NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Kari C. Nadeau · STANFORD UNIVERSITY · 2021 · $229,449 — SUMMARY The 2019 coronavirus disease (COVID-19) caused by the novel coronavirus 2 (SARS-CoV-2) has infected more than 16 million people worldwide and claimed the life of more than 650,000 persons worldwide within the past seven months. Several patient subgroups are at greater risk of more severe COV…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Kyeong-Ok Chang · KANSAS STATE UNIVERSITY · 2021 · $774,037 — PROJECT SUMMARY Human coronaviruses generally cause the common cold, a mild upper respiratory illness, however, global outbreaks of new human coronavirus infections with severe respiratory disease have periodically emerged from animals. These include Severe Acute Respiratory coronavirus (SARS-CoV), …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Blake Marie Hauser · HARVARD MEDICAL SCHOOL · 2021 · $37,980 — Project Summary/Abstract Since the emergence of the novel severe acute respiratory syndrome virus 2 (SARS-CoV-2) coronavirus, the need for better frameworks to rapidly develop vaccines in response to emerging viral threats, including other coronaviruses of potential pandemic concern, is clear. One a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Monica Kraft · UNIVERSITY OF ARIZONA · 2021 · $1,433,547 — In this AADCRC program renewal, we will focus on three critical and understudied innate immune factors and how they impact viral infections in asthma: the anionic phospholipids of surfactant (palmitoyl- oleoyl-phosphatidylglycerol, POPG, and phosphatidylinositol, PI), Toll interacting protein (Tolli…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Ralph S Baric · WASHINGTON UNIVERSITY · 2021 · $1,206,220 — Project Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that was first isolated in Wuhan China in December, 2019. SARS-CoV-2 is the cause of coronavirus disease 2019 (COVID-19), which is now a pandemic and has caused more than 1.3 mi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Meher R Juttukonda · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $462,000 — Abstract. It has become increasingly clear that the cerebrovascular system is under assault in many individuals infected with COVID-19. In recent studies, patients with hypertension were found at a two-fold increased risk of dying from COVID-19 infection, and 100% of infected patients who received a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
JOHN P COOKE · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $721,633 — ABSTRACT Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered Vein-Chip Challenge: Increasing evidence shows that SARS-CoV-2, which is the novel coronavirus that causes COVID- 19, is able to trigger the formation of blood clots within the veins of patien…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Elizabeth Gray · UNIVERSITY OF HOUSTON · 2021 · $28,747 — Abstract The increasing world-wide prevalence of obesity is a worrying public health problem and crisis. Coexistence of obesity, hypertension and diabetes significantly increases the risk of kidney dysfunction. In obesity, concentrations of angiotensin II (Ang II) increase, while those of Ang-(1-7) …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2021 — With prevalence higher than 33% in United States, hypertension is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. According to the Veterans’ Affairs (VA) Office of Research & Developmen…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Prasant Mohapatra · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $1,459,457 — Revised Abstract: The COVID-19 pandemic constitutes a significant challenge to health care systems in the United States and abroad. A systemic compromise of the organism following SARS-CoV-2 infection has emerged as an important factor associated with COVID-19 severity, disproportionally affecting o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Pamela Susan Douglas · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $1,210,912 — Project Summary In response to NOT-HL-20-757, Notice of Special Interest (NOSI): Availability of Administrative Supplements and revision Supplements on Coronavirus Disease 2019 (COVID-19), and PA-18-591 Administrative Supplements for existing NIH Grants and Cooperative Agreements, the enclosed admin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Heather Hickman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $260,347 — The emergence of SARS-CoV-2 in human populations in 2019 has resulted in a global pandemic with staggering morbidity and mortality. In humans, coronavirus-induced disease 2019 (COVID-19) is characterized by decreased lung function and increased pro-inflammatory cytokine production. As the immune m…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Giovanna Tosato · DIVISION OF CLINICAL SCIENCES - NCI · 2021 · $855,728 — We have focused on 4 related areas. 1) Our previous studies have identified a critical role of Delta4 (Dll4), an endothelial-specific membrane-bound ligand for Notch1 and Notch4, as a regulator of endothelial cell function. Dll4 is selectively expressed in the developing endothelium and is required …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Liang Cao · DIVISION OF BASIC SCIENCES - NCI · 2021 · $1,530,925 — Related to the specific goals above, we conducted various studies to support biomarker driven early-stage drug development: 1. Application of new or novel biomarkers in early stage trials of highly unique therapeutic agents. A) We supported marker investigation of Dr. Andrea Apolo by investigating t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Mark Knepper · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $142,521 — ---- The COVID-19 epidemic has resulted in disruption of normal laboratory activities in the Knepper lab, causing a shift of effort to computational and bioinformatic projects to maintain productivity by laboratory members. Some of this effort is focused on COVID-19 itself, leveraging our expertise …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Abraam M. Yakoub · UNIVERSITY OF NORTH DAKOTA · 2021 · $253,705 — Summary Coronavirus Disease of 2019 (COVID-19) is a US and global public health crisis. It has led to the deaths of hundreds of thousands in the US and worldwide. COVID-19 is caused by a novel beta-coronavirus (CoV) known as Severe Acute Respiratory Syndrome (SARS)-CoV-2, which was reported to cause…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Pedro A Piedra · BAYLOR COLLEGE OF MEDICINE · 2021 · $352,938 — PROJECT SUMMARY – Project 2 Respiratory syncytial virus (RSV) is a major global respiratory pathogen. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has resulted in an unprecedented crisis. Respiratory virus infections are often accompanied by gastrointestinal (GI) symptom…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Vincent C Bond · MOREHOUSE SCHOOL OF MEDICINE · 2021 · $177,500 — Abstract: Diversity in the rates of progression and mortality of COVID-19 disease within infected African American (AAs) subgroups are clearly not just a function of the underlying health conditions that increase the rate of mortality for COVID -19 patients, such as hypertension, obesity and diabete…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Craig Andrew Miller · OKLAHOMA STATE UNIVERSITY STILLWATER · 2021 · $240,655 — The overall objective of this project is to validate mechanisms of viral fitness and immunopathogenesis during SARS-CoV-2 infection in domestic cats to establish baselines for downstream translational studies. Major goals (specific aims) for this project are as follows: Aim 1. Evaluate in vivo in…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
LINDA CHANG · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $424,875 — Project Summary This R21 Exploratory/Developmental Research Grant is written in response to PAR-20-177: Emergency Awards: Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19). SARS-CoV2 is the virus that causes COVID-19, and is k…