NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Peter B. Gilbert · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $18,322,345 — Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for implementation of the COVID-19 vaccine efficacy trial entitled “A Randomized, Double-blind, Placebo-controlled Phase 3 Study to Assess the Efficac…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
DARRICK Albert CARTER · PAI LIFE SCIENCES, INC. · 2021 · $243,000 — PROJECT SUMMARY Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in late 2019 causing Coronavirus Disease 2019 (COVID-19) and within months became a worldwide pandemic - as of the writing of this proposal, at least 82.5M people have been infected and more than 1.8M have died in a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Paras Patel · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2021 · $39,800 — PROJECT SUMMARY Understanding how different regions of the central nervous system (CNS) are affected by genetic insults is critical to advancing the study of CNS pathologies which present a major public health burden in the United States. The cerebellum and optic nerve are two such regions that are …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Anne Moscona · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $773,390 — No vaccines or treatments for SARS-CoV-2 are yet available. A simple prophylactic antiviral strategy would protect naïve individuals from infection now. In the future, when vaccines should be available, a prophylactic antiviral will be essential for individuals who do not mount a suitable immune res…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Michel C Nussenzweig · ROCKEFELLER UNIVERSITY · 2021 · $458,301 — The WHO and US authorities have declared a public health emergency over the recent outbreak of a new coronavirus (CoV) originating from Wuhan, China (nCoV-2019, recently renamed SARS-CoV-2 and responsible for causing the coronavirus disease termed COVID-2019). The discovery of human monoclonal antib…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Hongpeng Jia · JOHNS HOPKINS UNIVERSITY · 2021 · $202,068 — Summary of the Funded Parent Grant (1R21AI149321-01, 01/01/2020 - 12/31/2021) Pneumonia and associated inflammatory lung diseases (ILD) are a leading cause of death among children and elderly worldwide and a significant source of morbidity and mortality among hospitalized patients. Interestingly, th…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Dennis R. Burton · SCRIPPS RESEARCH INSTITUTE, THE · 2021 · $635,619 — Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded RNA viruses and are divided into Alphaand Beta-coronaviruses. CoVs infect mammals and birds and typically result in lower and/or upper respiratory tract disease. The spectrum of illness in humans caused by CoVs range from common co…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Ivan Zanoni · BOSTON CHILDREN'S HOSPITAL · 2021 · $777,874 — PROJECT SUMMARY Vaccines represent a highly effective public health measure to protect individuals from infectious diseases. Many vaccines work by inducing antigen-specific antibodies that neutralize the pathogen or its products and promote their clearance. Vaccines based on protein antigens usually…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Eric D Lazartigues · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · 2021 — The current COVID-19 pandemic is one of the most disruptive events in human history, caused by the SARS- CoV-2 virus, member of the coronavirus family that uses angiotensin converting enzyme 2 (ACE2), a transmembrane carboxypeptidase identified as a member of the renin-angiotensin system (RAS) as an…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Maria Kireeva · AFFINITY MOLECULES, LLC · 2021 · $297,193 — ABSTRACT RNA emerges as a promising therapeutic agent and is becoming an increasingly popular tool for delivery of genetic information to cultured cells and living organisms. Notably, mRNA is used as a basis for new vaccine development and personalized gene therapy and is replacing DNA vectors in a …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Margaret M Stratton · UNIVERSITY OF MASSACHUSETTS AMHERST · 2021 · $313,229 — PROJECT SUMMARY How does a memory outlast the lifetime of the molecule that encodes it? More than two decades ago, Francis Crick had the foresight to speculate that perhaps a multimeric protein could serve as a molecular memory by sharing its activation state with newly synthesized proteins through …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
LUKAS K TAMM · UNIVERSITY OF VIRGINIA · 2021 · $562,219 — PROJECT SUMMARY Membrane fusion, mediated by viral spike glycoproteins, is a key process in the infection cycle of all enveloped human and animal viruses. The overall goal of this project is to understand the molecular mechanisms of Ebola and human immunodeficiency virus entry by membrane fusion, by…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2021 · $531,000 — Project Summary Membrane fusion, mediated by HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], is the first critical step for the virus to enter host cells and establish infection. A mature Env spike contains three copies each of noncovalently-associated receptor-binding…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Oreola Donini · SOLIGENIX, INC. · 2021 · $636,664 — 7. Project Summary/Abstract The proposal requests funding to support manufacturing and immune characterization of a novel, emulsified adjuvant which is uniquely compatible with lyophilization strategies to enable thermostabilization of glycoprotein vaccines. The major objectives of the study are to …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
David Scott Wilson · JOHNS HOPKINS UNIVERSITY · 2021 · $204,688 — 1. ABSTRACT/SUMMARY Given that the site of entry of SARS-CoV-2 is the respiratory mucosa, an effective vaccine for SARS-CoV-2 should initiate both humoral and respiratory mucosal immune responses. Although an intranasal subunit vaccine would be an ideal platform for SARS-CoV-2, transport across the …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Vaughn Vasil Smider · APPLIED BIOMEDICAL SCIENCE INSTITUTE · 2021 · $352,893 — Vaccines are the primary means by which to prevent, control, or eradicate infectious diseases. While many vaccines have been successfully developed and have resulted in enormous medical and veterinary benefit, there are certain viruses that have eluded effective vaccine development. Generally, virus…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Kimberly Frances Raab-Graham · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2021 · $335,999 — PROJECT SUMMARY Overview: The project focuses on understanding the molecular basis of how disrupted calcium homeostasis leads to disrupted hippocampal network activity that results in maladaptive responses in neurons with TSC deficient signaling. Approximately 33% of children who have autism spectru…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Brian T. Cunningham · STANFORD UNIVERSITY · 2021 · $742,137 — Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to-child HIV transmission, and a required element of routine diagnostic testing to make people aware of their HIV status. …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
YOSHIHIRO KAWAOKA · UNIVERSITY OF WISCONSIN-MADISON · 2021 · $7,000,324 — SUMMARY Most of the vaccines currently approved or in development against the pandemic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus target immunodominant, strain-specific epitopes in the SARS-CoV-2 spike (S) protein and are therefore not expected to confer protection against o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Duane R. Wesemann · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $11,809,995 — OVERALL SUMMARY Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV)-2 is a devastating human threat. While successful vaccine programs are underway, genetic drift and immune escape have already begun to subvert immunity, with more variants likely to continue to emerge. Moreover, the rates of …