Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Nadejda Mincheva Tsankova · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $339,000 — SUMMARY Coronavirus disease 2019 (COVID19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a global pandemic, causing overwhelming morbidity and mortality. While the main manifestations of COVID19 relate to problems with respiration, emerging studies recognize…
Shyam Biswal · JOHNS HOPKINS UNIVERSITY · 2020 · $450,313 — It is estimated that while the majority of SARS-CoV2 infections in the ongoing coronavirus disease-2019 (COVID-19) pandemic are asymptomatic or have mild symptoms, hospitalizations and mortality largely occurs in patients with co-morbid conditions such as obesity, diabetes and COPD. Our understandin…
Thomas Hope · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $786,043 — Summary: The current pandemic of COVID-19 has rapidly spread around the world infecting millions and killing more than 200,000 people in just months. The first wave of the pandemic is currently peaking in the United States causing almost 60,000 deaths in the past 6 weeks. This highly contagious viru…
Heather Hickman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $258,827 — The emergence of SARS-CoV-2 in human populations in 2019 has resulted in a global pandemic with staggering morbidity and mortality. In humans, coronavirus-induced disease 2019 (COVID-19) is characterized by decreased lung function and increased pro-inflammatory cytokine production. As the immune m…
ROBERT M LAVKER · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $410,000 — PROJECT SUMMARY/ABSTRACT The anterior surface of the eye functions as a barrier to the external environment and protects the delicate underlying structures from injury, in part, through the elaboration of the limbal and corneal epithelia. It is well- accepted that the limbal epithelium is the site o…
Elizabeth Gray · UNIVERSITY OF HOUSTON · 2019 · $34,186 — Abstract The increasing world-wide prevalence of obesity is a worrying public health problem and crisis. Coexistence of obesity, hypertension and diabetes significantly increases the risk of kidney dysfunction. In obesity, concentrations of angiotensin II (Ang II) increase, while those of Ang-(1-7) …
Michael Edwin Boulton · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2019 · $403,279 — This proposal examines the hypothesis that diabetes results in a pathological change in the communication between the bone marrow (BM) and gut leading to dysfunction in both compartments. Angiotensin converting enzyme 2 (ACE2) converts angiotensin II (ANG II) to angiotensin 1-7(Ang 1-7) which, by vi…
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2019 — With prevalence higher than 33% in United States, hypertension is a major risk factor contributing to cardiovascular diseases (CVD) and global mortality, hence remaining an increasingly important medical and public health issue. According to the Veterans’ Affairs (VA) Office of Research & Developmen…
Irving H Zucker · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2019 · $437,136 — PROJECT SUMMARY/ABSTRACT Chronic heart failure (CHF) affects a growing number of Americans. This disease is one of the leading causes of death and disability in the developed world. In order to develop new therapies for this disorder a comprehensive understanding of the pathogenesis and mechanisms b…
Eric Gerald Krause · UNIVERSITY OF FLORIDA · 2019 · $381,250 — Project Summary Stressful life events contribute to the etiology of anxiety and hypertension and increase the risk for cardiovascular disease, which is the leading cause of death in the U.S. Despite a myriad of research, nearly one-third of patients with anxiety and/or hypertension are resistant to …
Jason Davin Gardner · LSU HEALTH SCIENCES CENTER · 2019 · $413,160 — Project Summary Nicotine is the addictive component of tobacco-derived products. Through binding to a family of nicotinic acetylcholine receptors (nAChRs), nicotine influences a diverse range of cellular mechanisms involved in homeostasis and disease. Although cigarette smoking is a major risk fact…
Yagna Jarajapu · NORTH DAKOTA STATE UNIVERSITY · 2019 · $50,000 — Healthy cerebral vasculature and adequate blood flow determine overall brain health. Vascular cognitive impairment and dementia (VCID) has now been recognized as a clinical condition with cerebrovascular dysfunction as the underlying pathological mechanism. Aging and diabetes are independent risk fa…
Kathryn Marie Jones · BAYLOR COLLEGE OF MEDICINE · 2024 · $781,984 — Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection Abstract: Chagas disease, caused by infection with the vector borne intracellular protozoal parasite Trypanosoma cruzi, affects approximately 6.5 million people worldwide. Chronic infection with T. cruz…
Yanmin Zhu · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $89,500 — Congenital cytomegalovirus (cCMV) infection is the most common congenital infection in the US, affecting one in every 200 infants each year. Approximately 10% of newborns impacted by cCMV have symptoms at birth, such as small size for gestational age, jaundice, petechiae/purpira, and hepatosplenomeg…
ROBERTO DOCAMPO · UNIVERSITY OF GEORGIA · 2024 · $226,500 — Abstract Cardiomyopathy is the most frequent clinical manifestation of Chagas disease. The pathogenesis of the heart disease is attributed to the persistence of T. cruzi leading to chronic inflammation, fibrosis, cardiac hypertrophy and heart failure. Fibrosis results from excessive accumulation of …
Maria Pilar Aoki · NATIONAL RESEARCH COUNCIL OF ARGENTINA · 2024 · $130,912 — Project Summary Chagas disease, a major public health problem in Latin America, is caused by the infection with the protozoan parasite Trypanosoma (T.) cruzi and has been spread to non-endemic regions by migratory movements. Chagas cardiomyopathy represents the most severe complication of chronic Ch…
Matthew R Vogt · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $611,746 — Project Summary Manifestations of enterovirus infections are variable, with several severe illnesses such as meningitis, acute flaccid myelitis (AFM), myocarditis, and neonatal sepsis. Poliovirus vaccines are near perfect at preventing severe illness by generating strong, circulating antibody respon…
Benjamin L King · UNIVERSITY OF MAINE ORONO · 2024 · $270,911 — PROJECT SUMMARY / ABSTRACT Skeletal muscle myopathy has been reported following infection by influenza virus. In Influenza-Associated Myopathy (IAM), a systemic influenza infection can result in acute skeletal muscle damage that ranges from non- specific degeneration to extensive necrosis. IAM is as…
Umesh C Sharma · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $398,750 — Immunomodulation of Galectin-3 to Prevent Radiation-Induced Myocardial Fibrogenesis This application addresses the scientific goals of FOA-PA-19-112. More than half of life-threatening thoracic cancers are treated with repeated doses of ionizing radiation. Unfortunately, the pro-inflammatory and pr…
Mary Weber · UNIVERSITY OF IOWA · 2024 · $241,644 — Project Summary Orientia tsutsugamushi (O.t.) is the etiological agent of scrub typhus, a devastating disease with a high mortality rate that is transmitted by the bite of certain trombiculid mites or “chiggers”. Over one million individuals are infected annually, however, these statistics may be a …