Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Scott G Hansen · OREGON HEALTH & SCIENCE UNIVERSITY · 2019 · $790,163 — DESCRIPTION (provided by applicant): The development of an effective HIV/AIDS vaccine remains a high international health priority as the most cost-effective means to stem the AIDS pandemic. At this point in time, there are very few general HIV/AIDS vaccine strategies that remain viable for cli…
VICTOR Robert DEFILIPPIS · OREGON HEALTH & SCIENCE UNIVERSITY · 2019 · $716,448 — PROJECT SUMMARY The goals of this R01 proposal include the molecular and immunological characterization of vaccine adjuvant activity associated with processes mediated by the protein Stimulator of Interferon Genes (STING). Two vital insufficiencies are currently evident regarding adjuvanted human va…
JEANNE ANN JORDAN · GEORGE WASHINGTON UNIVERSITY · 2019 · $359,512 — ABSTRACT Human papillomavirus (HPV) infections are highly prevalent in men and women. High-risk (HR) HPV types 16 & 18 (HPV16/18) are responsible for ~90% of all anal cancers, whose incidence has risen by 96% in the last 2- 3 decades primarily because of the HIV/AIDS epidemic. Indeed, HIV-infected m…
W. Henry Boom · CASE WESTERN RESERVE UNIVERSITY · 2019 · $731,718 — DESCRIPTION (provided by applicant): Tuberculosis (TB) is a major public health burden globally. After close contact with a person with pulmonary TB, most people become infected by inhaling aerosolized Mycobacterium tuberculosis (MTB). Most control this infection without eliminating it and develop l…
John Thomas Patton · TRUSTEES OF INDIANA UNIVERSITY · 2019 · $223,889 — Rotaviruses, a large and genetically diverse group of segmented double-stranded (ds)RNA viruses, are a significant cause of gastroenteritis in many mammalian and avian species. Among infants and young children, rotavirus infections can result in life-threatening dehydrating diarrheal disease. Like o…
David M Koelle · UNIVERSITY OF WASHINGTON · 2019 · $173,983 — Project Summary: The waning of immunity has a major impact on morbidity and mortality in the aged. Antigen-specific, acquired, and especially T-cellular is important in host defense against chronic intracellular pathogens and cancer. Infections with these microbes and skin cancers with high mutation…
Wen Jiang · UT SOUTHWESTERN MEDICAL CENTER · 2019 · $253,377 — Project Summary Despite significant advances in the treatment of breast cancer, the metastatic form of the disease remains highly lethal, with a 5-year overall survival rate of only around 20%. Even with the use of new, targeted therapies such as antibodies against the human epidermal receptor 2 (H…
Christophe Queva · ONCORUS, INC. · 2019 · $299,976 — The most aggressive form of brain malignancies, glioblastoma multiforme (GBM) represents a particularly acute unmet medical need. GBM are highly invasive and do not respond to immune checkpoint inhibition due to their suppressive microenvironment. Oncolytic viruses engineered to selectively replicat…
Jilian R Melamed · CARNEGIE-MELLON UNIVERSITY · 2019 · $61,226 — While gene therapy with mRNA offers tremendous potential to transform the management of genetic diseases, delivering mRNA outside the reticuloendothelial system (e.g. liver and spleen) remains challenging. Without carriers that can reach organs such as the lungs, heart, brain, or pancreas, the poten…
YASUHIRO SUZUKI · UNIVERSITY OF KENTUCKY · 2019 · $459,000 — Chronic infection with Toxoplasma gondii can reactivate and cause life-threatening toxoplasmic encephalitis in AIDS patients and other immunocompromised individuals. The basis of persistence of this chronic infection is the tissue cyst. Thus, eliminating T. gondii cysts from chronically infected ind…
WILLIAM R. SCHIEF · SCRIPPS RESEARCH INSTITUTE, THE · 2019 · $957,981 — Induction of broadly neutralizing antibodies (bnAbs) is a critical unmet goal of HIV vaccine development. BnAb 10E8 is of particular interest as a vaccine lead due to its (1) very high breadth, (2) low number of mutations required to develop broad neutralization, (3) low auto-reactivity, (4) expe…
Jianrong Li · OHIO STATE UNIVERSITY · 2019 · $498,053 — Abstract This application is to renew a grant to study RNA methylation in pneumoviruses. Pneumoviridae is a new virus family, created in 2016 by elevating the paramyxoviral subfamily Pneumovirinae to family status. The Pneumoviridae family includes two medically important pathogens, human respirator…
ANDREW W GRIMSON · CORNELL UNIVERSITY · 2019 · $342,445 — Project Summary /Abstract Neonates are highly susceptible to infection and respond poorly to vaccination for reasons that are not well understood. Based on our published data, we believe that neonates are particularly vulnerable to repeat infections because their naïve CD8+ T cells are intrinsically…
Nilabh Shastri · JOHNS HOPKINS UNIVERSITY · 2019 · $543,021 — Unconventional sources of peptides for antigen presentation Project Abstract The long term goals of this project are to understand how the antigen processing pathway generates peptide/MHC class I complexes (pMHC I) by cryptic translation. Numerous studies, from different laboratories, have shown th…
PETER LEON COLLINS · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2019 · $1,332,368 — We previously performed (in collaboration with NCATS, the NIH National Center for Advancing Translational Sciences) a genome-wide high-throughput siRNA screen of 21,500 cellular genes to identify ones involved in RSV infection. Human airway epithelial A549 cells in vitro were engineered to express D…
ROBERT L DANNER · CLINICAL CENTER · 2023 — Nitric oxide (NO): NO upregulates TNFa production (J Immunol 1994; Blood 1997) through a cGMP-independent pathway (J Biol Chem 1997; J Biol Chem 1999; J Biol Chem 2003), while ROS from eNOS uncoupling upregulates TNFa (J Biol Chem 2000) through ERK1/2 (Am J Physiol 2001). NO activation of p38 MAPK s…
John Schneekloth · DIVISION OF BASIC SCIENCES - NCI · 2023 · $325,082 — Traditional drug screening strategies are based on targeting coronavirus-related proteins (e.g., RdRp, Mpro, and 3CLpro) and receptors (e.g. ACE2). In addition to virus-coded proteins, RNA structures within the SARS-CoV-2 genome also regulate essential functions and are potentially attractive and co…
Noha Shawky · UNIVERSITY OF MISSISSIPPI MED CTR · 2023 · $268,861 — Polycystic ovary syndrome (PCOS), the most common endocrine disorder in young women, is characterized by hyperandrogenemia and metabolic dysfunction. PCOS women who become pregnant may have offspring born with low birth weight (LBW), associated with increased risk for cardiovascular (CV) disease (…
Tara F Carr · UNIVERSITY OF ARIZONA · 2023 · $255,048 — The overall goal of this Asthma and Allergic Diseases Cooperative Research Center (AADCRC) proposal is to elucidate the mechanisms by which the innate immune system affords protection against viral-induced exacerbations in asthma. In the renewal of our AADCRC program, we will continue to focus on th…
JOHN P COOKE · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $732,287 — ABSTRACT Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered Vein-Chip Challenge: Increasing evidence shows that SARS-CoV-2, which is the novel coronavirus that causes COVID- 19, is able to trigger the formation of blood clots within the veins of patien…