NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Arabella Young · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $249,000 — Project Summary/Abstract Tumors elicit a range of suppressive mechanisms in order to evade the immune system. Many of these are targetable as evidenced by the great success of cancer immunotherapies that boost a patient's own immune response towards cancer. Often, targets for cancer immunotherapies …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Gary K Owens · UNIVERSITY OF VIRGINIA · 2024 · $777,063 — Atherothrombosis, resulting from rupture or erosion of unstable atherosclerotic plaques, is the leading cause of death worldwide. However, the mechanisms that regulate the stability of late stage atherosclerotic lesions remain poorly understood. Recent studies from our lab (2021 Nature Metabolism) s…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
AMBER M GUM · UNIVERSITY OF SOUTH FLORIDA · 2024 · $565,489 — ABSTRACT In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, we have partnered with senior center stakeholders to simplify Behavioral Activation (BA) to match the skill set of lay volunteers (“Do More, Feel Better…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mark H Schoenfisch · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $366,170 — SUMMARY The delayed healing observed in chronic wounds is exacerbated by persistent microbial infections and non- resolving inflammation. Furthermore, the emergence of antibiotic-resistant bacteria has limited the use of these agents for treating infected wounds. Adding to the complexity of chronic …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Hannah Shorrock · STATE UNIVERSITY OF NEW YORK AT ALBANY · 2024 · $99,246 — Project Summary CAG repeat expansion diseases are the most common class of microsatellite expansion disorders. While canonical translation of the CAG repeat leads to the production of polyglutamine proteins, these expansions can also undergo non-canonical repeat associated non-AUG (RAN) translation.…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Abeer M Mohamed · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $712,972 — ABSTRACT The development of type II diabetes (T2D) is strongly associated with obesity, and both are well-established risk factors for cardiovascular disease. Vascular dysfunction is an early event in developing cardiovascular disease in obese diabetic (OB-T2D) patients. Therefore, we set our long-t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jalees Rehman · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $563,095 — PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory cells such as neutrophils and macrophages. This maladaptive inflammatory response outpaces the reparative capacity of lungs…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Prakash Chinnaiyan · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · 2024 · $323,500 — ABSTRACT Glioblastoma (GBM) continues to be an invariably fatal malignancy with limited treatment options. Our laboratory studies tumor metabolism and its potential to serve as a novel therapeutic target. Through a series of investigations, our group has identified that the diverse tumor ecology imp…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ERIC HERMES · VA CONNECTICUT HEALTHCARE SYSTEM · 2024 — Background: As many as 1.8 million individuals using VA services meet criteria for insomnia disorder, a condition associated with suicide, poor functioning, and medical and mental health disorders. Cognitive Behavioral Therapy for insomnia (CBTi) is the gold-standard treatment. However, only a small…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Magdalena Maria Gorska · NATIONAL JEWISH HEALTH · 2024 · $610,821 — Project Summary/Abstract A growing number of epidemiological studies link childhood asthma with maternal environmental exposures with the strongest evidence provided for diesel exhaust and cigarette smoke. How maternal exposures lead to asthma in offspring is unknown. To address this, we developed a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Armina-Lyn M Frederick · DARTMOUTH COLLEGE · 2024 · $45,446 — ABSTRACT Metabolic dysregulation is the major preventable risk factor for leading causes of chronic disease-related deaths. More specifically, chronic obesity is correlated with adipocyte hypertrophy and hyperplasia, both of which may be circadianly regulated. All circadian clocks are cell-intrinsi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Andrew Caleb Hsieh · FRED HUTCHINSON CANCER CENTER · 2024 · $412,243 — ABSTRACT (from parental grant) The recent advent of highly potent inhibitors of the androgen receptor and androgen biosynthesis has had the unfortunate iatrogenic effect of fueling new lethal prostate cancer phenotypes in patients. In particular, non- neuroendocrine androgen receptor-low castration …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Andrew Edward Anderson · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $435,356 — PROJECT SUMMARY By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis (OA) cases. FAIS patients present with a loss of sphericity of the femoral head, reduction in femoral-neck offset, and/or an excessively prominent acetabular wall. Patients report …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mary-Louise Risher · HUNTINGTON VETERANS AFFAIRS MED CTR · 2024 — Operation Enduring Freedom in Afghanistan and Operation Iraqi Freedom (OEF/OIF) studies report that combat veterans are at increased risk for binge drinking and the development of alcohol use disorder (AUD). 38% of Army active duty members surveyed returning from OEF/OIF deployments between 2008 and…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sanjeev Chawla · UNIVERSITY OF PENNSYLVANIA · 2024 · $372,319 — Abstract Glioblastoma therapy. delivered to Despite promising clinical outcomes, significant (GBM) is the deadliest of all brain cancers with a dismal prognosis despite aggressive multi-modal T umor treating fields (TTFields) are a recently approved loco-regional and noninvasive therapy by placing …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Trishala Chari · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $25,859 — PROJECT ABSTRACT Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by deficits in social interaction, repetitive behaviors and atypical sensory processing. The change in quality of life in ASD individuals is primarily attributed to social deficits, which can be associat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
John Macky Marshall · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $310,137 — PROJECT SUMMARY/ABSTRACT: Dengue, Chikungunya, Zika and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. Consequently, there is interest in novel strategies to…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Arnaldo Carreira-Rosario · DUKE UNIVERSITY · 2024 · $223,931 — Project Summary Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations during this time can cause lifelong circuit and behavioral changes. Not surprisingly, mounting evidence suggests that several neurodevelopmental disorders, including autism spect…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Anatoly Zhitkovich · BROWN UNIVERSITY · 2024 · $365,625 — Project Summary Mutations in various oncogenes and tumor-suppressor genes as well as other genome rearrangements are a principal cause of human cancers. Lung tumors have especially high burdens of mutations. Despite this dependence of cancer development on multiple genetic events, many human lung ca…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ian Cohn · UNIVERSITY OF PENNSYLVANIA · 2024 · $29,474 — Project Summary The apicomplexan parasite Cryptosporidium is a leading cause of diarrhea and death in immunocompromised individuals and malnourished children globally. Control of Cryptosporidium requires CD4+ T cells and the cytokine interferon-γ (IFN-γ), however there are significant gaps in our und…