Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kirk David Christian Jensen · UNIVERSITY OF CALIFORNIA, MERCED · 2024 · $219,554 — PROJECT SUMMARY_____________________________________________________________________ Parasitic diseases remain a problem worldwide largely due to the lack of vaccines to effectively interrupt transmission or infection, as parasites often develop resistance to drugs. A combination of different factor…
Ross M Kedl · UNIVERSITY OF COLORADO DENVER · 2024 · $460,469 — PROJECT SUMMARY Due to the overwhelming success of the new mRNA vaccines during the SARS-CoV2 pandemic, vaccines have entered the public consciousness to a level not seen since the days of smallpox eradication and the polio epidemic. It seems reasonable to assume that the established rules governing…
CAROLINE E CAMERON · UNIVERSITY OF VICTORIA · 2024 · $1,622,474 — PROJECT SUMMARY In several high-income nations, including the United States, infectious syphilis has been resurgent for over two decades now, while syphilis is still endemic in low- and middle-income countries. Syphilis is therefore still a public global health concern, particularly because it can …
JOSHUA D NOSANCHUK · FUNDACAO OSWALDO CRUZ · 2024 · $115,880 — An extracellular vesicle component as a candidate to control cryptococcosis. SUMMARY Fungal diseases are a major threat to immunocompromised patients. Cryptococcosis, caused by members of the Cryptococcus genus, is responsible for nearly 200,000 deaths worldwide annually. Immunocompromised individua…
Michael R. Farzan · BOSTON CHILDREN'S HOSPITAL · 2024 · $265,500 — ABSTRACT Both private entities and academic groups are pioneering B cell editing for therapeutic purposes, either to express therapeutic antibodies from their native Ig loci, or other transgenes from an ectopic locus. BCR editing is currently performed with CRISPR/Cas system and a homology- directed…
Paolo Cravedi · PALO ALTO VETERANS INSTIT FOR RESEARCH · 2023 · $255,459 — PROJECT SUMMARY / ABSTRACT Solid organ transplant recipients have increased morbidity and mortality in response to infection with SARS- CoV-2, the virus responsible for COVID19. While the general population has greatly benefited from the rapid development of several vaccines that are protective agai…
James Lai · TRULY TECHNOLOGIES LLC · 2023 · $272,625 — PROJECT SUMMARY/ABSTRACT Urine is an attractive biospecimen for point-of-care diagnostics because it can be collected in large quantities with noninvasive procedures. Urine-based lateral flow assays (LFAs) are low-cost devices suitable for point-of-care testing, particularly in low-resource settings…
Jianfa Bai · KANSAS STATE UNIVERSITY · 2023 · $73,194 — Project Summary: SARS-CoV-2 is a major human respiratory pathogen that can cause COVID-19, a disease with symptoms similar to those caused by Influenza A (Flu A) and Influenza B (Flu B) viruses. A few major SARS-CoV-2 variants of concern (VOC) have been identified and associated with increased trans…
Joyce Sooyeon Kim · JOHNS HOPKINS UNIVERSITY · 2023 · $69,500 — PROJECT SUMMARY Activation of sensory nerves, in particular nociceptive C-fibers, is a feature of most respiratory viruses. Evidence of such activation is found in the classical consequences of C-fiber activation including sneezing, sore throat, coughing, and reflex secretions. As well as causing th…
Luis J Sigal · THOMAS JEFFERSON UNIVERSITY · 2023 · $722,737 — Summary CD8 T-cells recognize and kill virus-infected cells displaying at the cell surface short viral peptides bound to major histocompatibility (MHC) class I molecules (MHC-I). CD8 T-cells contribute to the clearance of many viral infections. After an infection subsides, an expanded population of…
Hawa Vahed · TECHIMMUNE, LLC · 2023 · $300,000 — SUMMARY Over the last 2 years humanity has been confronting COVID-19 pandemic caused by the new Corona Virus 2 (SARS-CoV-2) infection. Major gaps: Mutations and deletions often occur in the genome of SARS-CoV-2 (predominantly in the Spike protein) resulting in more transmissible and pathogenic “vari…
ELAN Z EISENMESSER · UNIVERSITY OF COLORADO DENVER · 2023 · $233,250 — PROJECT SUMMARY Coronaviruses (CoVs) have emerged as formidable human pathogens since their detection within human populations only 50 years ago, underlying the need to rapidly characterize their molecular mechanisms in order to thwart their infections through therapeutics. Seven CoVs that infect h…
MALINI RAGHAVAN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2023 · $227,280 — CD8+ T cells recognize short peptide antigens in the context of major histocompatibility complex class I (MHC- I) proteins. Three sets of genes, the human leukocyte antigens (HLA) HLA-A, HLA-B and HLA-C encode the heavy chains of human MHC-I (HLA-I) proteins, which also contain a light chain (β2-mic…
Bryan A Johnson · UNIVERSITY OF TEXAS MED BR GALVESTON · 2023 · $497,886 — Abstract The coronavirus (CoV) spike protein is a key viral determinant responsible for receptor binding and fusion/entry. The spike protein has also been predicted to be the major factor driving cross-species transmission, allowing the emergence of epidemic strains like SARS- and MERS-CoV. In the f…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2023 · $2,208,763 — UNAIDS has documented millions of new HIV-1 infections every year, thus a vaccine for HIV-1 is highly desirable. To date, despite numerous efforts, no immunization regimen reproducibly elicits broadly neutralizing antibodies (bNAbs) against HIV-1. Recently available native-like HIV-1 envelope spike …
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2023 · $816,248 — Project Summary The first critical step for enveloped viruses, such as HIV-1, to enter host cells is viral membrane fusion. Viral fusion proteins are fascinating protein folding machineries capable of adopting completely different conformations during the fusion process; they are also important vac…
Lin Gan · AUGUSTA UNIVERSITY · 2023 · $192,500 — PROJECT SUMMARY / ABSTRACT Taste deficits are prevalent in people infected with SARS-CoV-2, the virus responsible for the global COVID-19 pandemic. The loss of taste sensation negatively affects nutrition and quality of life and in some patients this deficit is long-lasting. The biological basis for…
Sagar D Khare · RUTGERS, THE STATE UNIV OF N.J. · 2023 · $236,919 — The ongoing rapid and widespread transmission of SARS-CoV-2 across the world has resulted in myriad viral strains, but human immunity has been acquired from vaccination against a single (Wuhan-Hu-1) strain and/or previous infection with a handful of strains. The large number of substitutions present…
Nicholas Stephanopoulos · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2023 · $296,022 — Project Summary Protein-protein interactions (PPIs) drive countless processes in biology. The ability to block these interactions with high specificity is crucial for probing the basic science of these processes, as well as for developing imaging agents or novel therapeutics. However, most tradition…
JOHN H KEHRL · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $154,304 — Beta-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our recent studies have focused on two SARS-CoV-2 encoded proteins, open reading frame (ORF) 3a and 8. Previous studies of SARS-CoV-1 identified O…