Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Naoko Mizuno · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2023 · $536,871 — We hypothesize that SARS-Cov2 directly interacts with neutrophils as well as platelets through their receptors, and induces a change in platelet morphology, leading to their activation and coagulation. We performed live imaging showing that platelets are directly activated in the presence of purifie…
Thomas Eggerman · CLINICAL CENTER · 2023 — Using human SR-BI (hSR-BI) and human SR-BII (hSR-BII) transgenic mice, we have found that SR-BI and, to a lesser extent, SR-BII protect against bacterial LPS-induced lung damage: At 20 hours after intratracheal LPS instillation, the extent of pulmonary inflammation and vascular leakage was signific…
Lesia Dropulic · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $873,600 — This project includes the evaluation of a vaccine candidate targeting SARS-CoV-2, mRNA-1273, that was administered to healthy volunteers in a phase 1 trial (DMID 20-0003). This project also includes the collection of samples for translational immunology research from participants who have been vacci…
Doreen Matthies · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2023 · $3,623,275 — (1) Structure and function of magnesium channel Mrs2 Mrs2 is the eukaryotic homolog of bacterial magnesium channel CorA. CorA forms a homo-pentameric channel which forms a symmetric closed state at normal to high concentrations of magnesium with magnesium binding sites between protomers as well as n…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2023 · $1,950,208 — The development of a safe and effective vaccine and to improve treatment strategies aiming to reduce/eliminate the virus reservoir are currently at the forefront of our research. Based on our recognition of the fundamental mechanisms of mRNA expression, exemplified by the regulated expression of HIV…
JAY A BERZOFSKY · DIVISION OF BASIC SCIENCES - NCI · 2023 · $2,147,209 — In vivo vaccine studies in macaques and hamsters: Rhesus macaques have been primed IM with S1 spike protein in different adjuvants and boosted systemically with spike in alum or mucosally intranasally with spike in nanoparticles with IL-15 and TLR ligand adjuvants. We have found and published that n…
Nadya Tarasova · DIVISION OF BASIC SCIENCES - NCI · 2023 · $40,169 — The reliability, and consequently success of virtual screening depends heavily on the accuracy of the x-ray structure depiction of the target protein structure in solution. Crystal packing can distort conformation of flexible parts of the protein thus leading to misrepresentation of the protein stru…
Mary N. Carrington · DIVISION OF BASIC SCIENCES - NCI · 2023 · $127,700 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic. The pandemic's impact has spurred research into the pathogenesis, diagnosis, treatment, and prevention of SARS-CoV-2 and its emerging variants of concern. Prior studies have elucidated the …
eric freed · DIVISION OF BASIC SCIENCES - NCI · 2023 · $54,403 — In a structural and functional analysis of the SARS-CoV-2 S protein that we recently started, we have determined that MARCH8, but not a catalytically inactive MARCH8 mutant, targets the S proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2 for degradation. We also showed that human airway epithelial cell…
JAMES L ARTHOS · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $109,700 — Intranasal administration led to rapid lung alveolar macrophage uptake, pulmonary vascular leakage, and neutrophil recruitment and damage. Exposure to the spike protein enhanced neutrophil NETosis and augmented human macrophage TNF- and IL-6 production. Human and murine immune cells employed C-type …
Joshua Hoong Yu Tan · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $568,478 — The overarching goal of this project is to study the immune response to COVID-19 at the monoclonal level to increase our understanding of basic biology and develop new tools to combat disease. We have screened plasma from >100 acutely infected and convalescent COVID-19 individuals for neutralization…
Patrizia Farci · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $47,982 — 1. Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants A. Generation and characterization of anti-SARS-CoV-2 mAbs using phage-display libraries from COVID-19 convalescent patients. Peripheral blood samples were collected from 12 convalescent COVID-19 patients…
David Sacks · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $114,312 — Our initial experiments involving the transgenic L. major lines overexpressing spike protein, either the full length S gene sequence or secreted S1/S2 subunits, showed that in each case the clones were attenuated in mice. New transgenic lines were generated: the full length S gene sequence was ampl…
Clare Michal Waterman · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2023 · $1,036,270 — Project: MARK2/Par1b regulates cytoskeleton polarization and directed cell migration through modulation of Myosin II contractility and focal adhesion organization. Personnel: Ana Pasapera Collaborators: Sarah Heissler, Masumi Eto Goal: We sought to test the hypothesis that MARK2 mediates polariza…
Duane R. Wesemann · BRIGHAM AND WOMEN'S HOSPITAL · 2023 · $3,175,901 — PROJECT 1 SUMMARY Global establishment of Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is a continued human threat. While successful vaccine programs are well underway, genetic drift and immune escape have already begun to subvert immunity. In addition, related zoonotic coronaviruses…
Viviana A Simon · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $253,527 — The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for better understanding of the mechanisms controlling broadly protective immune responses and generating vaccine candidates able to elicit such responses. The program project entitled “Programming Long-last…
Ali Hassan Ellebedy · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $208,535 — The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for better understanding of the mechanisms controlling broadly protective immune responses and generating vaccine candidates able to elicit such responses. The program project entitled “Programming Long-last…
Devdoot Majumdar · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2023 · $226,930 — PROJECT SUMMARY: Devdoot Majumdar, PhD, Research Project Leader (RPL) The mRNA vaccines against SARS-CoV-2 proved unexpectedly efficacious, but also require a series of booster immunizations to remain protective. Global deployment of these vaccines has been slow, particularly in low- and middle-inco…
Kevin Wiehe · DUKE UNIVERSITY · 2023 · $2,828,814 — Abstract – Project 2 Animal betacoronaviruses (betaCoVs), such as those that gave rise to SARS-CoV-1, MERS, and now SARS- CoV-2, represent a significant, continuous threat to human health. Vaccines can provide pre-existing immunity to future zoonotic coronaviruses. A major limitation of the current …
Rory Henderson · DUKE UNIVERSITY · 2023 · $966,626 — Abstract - Project 4 SARS-CoV-2, a member of the genus Betacoronavirus (betaCoV), is the third major zoonotic outbreak of a highly pathogenic betaCoV in the last two decades. We propose to design vaccines to contribute to the global effort to counter the COVID-19 pandemic as swiftly as possible, and…