Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jun Wang · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $755,280 — Project Summary Non-polio enteroviruses (NPEVs) are etiological agents for several human diseases including respiratory infections, hand-foot-and-mouth disease (HFMD), aseptic meningitis, encephalitis, neonatal sepsis, myocarditis, conjunctivitis, and acute flaccid paralysis. Among the more than 10…
Raul Andino · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $147,486 — Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mouth disease. In some cases, the infection is life- threateni…
Matthew R Vogt · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $5,421,688 — PROJECT SUMMARY - RP2 Picornaviruses are an ever-present threat to human health, causing myriad diseases ranging from mild (common colds, hand, foot, and mouth disease) to more severe (meningitis, acute flaccid myelitis, myocarditis, and neonatal sepsis). Fortunately, one of the most successful vacc…
Matthew R Vogt · UNIV OF NORTH CAROLINA CHAPEL HILL · 2023 · $651,621 — Project Summary Manifestations of enterovirus infections are variable, with several severe illnesses such as meningitis, acute flaccid myelitis (AFM), myocarditis, and neonatal sepsis. Poliovirus vaccines are near perfect at preventing severe illness by generating strong, circulating antibody respon…
Jay Reddy · UNIVERSITY OF NEBRASKA LINCOLN · 2023 · $180,736 — PROJECT SUMMARY/ABSTRACT Enteroviruses, such as group B Coxsackieviruses, are common suspects in myocarditis and pancreatitis. However, no vaccines are currently available for these viruses, in part because multiple serotypes of Coxsackieviruses can induce similar diseases. Thus, exploration of alte…
Raul Andino · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $98,324 — Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mouth disease. In some cases, the infection is life- threateni…
Michael Ombrello · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2023 · $974,635 — In the current reporting period, we have continued to employ genetic and genomic approaches to discover causes of or risk factors for Stills disease/systemic juvenile idiopathic arthritis (sJIA). We have continued working on an Immunochip association study of 889 children with sJIA and >16,000 con…
William T Jackson · UNIVERSITY OF MARYLAND BALTIMORE · 2023 · $386,250 — Enteroviruses are among the most severe causes of human disease, and recent outbreaks of emerging enteroviruses such as types D68 and 71 have highlighted the need to understand more about these pathogens. Our comparative studies of poliovirus (PV), coxsackievirus B3, and now EV-D68 have shown many c…
Maria Pilar Aoki · NATIONAL RESEARCH COUNCIL OF ARGENTINA · 2023 · $130,742 — Project Summary Chagas disease, a major public health problem in Latin America, is caused by the infection with the protozoan parasite Trypanosoma (T.) cruzi and has been spread to non-endemic regions by migratory movements. Chagas cardiomyopathy represents the most severe complication of chronic Ch…
Benjamin L King · UNIVERSITY OF MAINE ORONO · 2023 · $261,916 — PROJECT SUMMARY / ABSTRACT Skeletal muscle myopathy has been reported following infection by influenza virus. In Influenza-Associated Myopathy (IAM), a systemic influenza infection can result in acute skeletal muscle damage that ranges from non- specific degeneration to extensive necrosis. IAM is as…
Kathryn Marie Jones · BAYLOR COLLEGE OF MEDICINE · 2023 · $785,194 — Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection Abstract: Chagas disease, caused by infection with the vector borne intracellular protozoal parasite Trypanosoma cruzi, affects approximately 6.5 million people worldwide. Chronic infection with T. cruz…
Umesh C Sharma · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2023 · $398,750 — Immunomodulation of Galectin-3 to Prevent Radiation-Induced Myocardial Fibrogenesis This application addresses the scientific goals of FOA-PA-19-112. More than half of life-threatening thoracic cancers are treated with repeated doses of ionizing radiation. Unfortunately, the pro-inflammatory and pr…
ROBERTO DOCAMPO · UNIVERSITY OF GEORGIA · 2023 · $188,750 — Abstract Cardiomyopathy is the most frequent clinical manifestation of Chagas disease. The pathogenesis of the heart disease is attributed to the persistence of T. cruzi leading to chronic inflammation, fibrosis, cardiac hypertrophy and heart failure. Fibrosis results from excessive accumulation of …
Raul Andino · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $848,303 — Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mouth disease. In some cases, the infection is life- threateni…
Raul Andino · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $868,678 — Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mouth disease. In some cases, the infection is life- threateni…
Jay Reddy · UNIVERSITY OF NEBRASKA LINCOLN · 2022 · $217,570 — PROJECT SUMMARY/ABSTRACT Enteroviruses, such as group B Coxsackieviruses, are common suspects in myocarditis and pancreatitis. However, no vaccines are currently available for these viruses, in part because multiple serotypes of Coxsackieviruses can induce similar diseases. Thus, exploration of alte…
Kristina M. Adams Waldorf · UNIVERSITY OF WASHINGTON · 2022 · $849,396 — Project Summary Pregnant women are highly vulnerable to influenza A virus (IAV) and are at increased risk for maternal death, preterm birth and stillbirth. Universal influenza vaccines (UFV) are thought to be possible if conserved regions of influenza virus are targeted and appropriate immune respon…
Kathryn Marie Jones · BAYLOR COLLEGE OF MEDICINE · 2022 · $783,532 — Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection Abstract: Chagas disease, caused by infection with the vector borne intracellular protozoal parasite Trypanosoma cruzi, affects approximately 6.5 million people worldwide. Chronic infection with T. cruz…
William T Jackson · UNIVERSITY OF MARYLAND BALTIMORE · 2022 · $386,250 — Enteroviruses are among the most severe causes of human disease, and recent outbreaks of emerging enteroviruses such as types D68 and 71 have highlighted the need to understand more about these pathogens. Our comparative studies of poliovirus (PV), coxsackievirus B3, and now EV-D68 have shown many c…
Matthew R Vogt · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $653,847 — Project Summary Manifestations of enterovirus infections are variable, with several severe illnesses such as meningitis, acute flaccid myelitis (AFM), myocarditis, and neonatal sepsis. Poliovirus vaccines are near perfect at preventing severe illness by generating strong, circulating antibody respon…