Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Susana R Patton · NEMOURS CHILDREN'S CLINIC · 2024 · $546,251 — PROJECT SUMMARY/ABSTRACT Young children with type 1 diabetes (T1D) remain highly vulnerable to episodes of hypoglycemia despite the introduction of new insulin analogs, insulin pumps, and continuous glucose monitors (CGM). Parents and young children living with T1D quickly learn to fear hypoglycemia…
AIMEE L MCRAE-CLARK · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — Tobacco and cannabis are commonly used together in the Veteran population and result in significant morbidity; to date, however, advancements in medication development for this comorbidity have been limited. Varenicline, a selective nicotinic nACH receptor partial agonist of the α4β2 subtype and a f…
Rita Marie Cowell · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $500,973 — PROJECT SUMMARY Controversies exist regarding the contribution of glial cell dysregulation and inflammation to the pathogenesis of Parkinson Disease (PD). Signs of inflammation have been detected in postmortem tissue of PD patients, and recent evidence suggests that mutations in genes associated wi…
Anusha Kalbasi · STANFORD UNIVERSITY · 2024 · $228,439 — PROJECT SUMMARY Despite chemotherapy, radiation and surgery, patients with undifferentiated pleomorphic sarcoma (UPS) frequently suffer incurable disease relapse. Immune checkpoint blockade is a promising new therapeutic approach for patients with UPS which promotes T cell mediated anti-tumor immuni…
ALEXANDER C TSAI · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $411,136 — ABSTRACT Numerous studies have documented racial & ethnic disparities in sleep deficiency among adolescents & adults. These disparities are thought to be explained partially by experiences of interpersonal racial discrimination. What remains lacking is knowledge of the causal mechanisms linking stru…
Steve Onyeka Oghumu · OHIO STATE UNIVERSITY · 2024 · $472,500 — PROJECT SUMMARY/ABSTRACT There is a sex-based disparity associated with substance abuse disorders, which is evidenced by preclinical and clinical studies. Females are generally more vulnerable to the initiation, escalation and withdrawal effects of substance abuse behavior than males. Although these…
Guneet Jasuja · EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL · 2024 — Background: Transgender people experience discord between their gender identity and birth sex, defined as gender dysphoria. Gender-affirming treatments (GATs) are medically necessary treatments to reduce gender dysphoria. However, among transgender Veterans (trans Vets) who desire GATs, not much is …
Elizabeth Anne Thompson · JOHNS HOPKINS UNIVERSITY · 2024 · $162,000 — PROJECT SUMMARY This is a proposal for a two-year career transition award to study atypical B cells as a novel immunologic and metabolic target to improve vaccine responses in immunosuppressed individuals. The candidate is currently a postdoctoral research fellow at the Johns Hopkins University Scho…
Boyang Wu · WASHINGTON STATE UNIVERSITY · 2024 · $332,489 — Project Summary/Abstract (Parent Grant Application) Prostate cancer (PC) is the most common non-skin cancer in American men, with a lifetime incidence of 1 in 7, and also the second leading cause of cancer death in American men. Androgen receptor (AR) is the primary oncogenic driver of PC growth, su…
DAVID H WANG · VA NORTH TEXAS HEALTH CARE SYSTEM · 2024 — Project Summary Esophageal cancer has a higher incidence rate in US veterans than the general population, and its prognosis is generally poor with a five-year overall survival rate of less than 20%. While most clinical trials focus on patients with metastatic esophageal cancer, novel therapies added…
Le Cong · STANFORD UNIVERSITY · 2024 · $473,100 — Project Abstract Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9 Exemplified by the CRISPR-Cas9 system, gene-editing technology is a powerful collection of tools for probing the hidden mechanisms of human diseases by understanding and controlling the functions of human genome variants…
Jerod L Stapleton · UNIVERSITY OF COLORADO DENVER · 2024 · $571,997 — PROJECT SUMMARY Among the devastating illnesses impacting rural America, few exact the physical, social, psychological, and economic toll of lung cancer. Lung cancer is the leading cause of cancer death in rural America, and the levy is particularly acute in Kentucky – a state that not only leads th…
Alexandra P Ikeguchi · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $218,011 — Adoptive cellular therapy and therapeutic cancer vaccines have shown promise in solid tumor malignancies but responses have generally been modest. By combining these two modalities in a rationally designed first-in- human study, we propose to treat patients with a highly-defined T cell product (comp…
ARIE KAFFMAN · YALE UNIVERSITY · 2024 · $419,367 — Project Abstract Exposure to unpredictable and complex stress early in life increases the risk for developing anxiety disorder and abnormal connectivity between the amygdala, the prefrontal cortex (PFC), and the hippocampus (HPC). Exactly how early life stress (ELS) modifies fronto-limbic connectivi…
ARNOLD KRIEGSTEIN · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,039,070 — A major long-term goal of this proposal is to understand human brain development and the origins of neurodevelopmental diseases. The cerebral cortex is a structure where model systems, such as mouse or rat, may not capture the complexity of architecture and function relevant for understanding human …
Mariana Angoa-Perez · JOHN D DINGELL VA MEDICAL CENTER · 2024 — Project Summary/Abstract Traumatic brain injury (TBI) has been referred to as the “signature injury” of recent military combat operations in Iraq and Afghanistan. The form of TBI that is most prevalent among military service members and Veterans is repetitive, mild TBI, or rmTBI. Apart from the imme…
Michael Anthony Cucciare · CENTRAL ARKANSAS VETERANS HLTHCARE SYS · 2024 — Project Summary/Abstract Background: Relatively few Veterans screening positive for hazardous drinking in primary care (PC) receive alcohol care in the year following their alcohol screening. This suggests that existing VHA options for linking Veterans in need of alcohol care, including those with c…
Seyedhamidreza Alaie · NEW MEXICO STATE UNIVERSITY LAS CRUCES · 2024 · $133,915 — Abstract While wireless monitoring of intracardiac pressure using implants is essential for the management of heart failure, miniaturizing these implants is critical for reducing their associated complications. Current implants mainly consist of an electromagnetic antenna, electronics, and energy-st…
STEPHEN S LEFF · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $573,901 — ABSTRACT The proposed study is in direct response to two gaps in school-based aggression prevention programming and research. First, there are very few culturally-sensitive relational aggression prevention programs with documented success among high-risk urban minority girls and their classmates des…
Shane P Crotty · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $867,163 — Abstract/Project Summary HIV-1 envelope glycoprotein (Env) is the sole target for development of antibody-mediated immune response. Studies of patients infected with HIV have led to the isolation of antibodies against different epitopes on the Env surface, capable of neutralizing a broad range of c…