Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
ROBERT A. BONOMO · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2024 — Agencies that fund medical research are under increasing pressure to translate funded research projects to commercial entities. These commercial entities can obtain the necessary external capital needed to advance the technology to a point where it will change health care. The VA is no different in …
Marilyn Stern · UNIVERSITY OF SOUTH FLORIDA · 2024 · $470,600 — Project Summary There is an unmet need for interventions that address overweight/obesity in pediatric cancer survivors (PCS) after treatment. Rates of overweight and obesity for off-treatment pediatric cancer survivors (PCS) are higher than in the general pediatric population, ranging from 40% to 5…
Sandeep Burma · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $536,215 — Pediatric glioma is characterized by activation of the MAPK pathway, either through a tandem duplication of the BRAFA locus, or through point mutations (most frequently the V600E mutation). Approximately 1400 new cases of BRAF-activated childhood brain tumors are diagnosed annually in the US. Recent…
Milissa L Kaufman · MCLEAN HOSPITAL · 2024 · $761,347 — Dissociative symptoms in traumatized individuals are common, debilitating, and costly; however, little is known about how its biological mechanisms interact with PTSD treatment. Traumatic dissociation broadly encompasses a range of distinct, yet clinically interrelated symptoms: depersonalization, d…
Patrick Thomas Ellinor · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $705,580 — Project summary Nearly one in three people will have an arrythmia during their lifetime and up to 10% may die of sudden cardiac death. Arrhythmias and sudden cardiac death are heritable and often caused by problems of cardiac conduction or repolarization. Nevertheless, the genetic causes are not wel…
Douglas S Portman · UNIVERSITY OF ROCHESTER · 2024 · $542,080 — ABSTRACT Biological sex, a nearly universal feature of metazoan species, modulates many aspects of animal development and physiology. It can also bring about resistance or susceptibility to numerous neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. Nevertheless, the extent to wh…
KENNETH R COOKE · JOHNS HOPKINS UNIVERSITY · 2024 · $396,709 — Allogeneic blood and marrow transplantation (allo-BMT) is the only curative therapy for many pediatric patients with malignant and non-malignant disorders. Unfortunately, treatment-related complications remain a major barrier to successful outcomes. A multiple organ dysfunction syndrome (MODS) works…
Ajay Sharma · CHAPMAN UNIVERSITY · 2024 · $342,000 — Project Summary/Abstract Graft versus host disease (GVHD) is an immune-mediated condition affecting many organs. It is categorized into acute and chronic subtypes. Eyes are affected in 60-90% of the patients with chronic GVHD resulting in significant visual morbidity. About half of the ocular GVHD …
Saeed F Tavazoie · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $338,430 — Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (TCGA) transcriptome data shows that RBPs, as a group, are significantly more dysregulated in cancer than transcription fa…
Jing Yang · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $345,584 — Breast tumors are often identified by manual palpation due to their apparent “hardness” compared to normal tissue. The presence of a fibrotic focus in breast tumors is associated with a 10-50-fold increase in tissue stiffness and correlates with distant metastasis and poor outcome. Recent studies sh…
Ksenia Gnedeva · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $461,786 — Project Summary The main way in which non-mammalian vertebrates, such as fish, restore sensory hair cells is through proliferation and differentiation of the residual population of supporting cells. In contrast, supporting cells lose the capacity to proliferate postnatally in mammals, and the molec…
George A. O'Toole · DARTMOUTH COLLEGE · 2024 · $224,496 — In this application, we propose continued funding to the Dartmouth Cystic Fibrosis Training Program (DCFTP). Continuing support is sought for a comprehensive, highly interactive, interdepartmental training program with an emphasis on CF basic and translational science. The overall philosophy of the …
BERNARDINO Francesco GHETTI · MAYO CLINIC JACKSONVILLE · 2024 · $3,080,100 — PROJECT SUMMARY/ABSTRACT Development of cognitive problems at any age is devastating, but development of cognitive problems in working-age people with dependents represents a major public health concern. Young-onset Alzheimer's disease (YOAD) is defined as individuals who present before age 65 and l…
David Paul Stirling · UNIVERSITY OF LOUISVILLE · 2024 · $446,778 — Abstract: Neurological outcome after spinal cord injury (SCI) is dependent on the extent of primary injury and the delayed secondary degeneration of spared white matter (WM) and grey matter. Although Ca2+ overload is established as a key mediator of secondary injury, therapeutically targeting extern…
Yanguang Cao · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $392,134 — ABSTRACT Antibody-based therapeutics have grown rapidly over the past two decades. However, many challenges limiting the success of this drug class persist. First, the attrition rate remains high in antibody drug development. Second, many antibody therapeutics exhibit only transient pharmacologic ac…
CHRISTINE M. EISCHEN · THOMAS JEFFERSON UNIVERSITY · 2024 · $355,240 — Summary A prerequisite for tumor development is acquiring resistance to apoptosis. This can be accomplished through multiple mechanisms, but a frequent alteration in human cancers that protects from apoptosis is the overexpression of one or more of the anti-apoptotic BCL2 family members. BCL2 itself…
RAVI BHATIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $403,983 — PROJECT SUMMARY/ABSTRACT Chronic myelogenous leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR- ABL tyrosine kinase. Tyrosine kinase inhibitors (TKI) are effective in inducing remission and prolonging survival in CML patients, but fail to eliminate primitive leukemi…
Christopher James Clarke · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $343,690 — ABSTRACT Doxorubicin (Dox) is a mainstay in the treatment of many cancers yet its utility is limited by cardiovascular toxicity. While multiple mechanisms underlying this cardiotoxicity have been proposed, strategies targeting these pathways have had marginal effects or interfere with anti-cancer ef…
BRENT K. HOLLENBECK · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $94,664 — PROJECT SUMMARY Nearly 35,000 succumb to advanced prostate cancer each year, making it the second leading cause of cancer death among men. The development of oral specialty drugs targeting specific molecules has led to a paradigm shift in which men can receive treatment for their prostate cancer at …
TIMOTHY T HOULE · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $406,662 — Project Summary For the millions of individuals who experience migraine each year, treatment typically consists of reactively treating attacks only after experiencing disruptive pain and secondary symptoms. Because individual migraine attacks are unpredictable to most sufferers, abortive medication…