Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
William Copeland · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $782,795 — We have established high-throughput structure determination workflows using single particle analysis cryo-EM (SPA). These workflows can solve the structure of macromolecular complexes at near atomic resolution in less than 24 hours. In collaboration with Dr. Robert Petrovich at the Protein Expressio…
Joseph Rodriguez · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $443,441 — Viruses use host components for their entire life cycle, from transcription and RNA processing of viral components to export and reinfection of new cells. ACE2 is an estrogen responsive cell receptor used by COVID19 to dock and enter host cells. TMPRSS2 is also an estrogen and androgen responsive …
Joel Moss · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $2,633,037 — A.Clinical and molecular effects of mTOR inhibitors: Patients with LAM and TSC are frequently treated with oral mTOR inhibitors. Sirolimus therapy of patients with LAM and TSC resulted in shrinkage of AMLs and stabilization of lung function, but discontinuation of sirolimus led to reversal of these …
Iain Fraser · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $38,806 — Cells of the innate immune system, such as dendritic cells and macrophages, constantly patrol host mucosal surfaces and peripheral tissues for signs of infection or injury. Since many people infected with SARS-CoV-2 clear the virus without developing symptoms, aspects of the innate immune response m…
Ursula Buchholz · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $698,609 — We are developing paramyxovirus vectored vaccines for intranasal immunization against SARS-CoV-2. These vectors express immunogenic versions of the SARS-CoV-2 S protein and are designed to be highly attenuated in humans while maintaining a high level of immunogenicity at the primary sites of infecti…
Raphaela Goldbach-Mansky · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $35,545 — In collaboration with the NIAID COVID consortium we have analyzed longitudinally collected whole blood samples collected for RNA isolation from 84 adult patients hospitalized with severe COVID. We also assessed serum samples from a larger panel of adult patients hospitalized with severe COVID (from …
KELLY G TEN HAGEN · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2021 · $2,025,039 — Loss of Galnt3 alters the oral microbiome and glycosylation of Muc10. The importance of the microbiome in health and its disruption in disease is continuing to be elucidated. However, the multitude of host and environmental factors that influence the microbiome are still largely unknown. Here, we e…
Nadya Tarasova · DIVISION OF BASIC SCIENCES - NCI · 2021 · $493,663 — Protein-protein interactions control practically all biological processes. Ability to manipulate these interactions is crucial for finding cures for the vast majority of human diseases. Conventional high-throughput screens for small molecule blockers of protein-protein interactions produce a disappo…
ANGELA K BIRNBAUM · UNIVERSITY OF MINNESOTA · 2024 · $539,430 — ABSTRACT Antiseizure medications are one of the most commonly prescribed teratogens. In pregnant women with epilepsy, continuation of antiseizure medications and dose increases are often necessary to prevent seizure worsening, but need to be balanced against the fetal risks of in utero exposure, suc…
SHU CHIEN · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $583,656 — Endothelial cells (ECs) play a critical role in regulating vascular functions. We and others have demonstrated that, through epigenetic and transcriptional regulations, laminar pulsatile shear stress (PS) induces athero- protective genes to maintain EC homeostasis, whereas disturbed flow with oscill…
Sebastian G. Schneeweiss · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $636,546 — Summary: Severe treatment recalcitrant atopic dermatitis (AD) is a debilitating condition with substantial population impact. Dermatology has experienced the emergence of targeted immuno-modulating drugs (IMDs) that have unprecedented efficacy in treating AD. Their optimal use is still unknown becau…
Christie Sennott · PURDUE UNIVERSITY · 2024 · $276,622 — Modified Project Summary/Abstract Section Access to reproductive healthcare in the U.S. has become increasingly constrained. Although a growing body of research has focused on identifying state-level policies that affect access to care, less attention has been paid to documenting access to reproduc…
Bolni Marius Nagalo · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $1,275,618 — ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer with limited treatment options and a low overall survival rate. Oncolytic viruses, particularly vesicular stomatitis virus (VSV), have shown promise in treating therapy-resistant cancers, including PDAC; however,…
Claire Elizabeth Jane Cheetham · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $332,860 — Project Summary/Abstract Understanding how endogenously-generated adult-born neurons functionally integrate into neural circuits may inform strategies employing stem cell-derived neurons to repair damaged brain areas. Olfactory sensory neurons (OSNs), which are generated throughout life in all mamma…
PHYLLIS L FAUST · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $595,333 — PROJECT SUMMARY/ ABSTRACT Essential tremor (ET) is the most common tremor disorder, affecting 2.2% of the total US population. ET is also a progressive disorder, with tremor becoming more severe over time. Despite its high prevalence, therapeutic options for ET are far from satisfactory, in part due…
Fen-Biao Gao · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $634,466 — ABSTRACT Frontotemporal dementia (FTD) is a progressive neurodegenerative disease associated with focal atrophy of the prefrontal and/or temporal lobes. FTD is the second most common form of dementia among people under the age of 65. Many FTD-causing genes have been identified during the last decade…
Bryan L. Roth · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $563,447 — ABSTRACT Chronic pain impacts a large proportion of the US population with estimates ranging from 10-40% of adults. Opioids and related medications are among the most frequently prescribed medications for treating chronic pain, albeit with considerable risks due to overdose, constipation, addiction…
WALTER J. CHAZIN · VANDERBILT UNIVERSITY · 2024 · $549,359 — The application of quantitative approaches to study biology and medicine is an essential underpinning for the advancement of biomedical research. This proposal requests support for the Molecular Biophysics Training Program (MBTP) at Vanderbilt University, which was founded in 1989. The goal of our p…
Justin Parent · UNIVERSITY OF RHODE ISLAND · 2024 · $358,407 — Project Summary Hispanic youth are nearly three times more likely to be at high risk for developmental, behavioral, or social delays compared to white non-Hispanic children. Contributing to this risk disparity is disproportionate rates of Hispanic children living in poverty and heightened risk for e…
Nan Gao · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $427,257 — PROJECT SUMMARY Crohn’s disease (CD) is a form of IBD that commonly involves small intestine, where the majority of Paneth cells reside. As a great number of CD patients show no response or refractory to standard treatment, there is an unmet need for new therapeutic options based on new mechanisms o…