Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jeffrey T. Heckman · JAMES A. HALEY VA MEDICAL CENTER · 2024 — Many Veterans with lower limb amputation who use prostheses suffer from skin related prosthetic fit issues such as scars. Problematic scars may be managed with surgical excision that can yield a larger, more sensitive scar. Massage and desensitization techniques are also options. These current inter…
DAVID SHEIKH-HAMAD · MICHAEL E DEBAKEY VA MEDICAL CENTER · 2024 — The prevalence of chronic kidney disease (CKD) in the US is rising concomitant with aging of the general population and coexistence of comorbidities such as hypertension and diabetes mellitus. Cardiovascular outcomes, sudden death and overall mortality are worse with advancing CKD. Ischemic kidney i…
Jason H. Mateika · JOHN D DINGELL VA MEDICAL CENTER · 2024 — Sleep disordered breathing (SDB) affects 4-9% of the general population and up to 60 % of the Veteran population. There is also a high prevalence of sleep disordered breathing in patients with subacute and chronic spinal cord injury (SCI), and the frequency of SCI is approximately 3 times greater in…
Diana I Jalal · IOWA CITY VA MEDICAL CENTER · 2024 — Background. Chronic kidney disease (CKD) associates with high morbidity and mortality due to CKD progression and cardiovascular disease (CVD). Blood pressure (BP) lowering reduces the risk of CVD and CKD progression. In spite of the large number of BP medications available, a significant proportion …
GUODONG CAO · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $561,842 — Abstract Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia after Alzheimer’s disease. Although the causes for VCID are not clear, increasing evidence suggests cerebral hypoperfusion is the dominant pathogenic process. Cerebral hypoperfusion causes the death of…
Carina Gronlund · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $596,556 — PROJECT SUMMARY The homes of millions of older Americans do not provide adequate protection from extreme temperatures, due in large part to “energy poverty.” Modifications to homes that increase energy efficiency and improve indoor temperatures may reduce the adverse neuropsychological health impac…
CARL A LATKIN · JOHNS HOPKINS UNIVERSITY · 2024 · $733,662 — Project Summary This resubmission of application R01DA050470 proposes to use innovative approaches to identify “hotspots,” defined as geographic areas in which high rates of HIV or HCV infection, high HIV viral loads, or drug-resistant HIV strains are found. We propose two novel approaches for ident…
Rugang Zhang · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $439,291 — Project Summary ARID1A, encoding a subunit of the SWI/SNF chromatin-remodeling complex, is the most frequently mutated epigenetic regulator across human cancers. Most notably, inactivating mutations in ARID1A occur in ~50% of ovarian clear cell carcinomas (OCCC) and ~30% of ovarian endometrioid carc…
Chinthalapally V. Rao · OKLAHOMA CITY VA MEDICAL CENTER · 2024 — Summary Pancreatic cancer (PC) has the highest mortality of any cancer, with a 5-year survival rate of less than 10%. Despite progress in the development of targeted therapies, the survival rate is still unacceptably low. It is, therefore, important to identify novel therapeutic approaches that coul…
Jerod Skyberg · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $383,747 — Project Summary/Abstract In humans, Brucella spp. can cause a lifelong, debilitating disease, with relapses of undulating fever and other complications even with antibiotic treatment. No vaccines are currently licensed to prevent human brucellosis, and mechanisms underlying the ability of Brucella …
John Harvey Kindred · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — The long-term goal of this proposed career development award (CDA-2) is to accelerate my training and development so that I can establish an independent line of research unraveling the causes and consequences of fatigue and to develop effective evidence-based therapies for fatigue in Veterans with n…
STUART A BATTERMAN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $593,773 — PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local community-prioritized air pollutants; (2) implement components of our scientifically-grounded community-informed Public H…
Gaurav K Varshney · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 2024 · $213,125 — Hearing loss is a highly prevalent and debilitating neurosensory disorder associated with substantially reduced quality of life and overall health. It currently affects 430 million people worldwide; by 2050 this is expected to increase to nearly 2.5 billion and result 1 in 10 people requiring rehabi…
Anna Katherine Hatstat · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $58,813 — Project Summary/Abstract Living cells have evolved intricate mechanisms to detect their environment and transduce signals across biological membranes, inducing responses in organismal behavior. Despite the prevalence of these receptors, our understanding of the discrete mechanisms by which signals a…
Jurgen Bernd Bulitta · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $751,348 — Project Summary/Abstract: Carbapenem-Resistant Enterobacteriaceae (CRE) have been classified as an urgent public health threat in the US and around the globe. New Delhi Metallo-β-lactamases (NDM) producing CRE are particularly concerning as they have rapidly spread worldwide and can efficiently co- …
Kevin O'Connor · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $50,649 — PROJECT SUMMARY/ABSTRACT Therapy resistance is a major barrier to long term remission in pediatric T-cell acute lymphoblastic leukemia (T- ALL). The prognosis for children with relapsed or refractory disease is dismal. Leukemia-initiating cells (L-ICs) regenerate disease upon transplantation into mi…
STUART A BATTERMAN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $653,107 — ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with complex unknown pathogenesis. Recent evidence supports a gene-time-environment hypothesis whereby environmental exposures trigger neurodegeneration when superimposed on a genetic risk profile. Supp…
James Joseph Crowley · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $194,375 — Project Summary In this study we seek to understand how rare genetic variation in all protein coding genes (the exome) influences the risk of developing obsessive-compulsive disorder (OCD). OCD is of major public health importance owing to its profound personal and societal costs. Little is known f…
Amanda L Huff · JOHNS HOPKINS UNIVERSITY · 2024 · $73,653 — Project Summary Pancreatic ductal adenocarcinoma cancer (PDAC) is highly resistant to frontline surgical resection and chemotherapy treatments. Many treatment-resistant cancer types have benefited from immunotherapies that activate cytotoxic anti-tumor T cells against the somatic mutations, or neoan…
Gabriel Nunez · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $390,000 — The NLRP3 inflammasome is a critical platform for the activation of caspase-1 and secretion of biologically active IL-1β and IL-18 in response to bacterial toxins, particulate matter and certain endogenous stimuli. Furthermore, aberrant activation of NLRP3 has been linked to the pathogenesis of seve…