Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Vaithilingaraja Arumugaswami · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $2,378,661 — Project Summary/Abstract SARS-CoV-2 primarily affects the respiratory system but extra-pulmonary manifestations in individuals with COVID-19 are commonly seen. All major organ systems have been reported to be affected by SARS-CoV-2 and complications arising from ensuing organ dysfunction significant…
Monica Kraft · UNIVERSITY OF ARIZONA · 2023 · $469,477 — During the first cycle of our AADCRC program, our project focused primarily on Surfactant Protein A (SP-A), a known innate immune modulator that exhibits important anti-inflammatory effects in asthma. In this renewal, we show preliminary data that SP-A binds the interleukin (IL)-6 receptor and disru…
Montserrat C Anguera · UNIVERSITY OF PENNSYLVANIA · 2023 · $201,063 — Project Summary COVID-19, the disease caused by the SARS-CoV-2 virus, commonly presents as pneumonia, with those most severely affected progressing to Acute Respiratory Distress Syndrome (ARDS). Notably, males seem to be at significantly higher risk for severe or fatal outcomes from COVID-19, and ma…
Shelli Farhadian · YALE UNIVERSITY · 2023 · $417,822 — Project Summary The COVID-19 pandemic has rampantly affected the population of the world and created lasting effects on the economy, health and psyche of the global community. Although it shares similarities with SARS-CoV-1, the full extent of the pathophysiology caused by SARS-CoV-2 is unclear. In …
Peter M Tessier · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2023 · $185,721 — Emerging SARS-CoV-2 variants are of broad interest because they may be more resistant to current vaccines and associated immune responses. Toward the long-term goal of understanding how receptor-binding domain (RBD) mutations impact transmissibility, it is critical to elucidate the impacts of RBD mu…
Peixin Yang · UNIVERSITY OF MARYLAND BALTIMORE · 2023 · $400,000 — SARS-CoV-2 infection induces activation of ferroptosis in the placenta Summary Pregnancy is a risk factor for SARS-CoV-2 infection and worse COVID-19 outcomes. Therefore, there is an urgent need for research into underlying mechanisms leading to the pathogenesis of adverse pregnancy outcomes and the…
Minolfa C Prieto · TULANE UNIVERSITY OF LOUISIANA · 2023 · $197,869 — ABSTRACT/SUMMARY The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), etiologic agent of the COVID-19, is the cause of the current worldwide pandemic with unprecedented public health issues. The lung is the most severely injured organ by SARS-CoV-2, but the kidney appears to be damaged…
Beverly H Koller · UNIV OF NORTH CAROLINA CHAPEL HILL · 2023 · $233,250 — Summary The cell and tissue tropism of viruses is defined as the capacity of a virus to infect specific cells and tissues and is determined by both viral and cellular factors. An important factor for initiation of infection is cell entry, which is dependent on the ability of the virus to dock with i…
Kelly M. Reavis · PORTLAND VA MEDICAL CENTER · 2023 — Project Background/Rationale: The purpose of this proposal is to quantitatively examine and qualitatively understand the impact of COVID-19 on Veterans' auditory function. Since the pandemic began, over 230,000 Veterans in the VA health care system have tested or been presumed positive for COVID-19.…
KENNETH E BERNSTEIN · CEDARS-SINAI MEDICAL CENTER · 2023 · $566,378 — A long sought goal of medical research is to identify ways to increase the effectiveness of the immune response. Here, we present a means of increasing myeloid cell function by increasing cell expression of angiotensin converting enzyme (ACE). We show that 1) under natural circumstances in both huma…
Lawrence James Purpura · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2023 · $192,102 — PROJECT SUMMARY/ABSTRACT: Rationale: The COVID-19 pandemic has affected over 42 million individuals in the United States and long-term complications are frequently reported, referred to as post-acute sequelae of SARS-CoV-2 (PASC). Even among survivors with mild acute illness, neurologic symptoms suc…
MICHAEL FRANCIS BEERS · PHILADELPHIA VA MEDICAL CENTER · 2023 — ABSTRACT The Severe Acute Respiratory Syndrome (SARS)-associated coronavirus 2 (SCoV2) is the cause of COVID-19 syndrome which is marked by a refractory acute lung injury that results in dramatic hypoxic respiratory failure and high mortality. Despite the recurrent health and economic devastation pr…
Alexander H Flannery · UNIVERSITY OF KENTUCKY · 2023 · $157,563 — PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in sepsis-associated acute kidney injury (SA-AKI). The candidate is currently an Assistant Professor at the University of Ke…
Laurent Olivier Mosnier · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $452,500 — Project Summary This application seeks to improve basic understanding of the molecular mechanisms that mediate cytoprotective actions of coagulation proteases on cells and will test novel approaches for the potential treatment of thrombo- inflammatory disease. Despite recent advances, major gaps in …
Edward Lakatta · NATIONAL INSTITUTE ON AGING · 2023 · $342,724 — Some projects that require expertise in microRNAs and, specifically, in miR-200 family and miR-34a, have been initiated. It has been shown that miR-200 family members (co-transcribed miR-200c, -141; co-transcribed miR-200b, -200a, -429) and miR-34a increase in response to oxidative stress suggesting…
Heather Hickman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $267,943 — The emergence of SARS-CoV-2 in human populations in 2019 has resulted in a global pandemic with staggering morbidity and mortality. In humans, coronavirus-induced disease 2019 (COVID-19) is characterized by decreased lung function and increased pro-inflammatory cytokine production. As the immune m…
Tian Jin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $70,231 — We have started the project Identification of co-receptor and components involved in the entry of SARS-CoV-2 using a quantitative phosphoproteomic approach. We developed a mass-spectrometry method to detect changes of protein phosphorylation in live cells upon stimulations. This method combines ta…
Vincent Munster · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,096,841 — The research program of the Virus Ecology Section (VES) is focused at understanding the drivers of virus emergence. Upon the emergence of SARS-CoV-2 in 2019, the research we swiftly pivoted to SARS-CoV-2. We were the first was to establish ACE2 as the SARS-CoV-2 receptor and rapidly developed a no…
Daniel Barber · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $163,023 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a spectrum of clinical outcomes, ranging from asymptomatic to fatal. There is a need to parse out the role of individual immune cell types and molecular pathways that contribute to effective control of viral infection in asym…
Pedro A Piedra · BAYLOR COLLEGE OF MEDICINE · 2023 · $356,847 — PROJECT SUMMARY – Project 2 Respiratory syncytial virus (RSV) is a major global respiratory pathogen. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has resulted in an unprecedented crisis. Respiratory virus infections are often accompanied by gastrointestinal (GI) symptom…