Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Waldemar Debinski · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $565,969 — SUMMARY Treatment of glioblastoma (GBM) represents an unmet need in medicine. We have been pursuing a therapeutic approach of delivering potent targeted and specific cytotoxins using continuously evolving convection-enhanced delivery. Patients with GBM over-express interleukin 13 receptor alpha 2 (I…
Rodney Britt · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $445,231 — PROJECT SUMMARY Asthma remains a significant healthcare burden for children and has a long-term impact on their development and health. Inhaled corticosteroids are key for managing asthmatic symptoms and disease progression. However, children with severe asthma are insensitive or resistant corticos…
Juan Gabriel Santiago Moreno · UNIVERSITY OF COLORADO DENVER · 2024 · $37,404 — PROJECT SUMMARY The ability to integrate color and form into coherent visual scenes is an important part of our interactions with the environment. This ability is impaired in many ophthalmologic and neuropsychiatric disorders, yet the neural mechanisms responsible for visual feature integration rema…
Eileen T. Krepkovich · BARRON ASSOCIATES, INC. · 2024 · $951,526 — PROJECT SUMMARY/ABSTRACT Significance: The Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy (“KneeBRIGHT”) system combines electromyography (EMG) biofeedback with video game therapy (VGT) to provide knee osteoarthritis (OA) patients with an engaging, effective tool for conductin…
Larry R Squire · VA SAN DIEGO HEALTHCARE SYSTEM · 2024 — Project Summary/Abstract (1) Our work is directed towards understanding the structure, organization, and anatomy of human memory. We study neurological patients who have circumscribed memory impairment as the result of brain injury or disease that has damaged the hippocampus bilaterally. We also st…
Emilie T. Reas · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $781,184 — PROJECT SUMMARY COVID-19 is associated with cognitive impairment that may persist long after infection. COVID-19 risk factors overlap with those for Alzheimer’s disease (AD), including older age, the APOE4 allele, and vascular dysfunction, suggesting that pathology from one condition may exacerbate…
Kaitlin M Love · UNIVERSITY OF VIRGINIA · 2024 · $192,031 — PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is markedly elevated in type 1 diabetes (T1D), and two prevalent conditions in T1D, insulin resistance and endothelial dysfunction, precede and predict CVD. In health, insulin action at the endothelial cell dilates blood vessels, which promotes g…
Jeffery D Molkentin · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $595,777 — Abstract Like skeletal muscle myofibers, cardiomyocytes in the heart constantly adjust their size based on perceived workload or disease stimulation, in which hypertrophic versus atrophic pathways are in balance to achieve an appropriate equilibrium matched to real-time workloads. In a less apprecia…
Annarita Di Lorenzo · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $575,444 — Inflammatory macrophages play a key role in the development and progression of the atherosclerosis, leading to myocardial infarction (MI). Sphingolipids are both membrane components and signaling molecules. Ceramide and Sphingosine-1-phosphate (S1P), bioactive and interchangeable sphingolipids, regu…
Thomas A Blanpied · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $685,384 — Mechanisms that create, maintain, and modulate synapses are essential building blocks of human behavior. Disruptions to these mechanisms are inextricably linked to aberrant behavior and diseases ranging from depression and schizophrenia to addiction and Alzheimer’s Disease. Thus, the long-term goal …
Qian Sun · CASE WESTERN RESERVE UNIVERSITY · 2024 · $395,118 — PROJECT ABSTRACT The hippocampus is essential for memory formation and spatial navigation. In the classic hippocampal trisynaptic circuit (entorhinal cortex→dentate gyrus→CA3→CA1), dentate gyrus and CA1 act as the primary input and output areas, respectively, that connect the hippocampus with the br…
Jatinder K. Lamba · UNIVERSITY OF FLORIDA · 2024 · $636,388 — ABSTRACT: Acute myeloid leukemia (AML) is a rare, devastating, and understudied malignancy with ~20,00 new cases and around 61,000 cases in US. Though intensive chemotherapy primarily consisting of ara C (also known as cytarabine), daunorubicin, and etopside have been used to treat AML for over 4 de…
Francisco J Alvarado · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $604,478 — ABSTRACT Sympathetic stimulation of ventricular myocytes activates PKA, which phosphorylates L-type Ca2+ channels and phospholamban, among other substrates, to increase Ca2+ entry and SR Ca2+ uptake. This β- adrenergic-induced increase of intracellular Ca2+ (Ca2+ overload) is a natural and efficien…
Charlotte M Vines · UNIVERSITY OF TEXAS EL PASO · 2024 · $76,750 — TITLE: Development of a Mouse model to test targeted therapy to prevent CNS Invasion by Pediatric T- ALL Abstract Leukemia is the most frequent pediatric cancer with acute lymphoblastic leukemia (ALL) being the most common leukemia type in children. In 15-20% of pediatric T-cell ALL (T-ALL) patients…
MARIA LEHTINEN · BOSTON CHILDREN'S HOSPITAL · 2024 · $565,326 — PROJECT SUMMARY Post-hemorrhagic hydrocephalus (PHH) is a leading cause of morbidity in premature infants. PHH is triggered by germinal matrix intraventricular hemorrhage (IVH) that results in accumulation of cerebrospinal fluid (CSF) in the brain compression of surrounding brain tissue, and permane…
Laura Murray-Nerger · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $76,984 — PROJECT SUMMARY/ABSTRACT Epstein-Barr virus (EBV) is spread through saliva, infects oropharyngeal tissues including the tonsillar epithelium, and establishes life-long latency in the B-cell compartment in over 95% of the global adult human population. The oral transmission of EBV can result in infec…
Margarita Brovkina · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $32,207 — Project Summary Animals of many species develop as two anatomic sexes that perform distinct and complex social behaviors. Across clades, master regulator transcription factors downstream of sex determination programs “switch” distinct brain regions and neurons involved in sex-typical behaviors by a…
Jason A Burdick · UNIVERSITY OF PENNSYLVANIA · 2024 · $516,327 — Abstract Fibrous tissues of the musculoskeletal system (e.g., the knee meniscus) are plagued by their poor intrinsic healing capacity. In the previous funding cycles, we developed enabling technologies including multi-fiber scaffolds to introduce various temporal and structural signals towards the r…
Chen Liu · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $393,599 — PROJECT SUMMARY A heterozygous missense mutation OtpQ153R/+ has recently been discovered in a cohort of individuals with severe, early-onset obesity. Like many other obesity-associated variants, despite a strong association, a causal relationship has yet been established. Otp encodes a transcription…
Nami McCarty · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $351,975 — Abstract: Multiple myeloma (MM) is an incurable B cell malignancy that is characterized by the growth of neoplastic plasma cells within the bone marrow microenvironment. Despite progress in the clinical treatment of MM, including the use of high-dose chemotherapy and autologous stem cell transplanta…