potential…
Wei Zheng · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2023 · $2,859,284 — In collaboration with NIH and external academic and industry researchers, we have carried out assay development and performed drug repurposing screens for multiple projects across a range of therapeutic areas, including COVID-19, rare genetic disorders and rare drug resistant cancers. DISEASE MO…
MICHAEL C SNELLER · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $648,551 — COVID-19 was identified in early 2020, and this newly recognized viral disease went on to become a worldwide pandemic. The clinical characteristics and spectrum of disease severity of acute COVID-19 were being defined, with a significant portion of those infected developing severe disease manifestat…
Mark Connors · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $107,663 — Our laboratory is engaged in the study of the immune response to SARS-CoV-2 in two major areas. The first of these is the study of the immune response to natural infection. The second is the response to virus-like particles or replicating recombinant adenovirus type 4 (Ad4) vaccines. We are colla…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2023 · $502,510 — While antibody-based therapeutics have emerged as a major component in cancer treatment, the generation of antibodies to important targets such as cell surface receptors and ion channels remains difficult. These proteins contain buried functional sites that are often unreachable by classical mouse o…