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9873 documents

IMmunoPhenotyping Assessment of a Covid-19 Cohort (IMPACC): Immunophenotyping of innate and adaptive immune response to SARS-CoV-2 infection.

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

OFER LEVY · BOSTON CHILDREN'S HOSPITAL · 2020 · $308,143 — LAS PROJECT SUMMARY: From a cluster of respiratory illnesses in Wuhan, China, to a worldwide pandemic, the world has learned of a novel coronavirus (SARS-CoV-2) but little is known about the pathogenesis that leads to the disease termed “COVID”. Patients with SARS-CoV-2 infection range from asymptom…

NIEHS Gene Editing and Mouse Model (GEMM) Core Annual Report

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Manas Ray · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $1,546,971 — The NIEHS Gene Editing and Mouse Model (GEMM) core is a service orientated facility, which aims at helping investigators at the NIEHS to develop animal models to further their research and fulfilling the mission statement of NIEHS. The GEMM core aids investigators in generating transgenic mouse mode…

NIEHS Cryo-EM Core Facility

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Mario Borgnia · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $2,781,802 — The NIEHS Cryo-EM Core continues to lead the deployment and to promote the adoption of techniques in cryo-electron microscopy in the region. Over a dozen peer reviewed articles in high impact journals during FY2023 are a clear indication. The Core has played an important role in the intramural respo…

Integrative Bioinformatics

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Jian-Liang Li · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2023 · $2,970,345 — The Integrative Bioinformatics (IB) Support Group provides expertise in computational analysis and develops bioinformatics tools and resources to empower scientific research programs. Equipped with advanced computational infrastructure, including a comprehensive collection of bioinformatics software…

COVID-19 Clinical Support and Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Sarah Andrews · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $2,256,704 — In March 2020 the VIP began working in collaboration with VRC laboratories on the trial readouts for the Phase 1 DMID 20-0003 trial. Later that year the VIP was working within the Operation Warp Speed (OWS) (now called Countermeasures Accelerations Group) testing USG identified Covid-19 vaccines. T…

In Silico Screening for Cancer Targets

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

MARC NICKLAUS · DIVISION OF BASIC SCIENCES - NCI · 2023 · $138,509 — In collaboration with several Principal Investigators at the CCR/NCI, in silico screening of large small-molecule databases are being conducted for a number of molecular targets relevant for cancer. We are using the CADD Group's resources, including our screening databases to generate lists of compo…

India International Center for Excellence in Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Thomas Nutman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,250,220 — Our work focuses on the host response to helminth infection and pathogenesis of helminthic disease; immune responses in pulmonary and extrapulmonary tuberculosis; modulation of immune responses in tuberculosis by coinfections and comorbidities such as helminth infections, undernutrition, obesity, vi…

DATA MANAGEMENT FOR CANCER DIAGNOSIS PROGRAM ACTIVITIES

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

DAVE ANNETTE · INFORMATION MANAGEMENT SERVICES, INC. · 2023 · $842,461 — The National Cancer Institute (NCI) is an institute within the National Institutes of Health (NIH), one of eight agencies that compose the Public Health Service (PHS), Department of Health and Human Services (DHHS). The mission of the NCI is to plan, conduct, and coordinate the National Cancer progr…

Core D - Data Management and Bioinformatics Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Adolfo Garcia-Sastre · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $192,750 — PROJECT SUMMARY/ABSTRACT The SYBIL Data Management and Bioinformatics Core (DMBC) will support the Center's mission at all stages of research and publication by tracking projects and experiments, facilitating reproducible analysis, developing bioinformatic tools, and ensuring access and disseminatio…

NeuroMAP Phase II - Recruitment and Assessment Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

ROBIN L AUPPERLE · LAUREATE INSTITUTE FOR BRAIN RESEARCH · 2023 · $339,871 — PROJECT SUMMARY: Recruitment and Assessment Core Psychiatric research relies on the use of validated and reliable self-report, interview-based, and behavioral assessments to diagnose DSM-5 psychiatric disorders, estimate level of severity of mental health symptoms, and to delineate transdiagnostic c…

Biocontainment Research support services core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Farhang Alem · GEORGE MASON UNIVERSITY · 2023 · $717,476 — BIOCONTAINMENT RESEACRCH SERVICES: ABSTRACT Each of the twelve NIAID funded Regional Biocontainment Laboratories (RBLs) have distinguishing and complementary research capabilities to advance infectious disease and biodefense research. George Mason University’s (GMU)’s RBL, also known as the Biomedic…

Core 06: Biomedical Informatics Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Lucio Miele · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2023 · $294,412 — Project Summary: Biomedical Informatics Core The overall goal of the Biomedical Informatics (BMI) Core of the Louisiana Clinical and Translational Science Center (LA CaTS) is to build on our accomplishments and continue to develop and deploy “state of the art” informatics services to LA CaTS inve…

Core 2: BSL-3 Practices Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Scott Alderman · DUKE UNIVERSITY · 2023 · $920,265 — ABSTRACT – BSL-3 Practices Core (Core 2) The central mission of the Regional Biocontainment Laboratory Network is to provide a location and an environment in which groundbreaking research on potentially dangerous pathogens can be performed safely. As anyone with the responsibility of managing a lead…

SARS-CoV-2 protease inhibitors for treating COVID-19

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

ARUN K GHOSH · PURDUE UNIVERSITY · 2023 · $750,974 — Abstract The main objective of this project is to advance our extensive preliminary results and develop novel protease inhibitor drugs for the effective treatment of COVID-19. The COVID-19 pandemic, caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), eme…

NICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORK

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Myra Helen Wyckoff · UT SOUTHWESTERN MEDICAL CENTER · 2023 · $351,273 — PROJECT SUMMARY This proposal is a reapplication from the University of Texas Southwestern (UTSW) Medical Center to participate as a clinical center in the Eunice Kennedy Shriver NICHD Neonatal Research Network (NRN). Myra Wyckoff, MD became Principal Investigator (PI) in September 2013 and will rem…

2023 Liquid Crystals Gordon Research Conference & Gordon Research Seminar

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Cecilia Maria Leal · GORDON RESEARCH CONFERENCES · 2023 · $10,000 — Project Summary Significance, timeliness and rationale. NIBIB's mission is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment. Life would not be possible without liquid crystalline (LC) order. The most celebrated example is the uniqu…

The impact of vaping aerosol exposure on innate pulmonary defense mechanisms in nonhuman primates

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

Robert Blair · TULANE UNIVERSITY OF LOUISIANA · 2023 · $198,597 — PROJECT SUMMARY Vaping is a serious public health concern that was associated with outbreaks of hospitalizations and deaths in 2019. These outbreaks of electronic vaping associated lung injury (EVALI) coincided with increased use of electronic vaping devices by adolescents and young adults. The rapi…

Stanford/UNC Biomimetic U19 Research Center

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

MANUEL R AMIEVA · STANFORD UNIVERSITY · 2023 · $1,501,000 — Stanford/UNC Biomimetic U19 Research Center PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW Infectious diseases continue to pervasively afflict global health and socioeconomic stability despite substantial prevention and treatment initiatives. Respiratory and gastrointestinal pathogens rank amongst the m…

Interactions of SARS-CoV-2 infection and genetic variation on the risk of cognitive decline and Alzheimer’s disease in Ancestral and Admixed Populations

NIH Pandemic-Era Grants · Pandemic Era Grants / 2023

GABRIEL Alejandro DE ERAUSQUIN · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2023 · $8,725,158 — The science proposed in this program takes advantage of the unique scientific opportunity created by the ongoing coronavirus pandemic, to study the interaction between a definable and time-limited risk-inducing environmental event (exposure to the virus) and genomic variation on the occurrence of co…