NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Tejal A. Desai · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $805,361 — PROJECT SUMMARY: The COVID-19 pandemic, caused by the new coronavirus SARS-CoV-2, has had a remarkable impact on public health worldwide with the largest number of cases and deaths reported in the United States. Improved understanding of COVID-19 will accelerate the development of effective therapeu…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2023 · $531,000 — Project Summary Membrane fusion, mediated by HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], is the first critical step for the virus to enter host cells and establish infection. A mature Env spike contains three copies each of noncovalently-associated receptor-binding…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Mohammad Mohseni Sajadi · BALTIMORE VA MEDICAL CENTER · 2023 — Background/Rationale: As the Coronavirus Disease 2019 (COVID-19) epidemic expands across the United States and the world, there are no proven therapies and little information is known regarding on immunity to this virus. At this stage of the pandemic, all prevention and treatment strategies that sho…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
TREVOR P. CASTOR · APHIOS CORPORATION · 2023 · $300,000 — PROJECT SUMMARY COVID-19, the multiorgan disease caused by the novel coronavirus SARS-CoV-2, has become the most impactful healthcare, social, and economic crisis of our lifetime. SARS-CoV-2 is genetically related to the previous two coronaviruses that caused human outbreaks in the 21st century, SAR…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
TIONE BURANDA · TULANE UNIVERSITY OF LOUISIANA · 2023 · $2,254,100 — ABSTRACT Rapidly emerging evidence has characterized the association between vascular dementia (VaD) and increased COVID-19 incidence, morbidity, and post-COVID cognitive decline. We theorize that brain vascular pathology in VaD and additional pathophysiologic features such as blood-brain barrier (B…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Raiees Ahmad Andrabi · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $805,612 — PROJECT SUMMARY/ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified at the end of 2019, has led to the current global pandemic. The SARS-CoV-2 virus belongs to the subgenus sarbecovirus of the genus betacoronavirus, the genus from which two SARS-CoV-…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
DAVID BAKER · UNIVERSITY OF WASHINGTON · 2023 · $703,773 — PROJECT SUMMARY One of the most pressing public health priorities for the COVID-19 pandemic is the development of an effective and inexpensive therapeutic. The long-term goal of this proposal is to develop such COVID-19 treatments, as well as the methods needed to rapidly create such molecules as so…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
GARY B RUVKUN · MASSACHUSETTS GENERAL HOSPITAL · 2023 · $431,960 — Project Summary/Abstract: Our discovery that the NGLY1/PNG-1 deglycosylation enzyme mediates the protein editing of N- glycosylated asparagines to aspartic acid of the SKN-1A transcription factor to increase proteasomal capacity is highly relevant to protein aggregation diseases, such as Alzheimer’s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Marisa L. Zallocchi · CREIGHTON UNIVERSITY · 2023 · $520,111 — ABSTRACT. An organism’s perception of its surrounding environment depends on the sensory function. Neurosensory cells from the inner ear are involved in key biological processes associated with hearing and balance. To be able to achieve their function these cells depend on a complex array of membran…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Ivan Zanoni · BOSTON CHILDREN'S HOSPITAL · 2023 · $748,825 — PROJECT SUMMARY Vaccines represent a highly effective public health measure to protect individuals from infectious diseases. Many vaccines work by inducing antigen-specific antibodies that neutralize the pathogen or its products and promote their clearance. Vaccines based on protein antigens usually…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Chao Wang · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2023 · $189,242 — Project Summary/Abstract As of mid June 2021, the new coronavirus disease (COVID-19), caused by SARS-CoV-2 virus, has infected ~180 million people and causing ~3.8 million deaths globally. There are more than 34 million confirmed cases and ~620,000 deaths in the U.S alone. The fast transmission, as…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Daniel A Hammer · UNIVERSITY OF PENNSYLVANIA · 2023 · $203,125 — Summary Severe respiratory acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a world-wide pandemic causing over 525K deaths in the U.S. and over 2.6M deaths world-wide as of this writing. Here, we propose to make phospholipid vesicles and other related nanostructures (d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Megan A O'Connor · UNIVERSITY OF WASHINGTON · 2023 · $353,000 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccination is safe, immunogenic, and durable in individuals with treated and virally suppressed HIV infection but is less immunogenic in immunosuppressed individuals and those with unsuppressed HIV infection. The rollout of COVID-19 vaccines is still limited in cou…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Adrianus CM Boon · WASHINGTON UNIVERSITY · 2023 · $581,630 — PROJECT SUMMARY SARS-CoV-2 has led to unprecedented disruptions to society, killing more than 6 million people worldwide. It is a respiratory virus whose main mode of transmission is via respiratory droplets and aerosols. Social distancing and vaccines have greatly decreased the rate of infection an…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Siyuan Ding · WASHINGTON UNIVERSITY · 2023 · $233,250 — Rotavirus (RV) is a major etiological cause of severe gastroenteritis and diarrhea worldwide, resulting in the death of more than 200,000 children each year. Current RV vaccines have limited efficacy in endemic countries and no direct antivirals are available. Our overall objective is to better unde…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Amit Praful Khandhar · HDT BIO CORPORATION · 2023 · $940,253 — Project Summary/Abstract A key requirement for HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope (Env) spike. The BG505 SOSIP.664 gp140 soluble timer is engineered to display conformational epitopes recognized by several bNAbs but not …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
MANOJ K PATEL · UNIVERSITY OF VIRGINIA · 2023 · $399,015 — Epilepsy is a major economic and personal burden for the American public, affecting over 3 million Americans (1-2% of the population) with over 200,000 new cases diagnosed each year. There is no cure for epilepsy. Seizures can only be suppressed using antiepileptic drugs. Unfortunately, these drugs …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
YUYING LIANG · UNIVERSITY OF MINNESOTA · 2023 · $232,500 — Abstract The COVID-19 pandemic has had a profound, global impact on public health. Of the 120,000,000 cases documented world-wide, over 30 million cases have occurred in the Unites States, with >530,000 COVID deaths to date. Considerable progress in control of the pandemic has been realized in the U…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Gabriel D Victora · ROCKEFELLER UNIVERSITY · 2023 · $628,260 — PROJECT SUMMARY Generating an appropriate antibody response is critical for protection against reinfection and for the effectiveness of vaccination, particularly in the context of viral diseases. In addition to well-studied quantitative parameters such as antibody titer and affinity, other, more qua…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2023
Hideki Aihara · UNIVERSITY OF MINNESOTA · 2023 · $619,646 — Abstract Viruses are a major threat to human health. Our laboratory uses various structural biology techniques to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. One area of our major interest is retroviral integration, a critical step in the lifecycle o…