Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
DAVID BAKER · UNIVERSITY OF WASHINGTON · 2021 · $723,634 — PROJECT SUMMARY One of the most pressing public health priorities for the COVID-19 pandemic is the development of an effective and inexpensive therapeutic. The long-term goal of this proposal is to develop such COVID-19 treatments, as well as the methods needed to rapidly create such molecules as so…
JUAN M SAAVEDRA · GEORGETOWN UNIVERSITY · 2021 · $661,469 — SARS-CoV-2, the virus underlying the current COVID-19 pandemic, not only affects peripheral tissues, it also targets the brain causing microvascular lesions, microhemorrhages and neurological manifestations. The internalization of SARS-CoV-2 is initiated by the binding of the virus spike protein to …
Bryan J Venters · EPICYPHER, INC. · 2021 · $306,500 — PROJECT SUMMARY Single cell (SC) epigenomics is a rapidly emerging field, driven by recent technology advances and the diverse roles that epigenetic features play in controlling gene activation. Histone post-translational modifications (PTMs) represent some of the most relevant and widely studied e…
Kristina L Bailey · OMAHA VA MEDICAL CENTER · 2021 — COVID-19 is now a global pandemic requiring a rapid and concerted response from the scientific and medical community. Based upon recent epidemiology derived only months earlier from the earliest affected countries, the pathogenesis of the SARS-CoV-2 virus and clinical outcomes from COVID-19 are far …
Bryce C Chackerian · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $511,894 — Project Summary / Abstract This proposal describes the framework of an R01 grant by Dr. Daniel Lingwood, an Assistant Professor at Harvard Medical School and faculty member of the Ragon Institute of MGH, MIT and Harvard, and Dr. Bryce Chackerian, an Associate Professor in the Department of Molecular…
Wah Chiu · STANFORD UNIVERSITY · 2021 · $196,016 — Herpesviruses are pathogens of medical and economic significance that cause a range of diseases in humans and animals. Varicella-zoster virus (VZV) is an important human alpha herpesvirus that causes varicella and zoster after reactivation from latency in sensory ganglia. The morphogenesis of varice…
Carey Lynn Shive · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2021 — The global pandemic of SARS-CoV-2 is placing urgent demands on health care workers and researchers. Between April 3rd and May 1st global cases of COVID19 nearly tripled from approximately 1 million to over 3 million. With the possibility of a reemergence of SARS-CoV-2 in the fall, rapid specific ant…
Susan Daniel · CORNELL UNIVERSITY · 2021 · $439,686 — Project Summary / Abstract Enveloped viruses access their host cells by binding to receptors on the plasma membrane and then undergoing fusion with the host membrane. Both binding and fusion are mediated by a specific viral “spike” protein that is typically primed for fusion activation by proteolyti…
Patricia Bea Keady · AEROSOL DEVICES, INC. · 2021 · $262,802 — As the current COVID-19 pandemic has demonstrated, aerosolized pathogens such as SARS-CoV-2 can spread explosively if not quickly detected. Early detection of these airborne pathogens can help control out- breaks, particularly within vulnerable populations in densely populated spaces including assis…
Jianfa Bai · KANSAS STATE UNIVERSITY · 2021 · $69,358 — Project Summary: SARS-CoV-2 is a major human respiratory pathogen that can cause COVID-19, a disease with symptoms similar to those caused by Influenza A (Flu A) and Influenza B (Flu B) viruses. A few major SARS-CoV-2 variants of concern (VOC) have been identified and associated with increased trans…
Radislav A Potyrailo · GENERAL ELECTRIC GLOBAL RESEARCH CTR · 2021 · $581,785 — PROJECT SUMMARY/ABSTRACT Available tools for detection of SARS-CoV-2 virus require extensive sample preparation and/or expensive lab- based equipment to obtain accurate results. The objective in this proposal is to build a touch-screen sensor array to directly capture, detect, and identify model SAR…
Thomas M McIntyre · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $572,341 — Hypertension, for unknown reasons, is a primary co-morbidity risk factor for poor COVID-19 outcomes. SARS- Cov-2 breaches the lung blood-air barrier to spread among organs inducing endothelial cell dysfunction and multi-organ thromboembolism. ACE2 is the high affinity receptor for SARS-Cov-2 with TM…
TOMAS KIRCHHAUSEN · WASHINGTON UNIVERSITY · 2021 · $766,721 — The long term goal of this study is to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), enters cells and how to block that process through the use of therapeutics. Like other enveloped viruses, SARS-CoV-2 cell entry…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2021 · $194,118 — Administrative Supplement for Equipment - GM122917 Margaret A. Titus, PI Abstract of Parent Project Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and i…
Erica Ollmann Saphire · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2021 · $1,903,653 — Abstract SARS-CoV-2 rapidly emerged and spread throughout the globe to infect millions of people. The SARS-CoV-2 spike protein is the primary target of the immune response and thus most vaccine development efforts used the spike protein as an immunogen to elicit protective antibodies. However, as SA…
Michael-Christopher Keogh · EPICYPHER, INC. · 2021 · $1,024,792 — PROJECT SUMMARY Alterations in histone post-translational modifications (PTMs) are associated with diverse human pathologies. The ability to quantitatively assess these PTMs in healthy and diseased cells is essential to accelerate the development of drugs or diagnostics targeting epigenetic regulat…
Rebecca Penrose Wilkes · PURDUE UNIVERSITY · 2021 · $77,500 — Project Summary SARS-CoV-2, the viral cause of COVID-19, has infected at least 94 pet cats in the United States, based on confirmed cases by the USDA. Many infections in cats are asymptomatic, and there are only a few ongoing surveillance studies in companion animals, so the number of cases in cats …
Savita Pahwa · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2021 · $153,500 — This Competitive Revision application for 2019 Novel Coronavirus research is related to the current grant Immune Dysfunction in HIV+ Opioid Users (DA051202) which is investigating influenza vaccine responses in people with HIV (PWH) who have opioid use disorder (OUD). The premise for the funded gran…
Luis J Montaner · WISTAR INSTITUTE · 2021 · $156,933 — SUMMARY The administration of effective anti- SARS-CoV-2 vaccines capable of eliciting a protective immune response in a large proportion of the population is a major public heath priority in combating Coronavirus disease 2019 (COVID-19). Our studies indicates that the functionality of soluble antib…
SEBLE G KASSAYE · GEORGETOWN UNIVERSITY · 2021 · $35,088 — ABSTRACT MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV- infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, how…