Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jennifer A Kearney · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $472,020 — Epilepsy is a common neurological that will affect 1 in 26 Americans during their lifetime. Mutations in SCN1A, encoding the neuronal voltage-gated sodium channel Nav1.1, are the most common genetic cause of epilepsy. Over 1600 SCN1A mutations have been reported in individuals with epilepsy of varyi…
Tien Peng · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $545,713 — Project Summary/Abstract Aging is one of the biggest risk factors for many chronic lung diseases, including idiopathic pulmonary fibrosis (IPF). However, uncertainties remain as to how age-related processes contribute to the pathogenesis of IPF, particularly in deciphering the cell types that might …
Nagaraj S. Nagathihalli · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $329,883 — PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is characterized by resistance to current therapies, a high degree of desmoplasia, and an immunosuppressive tumor microenvironment (TME). This scientific proposal focuses on cyclic AMP Response Element Binding protein 1 (CREB) as a transcriptio…
FREDERICK LEWIS ALTICE · YALE UNIVERSITY · 2024 · $297,920 — Despite an array of evidence-based interventions (EBIs) to address HIV – and the 90/90/90 strategy – the HIV epidemic in Malaysia remains volatile. With over 100,000 cumulative HIV cases, Malaysia's rapidly expanding HIV epidemic is the fifth largest in the Asia-Pacific region and concentrated withi…
Eleni Linos · STANFORD UNIVERSITY · 2024 · $164,745 — Skin disease is constantly changing over time; rashes flare, moles grow, ulcers heal, and chronic skin disease severity fluctuates over time. Patients only see dermatologists at infrequent and irregular intervals that do not match the clinical course of the disease. As clinicians and researchers do …
SATHISH KUMAR · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $343,881 — ABSTRACT Pregnancy-induced vascular adaptations, adequate placental vascularization, and optimal flux of nutrients across the placenta to the fetus are critical to support fetal growth. Disruption in one or more of these processes leads to fetal growth restriction (FGR). FGR affects up to 15% of all…
Sage J. Kim · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $603,011 — ABSTRACT This application proposes to examine a novel social epigenetic mechanism for racial inequality in lung cancer: Reducing racial disparities in lung cancer outcomes by decoding neighborhood contextual environment (RECODE). We will examine the relationships between exposure to violence, inflam…
JOHN H WEISS · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $544,831 — 7. Project Summary/Abstract Therapy for ischemic brain injury is poor in part because of our limited understanding of mechanisms leading to neuronal loss. While roles of excessive glutamate release and neuronal Ca2+ accumulation have been much studied, recent evidence implicates critical contributi…
Daniel K Mulkey · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $511,535 — SUMMARY Rett syndrome (RTT) (OMIM #312750) is a severe X-linked neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2). Although RTT patients suffer from many co-morbid phenotypes, wake disordered breathing has a major negative impact quality of life and is assoc…
MARNIE E HALPERN · DARTMOUTH COLLEGE · 2024 · $498,270 — ABSTRACT/PROJECT SUMMARY The habenulo-interpeduncular pathway, a forebrain to midbrain conduction system in the vertebrate brain, has been implicated in many essential processes, from sleep to fear/anxiety, pain, learning, motivation, feeding, reproduction, and reward, and in pathological states s…
Oguz Akbilgic · UNIVERSITY OF WASHINGTON · 2024 · $92,786 — Project Summary Atrial fibrillation (AF) is the most common cardiac arrhythmia responsible for significant morbidity and mortality burden. Obstructive sleep apnea (OSA) is a common sleep disorder but disproportionately more common in patients with AF. OSA has been proposed as a risk for AF. However,…
Sarah Elizabeth Champagne · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $24,651 — Project Summary The ability to access complex target molecules with sustainable methodology is imperative to the development of novel drugs, which will be necessary to treat antimicrobial resistance and emerging infectious diseases.1 Site- selective oxidation reactions are fundamental to the current…
Mariah L Arral · CARNEGIE-MELLON UNIVERSITY · 2024 · $45,094 — PROJECT ABSTRACT The goal of this research is to study the influence of age on the delivery processes required for lipid nanoparticle-mediated mRNA vaccination, with a long-term goal of improving vaccination outcomes in the elderly. In the next thirty years, our elderly population will double, exce…
JASON K STUMPFF · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2024 · $431,434 — PROJECT SUMMARY The accurate segregation of chromosomes by the microtubule-based mitotic spindle during mitosis is essential for the preservation of genomic integrity. Errors in mitotic spindle function lead to chromosome missegregation, aneuploidy, and the formation of micronuclei, all hallmarks of…
Abhijit A Date · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $1,094,442 — Infection-associated blindness caused by herpesviruses is a leading cause of vision loss in the United States. Frontline therapies include the use of nucleoside analogs such as acyclovir which inhibit the viral thymidine kinase to restrict viral DNA replication. However, emergence of drug resistance…
JEFFREY H WITHEY · WAYNE STATE UNIVERSITY · 2024 · $188,180 — PROJECT SUMMARY Cholera is presently caused by O1 serogroup, El Tor biotype V. cholerae, which emerged in 1961 to initiate the ongoing seventh pandemic. The prior 6 cholera pandemics were caused by O1 serogroup classical biotype V. cholerae. Over the past 60 years, classical biotype has essentially …
Lie Gao · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $508,114 — PROJECT SUMMARY The goal of this study is to elucidate novel mechanisms underlying exercise training (ExT)-induced sympatho- inhibition in chronic heart failure (CHF) (Aim 1) and cardioprotection following acute coronary ischemia/reperfusion (I/R) (Aim 2), based on an innovative concept of inter-org…
Natalie Christine Benda · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $243,633 — PROJECT ABSTRACT/SUMMARY Severe maternal morbidity (SMM) rates have risen 120-200% in the United States in the past two decades,1 and experts estimate that 40-60% of these cases are preventable.2,3 Suicide or self-harm related to postpartum psychiatric issues, although typically reported separately …
Anna Valujskikh · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $596,809 — ABSTRACT Acute and chronic antibody-mediated rejection (AMR) is a serious threat to the survival and function of transplanted organs. The current options for AMR prevention and treatment are limited by the incomplete understanding of the mechanisms underlying donor specific alloantibody (DSA) genera…
Zachary G Baker · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $242,339 — Project Summary / Abstract Within 10 years, most persons living with Alzheimer’s disease and related dementias (AD/ADRD; PLWD) will die, creating 13+ million new bereaved AD/ADRD caregivers. 25% of bereaved AD/ADRD caregivers have clinically ‘complicated grief’, which impairs nearly all aspects of t…