Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
di s xia · DIVISION OF BASIC SCIENCES - NCI · 2020 · $370,494 — Progress (1) Lead identification. Based on the well-established principle that the S proteins carry out all of the cell entry functions of CoVs, the CoV S spike were incorporated onto a replication defective HIV core, resulting pseudovirions with SARS-CoV-2 S protein expressed on the surface of vira…
Thomas Redmond · NATIONAL EYE INSTITUTE · 2020 · $1,453,666 — We are studying RPE-specific mechanisms, at both the regulatory and functional levels, and have been studying the function and regulation of RPE65, the key retinol isomerase enzyme of the visual cycle. Current work is focused on establishing the molecular mechanism of RPE65 catalysis, as well as its…
John Mascola · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $4,122,850 — The Virology Core has collaborated with other intramural NIAID labs to develop a MERS-CoV Spike protein subunit vaccine. A vaccine of adjuvanted MERS-CoV Spike protein subunit vaccine confers complete protection from MERS-CoV disease in alpaca and results in reduced and delayed viral shedding in the…
Robert E London · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $1,046,440 — Independent Project: Folate-dependent enzymes play a central role in single carbon metabolism and in nucleotide biosynthesis; its perturbation can be mutagenic and ultimately lethal. More generally, dysregulation of folate metabolism appears to be broadly linked to deficiencies in genome methylation…
Heather Kalish · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2020 · $650,000 — Sub-project #1 Multiplex ELISA analysis of cell secretions Multiplex ELISA improves upon the traditional ELISA format. Rather than detecting a single antigen in a single sample, multiplex technology allows for the detection of up to 16 antigens from a single sample. This reduces the overall time …
Peter D Kwong · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $1,833,636 — Based on our understanding of spike- or envelope-based mechanisms of humoral evasion, we are working to design envelope-based immunogens with these evading mechanisms disabled. Such modified immunogens with weakened defenses may elicit more broadly neutralizing antibodies. We have also devised prote…
JOHN ALTMAN · EMORY UNIVERSITY · 2020 · $599,404 — The NIH Tetramer Core Facility (TCF) distributes high quality reagents for detection of innate T cell and classical CD4 and CD8 T cell populations. This Facility also conducts R&D to produce new reagents and improve existing tetramer technologies. The TCF is producing MHC class I and class II tet…
Michael S Kay · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $449,404 — SARS-CoV-2, a novel coronavirus, is the causative agent of the current worldwide pandemic that has already led to over 2 million infections, 125,000 deaths, and severe economic impact. Currently no preventatives, treatments, or vaccines are available, and care is solely supportive. Additionally, the…
Taia Wang · STANFORD UNIVERSITY · 2020 · $931,365 — PROJECT 1: SUMMARY As established through decades of research in protective immunity against infectious pathogens, achieving durable immunity against SARS-CoV-2 will require specific functional properties of antibodies, B cells and T cells that need to be defined through detailed repertoire studies.…
Sallie R. Permar · DUKE UNIVERSITY · 2020 · $137,491 — ABSTRACT The emergence of the highly-transmissible novel coronavirus SARS-CoV-2 has led to a global pandemic of severe respiratory disease. While elderly individuals and adults with co-morbidities are high risk populations, coronavirus disease (COVID-19) can occur in individuals across all age group…
Florian Krammer · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $1,396,346 — PROJECT 1: ABSTRACT Current information indicates that, in persons without cancer, natural infection with SARS-CoV-2 as well as vaccination with COVID-19 vaccine candidates induce antibody responses to the spike protein of the virus which should be protective against future infection. Lung cancer pa…
ARPANA AGRAWAL · WASHINGTON UNIVERSITY · 2020 · $645,723 — A recent CDC report observed that heroin use has increased in men and women across the U.S., including most age groups and all income levels. The current heroin epidemic follows an ongoing prescription opioid misuse epidemic that has helped drive the spike in heroin use. Research to improve understa…
Darrin H Brager · UNIVERSITY OF TEXAS AT AUSTIN · 2020 · $441,246 — Abstract The hippocampus is involved in several learning and memory tasks and patients with Fragile X syndrome (FXS) display a variety of phenotypes related to hippocampal dysfunction. Voltage-gated ion channels are critical to information processing by hippocampal circuits. H-channels (Ih) influenc…
Lanying Du · NEW YORK BLOOD CENTER · 2020 · $526,550 — DESCRIPTION (provided by applicant): The recurrent outbreak of deadly infectious diseases worldwide heightens the urgency to develop new and improved vaccines to combat their spread. Unfortunately, many of the current vaccines, or those in development, induce suboptimal immune responses and require …
Amber J Zimmerman · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $37,556 — Project Summary Schizophrenia (SCZ) and Bipolar Disorder (BD) are multifactorial psychiatric disorders that are often marked by impaired functioning of the prefrontal cortex (PFC) that leads to behavioral deficits including impairments in executive functioning, such as cognitive flexibility. SCZ and…
VINEET D MENACHERY · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $497,886 — Abstract The coronavirus (CoV) spike protein is a key viral determinant responsible for receptor binding and fusion/entry. The spike protein has also been predicted to be the major factor driving cross-species transmission, allowing the emergence of epidemic strains like SARS- and MERS-CoV. In the f…
Robert N Kirchdoerfer · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $248,995 — SUMMARY Coronaviruses are sporadically emerging viruses responsible for SARS and MERS disease outbreaks. There are currently no direct treatments for these viruses, nor is there a vaccine which induces broad protection from infection. However, several stages in the virus life cycle are promising ta…
Samuel Matthew Young · UNIVERSITY OF IOWA · 2020 · $385,434 — The diversity of information encoding by neuronal circuits is regulated by the magnitude and location of Ca2+ entry though voltage-gated Ca2+ channels (CaV). In the mammalian central nervous system, the CaV2.1 channel is the critical subtype for CNS function since it is the most efficient CaV2 subty…
Kelly Keisen Lee · UNIVERSITY OF WASHINGTON · 2020 · $396,951 — Enveloped viruses use specialized protein machinery to fuse their membrane with the membrane of host cells and deliver their genetic material for replication. In influenza virus, the trimeric hemagglutinin (HA) glycoprotein spike is responsible for host cell attachment and membrane fusion. The seque…
Kazutoshi Nakazawa · SOUTHERN RESEARCH INSTITUTE · 2020 · $793,787 — Abstract Abnormal neuronal synchrony at gamma range, often observed in schizophrenia, may be associated with cognitive deficits. Although evidence suggests that cortical fast-spiking interneurons targeting pyramidal cells may be involved in neuronal synchrony, cellular basis of abnormal neuronal syn…