Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kurt Jarnagin · SYNBAL, INC. · 2022 · $1,000,000 — Abstract Phase I/II Synbal and the La Jolla Institute for Immunology (LJI) are combining efforts to create breakthrough new tools for COVID-19 research to enhance research and drug development for COVID-19 disease. We aim to create a state-of-the-art set of humanized mouse strains susceptible to SAR…
Kristen Knutson · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $631,557 — There is a fundamental gap in our understanding of the neurological manifestations of post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Neuro-PASC consists in a wide array of symptoms affecting patient’s cognition and quality of life, as well as their ability to work. Up to 85% of Neuro-PASC…
CARLOS M FERRARIO · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2022 · $193,750 — Project Summary The burden of high blood pressure, a major public health problem, is aggravated by an aging human population. A plethora of experimental data points to angiotensin II (Ang II), as the major contributing factor in the development of hypertension-related target organ damage. Although …
Christopher L King · CASE WESTERN RESERVE UNIVERSITY · 2022 · $679,626 — The duration and nature of humoral immunity to SARS-CoV-2 (CoV2) infection is poorly understood. Most studies have focused on the immune response in patients with clinical illness, but little is known about antibody response to CoV2 regarding the earliest immunological events immediately after expos…
Roman Pogranichniy · KANSAS STATE UNIVERSITY · 2022 · $225,000 — Project Summary SARS-CoV-2 is an enveloped, positive-sense RNA virus that is known to interact with the angiotensin- converting enzyme-2 (ACE2) receptor of several species, including humans, cats, dogs, minks, ferrets, deer, and others. Since its emergence in Wuhan, China in late 2019, SARS-CoV-2, t…
DAVID G BESSELSEN · UNIVERSITY OF ARIZONA · 2022 · $306,997 — ABSTRACT The pandemic COronaVIrus disease 2019 (COVID-19) is an infectious disease, which is caused by a novel and highly pathogenic virus strain SARS-CoV-2 (Severe acute respiratory virus syndrome coronavirus 2). The infection may cause severe lower respiratory tract infection with acute respirator…
Shelli Farhadian · YALE UNIVERSITY · 2022 · $70,603 — Project Summary The COVID-19 pandemic has rampantly affected the population of the world and created lasting effects on the economy, health and psyche of the global community. Although it shares similarities with SARS-CoV-1, the full extent of the pathophysiology caused by SARS-CoV-2 is unclear. In …
Xuyi Yue · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · 2022 · $177,500 — PROJECT SUMMARY The coronavirus disease2019 (COVID-19) pandemic is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). New COVID-19 cases and COVID-19 related deaths continue to rise rapidly and no effective drugs or vaccines are currently available…
KATHLEEN E. RODGERS · UNIVERSITY OF ARIZONA · 2022 · $383,750 — Activation of brain inflammatory pathways contributes to amyloid accumulation, neuronal dysfunction, cognitive impairment, and memory loss which are the main pathological features of Alzheimer's disease (AD). There are few treatments for AD and those available have limited utility. As a result, ther…
Sergiy Gychka · GEORGETOWN UNIVERSITY · 2022 · $163,800 — Summary/Abstract Currently the world is suffering from the pandemics of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter host cells. Millions of people have been infect…
Yong Huang · UNIVERSITY OF FLORIDA · 2022 · $176,608 — Project Summary The overarching goal of this research is to fabricate an in vitro three-dimensional (3D) human respiratory model with an air-liquid interface (ALI), which can serve as a platform for COVID-19 related biomedical investigations. A recent COVID-19 outbreak, which is due to the infection…
Todd B Reynolds · UNIVERSITY OF TENNESSEE KNOXVILLE · 2022 · $497,866 — Candida albicans and related Candida spp. are responsible for ~400,000 invasive infections/year, which have an ~50% mortality rate. A crucial virulence trait of C. albicans, and other fungi, is the ability to diminish their detection by their hosts. The cell wall carbohydrate ß(1,3)-glucan is an imp…
Minolfa C Prieto · TULANE UNIVERSITY OF LOUISIANA · 2022 · $235,276 — ABSTRACT/SUMMARY The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), etiologic agent of the COVID-19, is the cause of the current worldwide pandemic with unprecedented public health issues. The lung is the most severely injured organ by SARS-CoV-2, but the kidney appears to be damaged…
Asrar B. Malik · UNIVERSITY OF ILLINOIS AT CHICAGO · 2022 · $730,601 — ABSTRACT Human induced pluripotent stem cells (iPSCs) can be used to generate 3-dimensional lung organoid structures. However, most lung organoid studies have focused on human iPSC-derived lung epithelial subtypes. They have not to date included human iPSC-derived endothelial cells and systematical…
Chiara Giannarelli · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $803,677 — PROJECT SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global health concern and despite the fast-track development of vaccines and the imminent prospective of new antiviral drugs, is expected to become ende…
CALVIN J KUO · STANFORD UNIVERSITY · 2022 · $393,500 — ABSTRACT The COVID-19 pandemic, engendered by the novel coronavirus SARS-CoV-2, is a grave threat to public health, with lung infection and respiratory failure. However, the intestine is also targeted by SARS-CoV-2, as many patients present with GI symptoms and the SARS-CoV-2 receptor angiotensin-co…
YOSHIHIRO KAWAOKA · UNIVERSITY OF WISCONSIN-MADISON · 2022 · $233,250 — PROJECT SUMMARY The pandemic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus can cause severe and even fatal infections in some patients, primarily those with comorbidities such as hypertension, diabetes mellitus, obesity, and cardiovascular disease. In addition, immunocompromise…
Montserrat C Anguera · UNIVERSITY OF PENNSYLVANIA · 2022 · $241,688 — Project Summary COVID-19, the disease caused by the SARS-CoV-2 virus, commonly presents as pneumonia, with those most severely affected progressing to Acute Respiratory Distress Syndrome (ARDS). Notably, males seem to be at significantly higher risk for severe or fatal outcomes from COVID-19, and ma…
MARK C CHAPPELL · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2022 · $774,719 — ABSTRACT Hypertension is the leading risk factor for cardiovascular disease, is highly prevalent with high lifetime cumulative incidence rates, and is the leading cause of death compared to any other risk factor. Premature birth is an emerging and important risk factor for hypertension and cardiovas…
ROBERT M LAVKER · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $397,702 — PROJECT SUMMARY/ABSTRACT The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying structures from injury, in part, through the elaboration of the limbal and corneal epithelia. It is well- accepted that the limbal epithelium is the site o…