Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
CHARLES Louis EDELSTEIN · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — Cardiac disease, is a common cause of death in PKD patients. Study of the mechanisms of cardiac hypertrophy, beyond hypertension, is an unmet need. Furthermore, testing of novel agents that block mTORC1/2 outputs e.g. 2nd, 3rd and 4th generation mTORC1/2 inhibitors and palmitate conjugated ASOs that…
Constanza Garcia Keller · MEDICAL COLLEGE OF WISCONSIN · 2024 · $248,999 — Converging epidemiological studies indicate that a life-threatening event increases the incidence of post- traumatic stress disorder (PTSD), which carries a 30-50% comorbidity with substance use disorders (SUDs). Such comorbidity results in greater drug use and poorer treatment outcomes. The propose…
Sarah Yip · YALE UNIVERSITY · 2024 · $722,366 — Abstract Opioid use disorder (OUD) is a significant public health problem with opioid-associated overdoses and deaths reaching epidemic levels in recent years. Methadone and buprenorphine are widely used and generally effective medications for OUD (MOUDs). However, relapse and nonadherence rates rem…
Camila Margarita Manrique Acevedo · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · 2024 — PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in Veterans with type 2 diabetes (T2D). Lifestyle modifications, including increased physical activity, are recommended as first-line therapy for the management of T2D. Unfortunately, the efficacy of these lifestyle…
Bo Liang · EMORY UNIVERSITY · 2024 · $391,250 — PROJECT ABSTRACT The long-term goal of our project is to elucidate the molecular basis of the poorly understood mechanism of the RNA synthesis machinery of NNS RNA viruses and to determine the structures of key protein complexes involved in the RSV RNA synthesis, facilitating the development of anti…
NATHAN E CRONE · JOHNS HOPKINS UNIVERSITY · 2024 · $2,019,539 — For many years brain-computer interfaces (BCI's) have been explored as a means of restoring communication to patients with Locked-In Syndrome (LIS), a devastating and often irreversible neurological condition in which cognition is intact but nearly all motor output from the brain is interrupted, eff…
Rafael Guerrero-Preston · LIFEGENE-BIOMARKS, INC. · 2024 · $275,767 — Project Summary No woman should die from cervical cancer. We have the technical, medical and policy tools and approaches to eliminate it. Yet, one woman dies of cervical cancer every two minutes. Cervical cancer is the third leading malignancy among women in the world, after breast and colorectal ca…
Jeff W. Bulte · JOHNS HOPKINS UNIVERSITY · 2024 · $519,965 — Our overall aim is to develop a precision-based nanotheranostic platform where the imaging signal may serve as an early predictive imaging biomarker for intracellular nanoparticle accumulation and therapeutic response. New anti-cancer agents continue to be developed, but many fail due to the tumor d…
L Elliot Elliot Hong · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $770,374 — Project Summary / Abstract Vascular biology and white matter may be some of the key junctures that harbor early risk mechanisms that precipitate vascular contributions to cognitive impairment and Alzheimer's disease. This process may start as early as adolescence and young adulthood, and through our…
Satish K Madala · UNIVERSITY OF CINCINNATI · 2024 · $449,264 — PROJECT SUMMARY Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease that is incurable and progressive due to fibroblast activation, and the formation of scar tissue. Approximately 130,000 Americans suffer from IPF, with an estimated 50,000 new cases diagnosed each year. Although it …
Nicholas Holder · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — Background: Posttraumatic stress disorder (PTSD) is one of the most common mental health diagnoses among Veterans. Cognitive processing therapy (CPT) and prolonged exposure therapy (PE) were widely disseminated in the Veterans Health Administration (VHA) as recommended PTSD treatments. Despite these…
Anna Greka · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $390,369 — SUMMARY Chronic kidney diseases affect more than 700 million people worldwide, and are a frequent cause of kidney failure and death. A key event leading to kidney failure is filter damage, caused by the loss of podocytes. This is a cause of a kidney disease known as Focal segmental Glomerulosclerosi…
Melissa Berrien Elliott · SAINT LOUIS UNIVERSITY · 2024 · $186,030 — PROJECT SUMMARY Candidate: During my training, I have been highly motivated to understand how cytotoxic lymphocytes can be used as an adoptive therapy and how immune cells are regulated during immunotherapy. I have served as first, co-, and corresponding author on numerous high-impact original resea…
Michelle M. Hilgeman · TUSCALOOSA VETERANS AFFAIRS MEDICAL CTR · 2024 — Background: VA Community Living Center (CLC) staff struggle to address behavioral and neuropsychiatric symptoms of Veterans with dementia and serious mental illness (SMI) such as schizophrenia. These behaviors of distress (agitation, aggression, and mood disturbance) are not just associated with sta…
MICHAEL L BOEHNKE · BROAD INSTITUTE, INC. · 2024 · $3,320,255 — Abstract Despite much progress in mapping genetic associations for T2D, its complications, and related traits, the underlying causal variants, effector genes, and gene networks are not well understood. The AMP-T2D consortium aims to accelerate the pace by which these disease mechanisms are elucidat…
A.M. Rostami · THOMAS JEFFERSON UNIVERSITY · 2024 · $390,000 — SUMMARY ThGM Cells in CNS Autoimmunity ThGM cells (ThGM-CSF) are a newly described Th subset characterized by production of GM-CSF, but lacking expression of signature cytokines and master transcription factors (TF) for established Th cell lineages. In our analysis, ThGM cells were notably more abun…
Jianjun Guan · WASHINGTON UNIVERSITY · 2024 · $548,332 — ABSTRACT Fracture nonunion poses a significant clinical problem. In the United States, approximately 1.6 million bone fractures encounter prolonged healing or nonunion each year. Fracture nonunion treatment usually involves complicated and massive procedures in practice, and sometimes needs multiple…
Siobhan Marie Phillips · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $596,996 — PROJECT SUMMARY/ABSTRACT FROM THE PARENT GRANT APPLICATION Increased moderate to vigorous intensity physical activity (MVPA) is associated with reductions in treatment- related side effects, cancer recurrence and mortality and increased QOL and survival in breast and endometrial cancer survivors. Ho…
AUDREY L JONES · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 — Background: My long-term goal is to become an independent VA health services researcher focused on designing and testing integrated care solutions to improve mental health and substance abuse (MHSA) services access, quality, and outcomes for vulnerable Veteran populations. This CDA-2 will provide me…
Jorge Antonio Antonio Gutierrez · DURHAM VA MEDICAL CENTER · 2024 — The present study aims to increase Veteran access to supervised exercise therapy and expand its role in improving functional status, quality of life, and cardiovascular risk profile of Veterans with PAD. To accomplish these goals, we will use the VA Telehealth service to deploy a remotely accessible…