Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Samuel Centanni · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $249,000 — PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicating potential sources for the motivation to consume alcohol. Alcoholics commonly list stressors and negative affective sta…
Weiwei Dang · BAYLOR COLLEGE OF MEDICINE · 2024 · $160,000 — PROJECT SUMMARY Many forms of human dementia are caused by aberrantly folded proteins and protein aggregates. Overexpressing these disease proteins, such as α-synuclein and TBD-43, in the budding yeast Saccharomyces cerevisiae, also causes cytotoxicity, allowing unbiased powerful genetic screens fo…
TOWIA A. LIBERMANN · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $870,666 — Project Summary/Abstract Delirium (acute confusion), is a major complication of surgery in older patients, strongly associated with long term cognitive decline (LTCD) and Alzheimer's Disease and Related Dementias (AD/ADRD). Prevention of postoperative delirium and its long-term complications would b…
Justin Courcelle · PORTLAND STATE UNIVERSITY · 2024 · $221,295 — Project Summary Near UV radiation (254nm light) induces DNA damage that blocks replication can result in genomic rearrangements when it resumes from the wrong place, mutagenesis when the incorrect base is incorporated opposite to the lesion, or cell death when the block to replication cannot be ove…
Venkateswaran Subramanian · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $494,578 — Abstract Abdominal aortic aneurysm (AAA) is a permanent dilation of the abdominal aorta with a high mortality greater than 80% after rupture. Aortic vascular smooth muscle cells (SMCs) are pivotal in maintaining aortic structural integrity and function, and SMC-rich aortic medial stability is highl…
Jeffrey M Kidd · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $475,800 — Abstract Short INterspersed Elements (SINEs) are mobile genetic elements that are present in all mammalian genomes. Most mammalian SINEs can be subdivided into two general categories: (1) those derived from 7SL signal recognition particle RNA (e.g., human Alu elements); and (2) those derived from t…
Sean C Murphy · UNIVERSITY OF WASHINGTON · 2024 · $829,705 — ABSTRACT Our U01 project supports NIAID’s mission to better understand, treat, and prevent infectious diseases by focusing on pre-erythrocytic malaria vaccine development. Vaccines that efficiently stop the Plasmodium sporozoite (spz) or liver stage can provide complete protection against malarial d…
Angela Ramona Branche · UNIVERSITY OF ROCHESTER · 2024 · $932,430 — The Vaccine and Treatment Evaluation Units (VTEUs) are a critical resource for the NIAID Infectious Diseases Clinical Research Consortium to conduct clinical research and trials to evaluate vaccines, preventive biologics, therapeutics, diagnostics, predictive markers, and devices for the treatment a…
Charles W. Flexner · JOHNS HOPKINS UNIVERSITY · 2024 · $2,176,002 — JHUBI PROJECT SUMMARY The proposed Johns Hopkins University Baltimore-India Clinical Trials Unit (JHUBI CTU) will combine three highly productive Clinical Research Sites (CRSs): the Johns Hopkins University (JHU) CRS at the JHU School of Medicine in Baltimore, the Byramji Jeejeebhoy Government Medic…
Gang Chen · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $408,889 — Idiopathic pulmonary fibrosis (IPF) is a progressive and end-stage lung disease of unknown etiology and no cure. It is likely that genetic changes increase a person's risk of developing IPF, and then exposure to certain environmental factors and/or aging trigger the onset of the disease. The MUC5B p…
Katherine A. Fitzgerald · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $490,775 — PROJECT SUMMARY (See instructions): The goal of this project is to understand mechanisms of gene regulation in the innate immune response. During the past many years, with support from this grant, we have pioneered work with fundamental implications to our understanding of inflammatory responses. …
Michael James Gough · PROVIDENCE PORTLAND MEDICAL CENTER · 2024 · $358,566 — The critical preliminary data for this proposal is that contrary to the accepted dogma, following exposure to endogenous immune adjuvants MyD88 delivers a negative signal to macrophages that limits tumor control by radiation therapy. We demonstrate that in poorly immunogenic tumors, macrophages are …
Resham Bhattacharya · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $78,953 — Nanoparticles (NPs) have mostly been used as delivery vehicles for various biomedical applications. When exposed to biological fluids NPs interact with proteins forming a biological coating on their surface, termed protein corona. Protein corona around NPs have been investigated to address the biolo…
BRIAN Joseph MITCHELL · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $328,000 — Project Summary: The ability of cells to migrate in a directed manner is critical to a variety of biological processes including morphogenesis, would repair, immunological response and cancer progression. A key feature of migration in an in vivo setting is the ability to break through junctional bar…
Joseph W. Labrie · LOYOLA MARYMOUNT UNIVERSITY · 2024 · $669,973 — Project Summary Underage drinking on college campuses remains a serious public health issue. Research suggests that Parent- Based Interventions (PBIs) that target parents of incoming students can be powerful adjuncts to existing student-level alcohol programs. Although Turissi’s Parent Handbook is t…
Ozgur Sahin · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $352,295 — PROJECT SUMMARY Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype. It accounts for ~15% of all breast cancer patients yet is responsible for 30% of breast cancer deaths. TNBC is treated primarily by conventional chemotherapy; however, resistance to therapy is common l…
Jonathan Elmer · STANFORD UNIVERSITY · 2024 · $1,155,493 — Project Summary The objective of PREcision Care In Cardiac ArrEst - ICECAP (PRECICECAP) is to discover novel biomarker signatures of post cardiac arrest brain and extracerebral organ failure that predict treatment responsiveness and long-term recovery. We will achieve this by partnering with the ICE…
Stanley M. Lemon · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $518,380 — PROJECT ABSTRACT Hepatitis A virus (HAV) is an unusual picornavirus (genus Hepatovirus) that is released without lysis from infected hepatocytes within small extracellular vesicles (EVs) resembling exosomes. These membrane-cloaked virions, or `quasi-enveloped' HAV (eHAV), lack virus-encoded glycopro…
Juhun Lee · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $330,868 — Most women in the USA who have dense breasts at screening mammography receive a letter notifying them that mammography is less effective for them and having dense breasts increases the risk of breast cancer. The letter advises women to talk with their physician whether they should have additional sc…
Patricia Manuela Ribeiro Pereira · WASHINGTON UNIVERSITY · 2024 · $601,992 — PROJECT SUMMARY/ABSTRACT – The incidence of gastric and breast cancers is increasing rapidly, rating fourth and fifth leading causes of cancer mortality worldwide. In patients clinically classified as HER2-positive (ERBB2 amplification and/or 2+/3+ protein overexpression by immunohistochemistry), an…