Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Thomas Miller Gallagher · UNIVERSITY OF IOWA · 2021 · $266,291 — PROJECT SUMMARY The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic virus that can cause fatal disease in patients with underlying comorbidities. Further recognition of this respiratory syndrome and prevention strategies will require a small animal infection model as well as an…
ALLAN I LEVEY · EMORY UNIVERSITY · 2021 · $848,836 — The Open Drug Discovery Center for AD (Open-AD) Structural Biology core aims to provide Target Enabling Packages (TEPs): a combination of experimental tools and knowledge that will allow researchers to investigate the biology of potential drug targets and to test therapeutic hypotheses. The TEPs wil…
Kevin Wiehe · DUKE UNIVERSITY · 2021 · $4,217,384 — Abstract – Project 2 Animal betacoronaviruses (betaCoVs), such as those that gave rise to SARS-CoV-1, MERS, and now SARS- CoV-2, represent a significant, continuous threat to human health. Vaccines can provide pre-existing immunity to future zoonotic coronaviruses. A major limitation of the current …
Erica Ollmann Saphire · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $2,628,877 — Project 3 Summary Coronaviruses will likely remain a persistent threat to human health. However, whether the next significant disease outbreak will be caused by a known coronavirus, another novel coronavirus, or continued surges from variant(s) of SARS-CoV-2 is unknown. The goal of this project is t…
Duane R. Wesemann · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $3,169,124 — PROJECT 1 SUMMARY Global establishment of Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is a continued human threat. While successful vaccine programs are well underway, genetic drift and immune escape have already begun to subvert immunity. In addition, related zoonotic coronaviruses…
Kristina De Paris · WEILL MEDICAL COLL OF CORNELL UNIV · 2021 · $46,196 — ABSTRACT – Overall Nearly 600,000 new HIV infections occur yearly in adolescents/young adults (ages 15-24 years), the only population in which HIV infections continue to rise. The end of the HIV/AIDS epidemic will be achievable only when an effective vaccine regimen can elicit long-term protective i…
JOHN ALTMAN · EMORY UNIVERSITY · 2021 · $856,666 — The NIH Tetramer Core Facility (TCF) distributes high quality reagents for detection of innate T cell and classical CD4 and CD8 T cell populations. This Facility also conducts R&D to produce new reagents and improve existing tetramer technologies. The TCF is producing MHC class I and class II tetram…
JOHN ALTMAN · EMORY UNIVERSITY · 2021 · $200,000 — The NIH Tetramer Core Facility (TCF) distributes high quality reagents for detection of innate T cell and classical CD4 and CD8 T cell populations. This Facility also conducts R&D to produce new reagents and improve existing tetramer technologies. The TCF is producing MHC class I and class II tetram…
Kui Kiu Chan · CYRUS BIOTECHNOLOGY, INC. · 2021 · $160,584 — ABSTRACT The spike protein (S) of SARS coronavirus 2, the pathogen responsible for COVID-19, binds angiotensin- converting enzyme 2 (ACE2) as an entry receptor, triggering conformational changes in S that drive fusion of the viral envelope and host cell membrane. Infection is inhibited by neutraliz…
GARY B RUVKUN · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $344,400 — Project Summary/Abstract: C. elegans surveils the mitochondrion for deficits and couples to an endocrine system of detoxification, innate immunity, and longevity control. This coupling of immunity and detoxification pathways to lifespan regulation has been observed in mice as well. Our analysis of i…
SUBHRA MOHAPATRA · JAMES A. HALEY VA MEDICAL CENTER · 2021 — COVID-19 super pandemic is still suffering from the lack of a vaccine or infection control measures and the lack of any treatments against this new virus. One of the unique features of SARS-CoV-2 is that it has an R0=2.2 (the ability of an infected patient to spread the disease) vs R0=1 for SARS-CoV…
TIMOTHY A HAYSTEAD · EYDIS BIO, INC. · 2021 · $309,288 — PROJECT SUMMARY/ABSTRACT The recent pandemic of novel coronavirus, COVID-19, has had a devastating effect on the health and well-being of individuals across the globe, including over 3.1 million confirmed infected so far, and a monumental impact on global healthcare systems and economies at large. I…
Carl W White · UNIVERSITY OF COLORADO DENVER · 2021 · $182,367 — PROJECT SUMMARY In the COVID-19 pandemic, >1.5 million Americans have become ill, and over 100,000 have died. So far, medically underserved populations are more than twice as likely to die or develop critical illness relative to their proportion in the population. Current and former smokers are also…
VINEET D MENACHERY · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $497,886 — Abstract The coronavirus (CoV) spike protein is a key viral determinant responsible for receptor binding and fusion/entry. The spike protein has also been predicted to be the major factor driving cross-species transmission, allowing the emergence of epidemic strains like SARS- and MERS-CoV. In the f…
MARK L DELL'ACQUA · UNIVERSITY OF COLORADO DENVER · 2021 · $595,402 — Plasticity in the hippocampus leads to persistent changes in synaptic structure and function that underlie learning and memory. Intracellular Ca2+ signaling pathways activated downstream of NMDA receptors (NMDAR) and L-type voltage-gated Ca2+ channels (LTCC) contribute to changes synaptic function t…
Mikhail G Kolonin · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2021 · $368,900 — White adipose tissue (WAT) is the main lipid reservoir that becomes dysfunctional in obesity. It is important to understand how breached lipid homeostasis leads to metabolic disease. Efficient long chain fatty acid (FA) and cholesterol trafficking depends on a transmembrane transporter protein CD36.…
MARK J SCHNITZER · STANFORD UNIVERSITY · 2021 · $875,437 — Abstract Groundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their genetic signatures. The dividends from this research will include sophisticated tools allowing selective genetic access to these cell-types, such as for imaging, optogenetic or tracing studi…
Robert G Lowery · BELLBROOK LABS, LLC · 2021 · $390,500 — Abstract SARS CoV-2 and related coronaviruses hijack host proteins to facilitate cell entry, replication and immune suppression. Targeting hijacked host proteins is an attractive strategy for development of broad-spectrum antiviral drugs because the same proteins are often targeted by multiple virus…
Lanying Du · GEORGIA STATE UNIVERSITY · 2021 · $766,055 — Summary A novel coronavirus (CoV), SARS-CoV-2, is causing global pandemics with growing numbers of daily cases and deaths. SARS-CoV-2 is closely related to SARS-CoV, which caused the 2002-2003 SARS epidemic, and less closely related to MERS-CoV, which causes a high mortality rate in infected patient…
URSZULA T IWANIEC · OREGON STATE UNIVERSITY · 2021 · $72,235 — PROJECT SUMMARY SARS-CoV-2, the viral cause of Coronavirus Disease 2019 (COVID-19), is a highly contagious coronavirus, which upon infection results in a non-uniform distribution of clinical response. SARS-CoV-2 infects the lung and other organs, including liver and immune system, with non-lung infe…