Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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Eric D Lazartigues · LSU HEALTH SCIENCES CENTER · 2022 · $578,289 — With prevalence as high as 55% for individuals aged 55 and older in United States, hypertension (HTN) is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. The role of the brain renin-angi…
Qizhi Gong · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $196,250 — PROJECT SUMMARY A sudden onset of olfactory impairment is reported as one of the early clinical manifestations of COVID-19, particularly among mild and asymptomatic patients. Though reports indicate that olfactory loss resolves within two weeks, it is unknown what proportion of the patients develops…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2022 · $649,870 — Project Summary/Abstract This R01 entitled, “Development and characterization of engineered therapeutic antibodies against SARS-CoV- 2”, builds on our project infrastructure, expertise, and experience in characterizing viral-host factor interactions in negative strand RNA viruses. Since originating …
KENNETH E BERNSTEIN · CEDARS-SINAI MEDICAL CENTER · 2022 · $555,387 — A long sought goal of medical research is to identify ways to increase the effectiveness of the immune response. Here, we present a means of increasing myeloid cell function by increasing cell expression of angiotensin converting enzyme (ACE). We show that 1) under natural circumstances in both huma…
Prasant Mohapatra · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $297,763 — Summary The COVID-19 pandemic constitutes a significant challenge to health care systems in the United States and abroad. A systemic compromise of the organism following SARS-CoV-2 infection has emerged as an important factor associated with COVID-19 severity, disproportionally affecting older patie…
Yuebing Zheng · UNIVERSITY OF TEXAS AT AUSTIN · 2022 · $379,952 — PROJECT SUMMARY This R01 application is responsive to the NIH initiative PAR-19-253 “Focused Technology Research and Development”. Assays for measuring receptor-ligand affinity are valuable in many areas of biomedical research. The “gold standard” surface plasmon resonance assay is limited to recomb…
DANIEL BATLLE · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $320,000 — Project summary Delayed graft function (DGF) is a form of acute kidney injury clinically defined as the need for dialysis within one week of kidney transplantation. It affects up to 50% of deceased-donor kidney transplant recipients. Because of the organ shortage crisis, marginal or expanded criteri…
Shelli Farhadian · YALE UNIVERSITY · 2022 · $417,822 — Project Summary The COVID-19 pandemic has rampantly affected the population of the world and created lasting effects on the economy, health and psyche of the global community. Although it shares similarities with SARS-CoV-1, the full extent of the pathophysiology caused by SARS-CoV-2 is unclear. In …
Ralph S Baric · WASHINGTON UNIVERSITY · 2022 · $1,202,440 — Project Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that was first isolated in Wuhan China in December, 2019. SARS-CoV-2 is the cause of coronavirus disease 2019 (COVID-19), which is now a pandemic and has caused more than 1.3 mi…
Hong Wang · MONELL CHEMICAL SENSES CENTER · 2022 · $423,308 — PROJECT SUMMARY SARS-CoV-2 has infected >340 million people worldwide, including >70 million Americans. Roughly 40-45% of these patients have reported taste abnormalities. While taste function is restored quickly in many patients, recent studies show that about 10-20% of patients suffer from sustain…
Alexander H Flannery · UNIVERSITY OF KENTUCKY · 2022 · $157,563 — PROJECT SUMMARY/ABSTRACT This proposal includes a five-year research career development program to study classical and alternative renin-angiotensin system (RAS) dysregulation in sepsis-associated acute kidney injury (SA-AKI). The candidate is currently an Assistant Professor at the University of Ke…
Ekaterina Koroleva · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2022 · $228,911 — Lung immunopathology is a major cause of the morbidity and mortality associated with the SARS-CoV-2 infection. Accumulating evidence suggests that SARS-CoV-2-associated lung damage is caused not only by the virus, but also by excessive production of proinflammatory cytokines, known as cytokine storm…
Swati S More · UNIVERSITY OF MINNESOTA · 2022 · $589,000 — ABSTRACT Angiotensin-converting enzyme (ACE) plays a well-established role in regulating blood pressure in the periphery. ACE is also expressed in the brain, with high levels in the striatonigral pathway formed by medium spiny projection neurons that express the Drd1 dopamine receptor (D1-MSNs). We …
Andrea Lee Frump · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $706,423 — PROJECT SUMMARY This proposal builds on the scientific premise that right ventricular (RV) maladaptive remodeling is a major contributor to RV failure and mortality in pulmonary hypertension (PH). Despite its importance, no RV-directed therapies exist. The goal of this proposal is to is to identify …
Emmie De Wit · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $56,623 — In any given year, lower respiratory tract infections are the leading cause of infectious disease deaths worldwide, and the fifth most important cause of death overall. Respiratory viruses keep emerging at a steady pace (e.g. MERS-CoV, enterovirus D68, avian influenza viruses), adding to the burden …
Emmie De Wit · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $1,400,690 — In any given year, lower respiratory tract infections are the leading cause of infectious disease deaths worldwide, and the fifth most important cause of death overall. Respiratory viruses keep emerging at a steady pace (e.g. MERS-CoV, enterovirus D68, avian influenza viruses), adding to the burden …
Edward Lakatta · NATIONAL INSTITUTE ON AGING · 2022 · $307,915 — Some projects that require expertise in microRNAs and, specifically, in miR-200 family and miR-34a, have been initiated. It has been shown that miR-200 family members (co-transcribed miR-200c, -141; co-transcribed miR-200b, -200a, -429) and miR-34a increase in response to oxidative stress suggesting…
Pedro A Piedra · BAYLOR COLLEGE OF MEDICINE · 2022 · $348,710 — PROJECT SUMMARY – Project 2 Respiratory syncytial virus (RSV) is a major global respiratory pathogen. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has resulted in an unprecedented crisis. Respiratory virus infections are often accompanied by gastrointestinal (GI) symptom…
Tara F Carr · UNIVERSITY OF ARIZONA · 2022 · $252,874 — The overall goal of this Asthma and Allergic Diseases Cooperative Research Center (AADCRC) proposal is to elucidate the mechanisms by which the innate immune system affords protection against viral-induced exacerbations in asthma. In the renewal of our AADCRC program, we will continue to focus on th…
Adolfo Garcia-Sastre · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $395,967 — PROJECT 2: ABSTRACT Project 2 is based on evidence that lung cancer patients have higher susceptibility to SARS-CoV-2 infection and increased risk of severe disease and mortality. This increased vulnerability is likely due to a combination of factors, including immune-suppressing effects of the canc…