Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Serap AKSOY · YALE UNIVERSITY · 2024 · $816,642 — This application is on Human African Trypanosomiases (HAT), one of the most neglected diseases of sub- Saharan Africa. Despite the anticipated elimination of the gambiense disease by 2030, control in conflict-ridden and remote areas where HAT typically occurs remains challenging. Interruption of the…
Avital Adah Rodal · BRANDEIS UNIVERSITY · 2024 · $463,903 — PROJECT SUMMARY The goal of this proposal is to understand how cellular membrane trafficking machinery controls the packaging and release of extracellular vesicle (EV) cargoes from synapses in vivo. EVs are small membrane-bound vesicles released by numerous cell types, including neurons, carrying ca…
Junsu Kang · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $382,090 — PROJECT SUMMARY/ABSTRACT Adult mammals poorly regenerate injured hearts. In contrast, adult zebrafish possess a remarkable capacity to regenerate damaged hearts. Combined with available genetic tools, this capacity makes zebrafish a powerful system for deciphering the mechanisms underlying heart reg…
PETER B BARKER · JOHNS HOPKINS UNIVERSITY · 2024 · $404,382 — PROJECT SUMMARY Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, free from overlap from other, more abundant compounds. Until recently, spectral- editing techniques have generally focused on measuring individual metabolites …
JO ANNE SIREY · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $572,799 — ABSTRACT In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, we have partnered with senior center stakeholders to simplify Behavioral Activation (BA) to match the skill set of lay volunteers (“Do More, Feel Better…
GYORGY CSORDAS · THOMAS JEFFERSON UNIVERSITY · 2024 · $536,516 — This MPI proposal has the overarching theme that mitochondrial Ca2+ uptake plays dual “ying-yang” roles when the heart is under stress: it ensures that extra energy demands are met under workload stress, while it is the route for Ca2+ overload/toxicity under oxidative stress. The project uses a new …
Jianxin You · UNIVERSITY OF PENNSYLVANIA · 2024 · $362,492 — Project Summary Merkel cell polyomavirus (MCPyV), the most recently discovered tumor virus, can cause a highly aggressive form of skin cancer called Merkel cell carcinoma (MCC). While the incidence of MCC has tripled over the past twenty years, there is no effective therapy for metastatic MCCs, high…
Zhiqiang Lin · MASONIC MEDICAL RESEARCH LABORATORY, INC · 2024 · $624,659 — Cardiomyocytes (CMs) are building blocks and function units of the heart, and their dysfunction or loss is the root of heart failure. Similar with other specialized innate immune cells, CMs have their own innate immune molecular machinery. Ischemic or non-ischemic pathological stress activates CM in…
Michael Borchers · CINCINNATI VA MEDICAL CENTER RESEARCH · 2024 — Despite decades of research, no effective therapies exist to circumvent the irreversible alterations in lung function associated with COPD. Further, complications of COPD arise from acute and chronic exacerbations that amplify ongoing injury and remodeling that increase morbidity and mortality. The …
Jianjun Chen · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $542,055 — PROJECT SUMMARY (ABSTRACT): Title: Targeting FTO to treat acute myeloid leukemia Background: Acute myeloid leukemia (AML) is a major form of leukemia with unfavorable prognosis. With currently available therapies, over 70% of patients with AML cannot survival over five years. Thus, it is urgent to…
Katherine M. Keyes · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $639,429 — Abstract Suicide rates continue to increase in every age group in the United States and in almost every state—in 2016, 44,965 individuals in the US died by suicide. Developing scientifically rigorous surveillance, reporting, and forecasting systems for suicide is essential to craft appropriate publi…
Kelly S Doran · UNIVERSITY OF COLORADO DENVER · 2024 · $347,074 — PROJECT SUMMARY Bacterial meningitis is the most common serious infection of the central nervous system (CNS) and a major cause of death and disability worldwide, especially in children. Although antibiotic therapy has changed bacterial meningitis from a uniformly fatal disease to an often curable o…
Nicholas Navin · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $352,047 — PROJECT SUMMARY Triple-negative breast cancer (TNBC) is an aggressive subtype in which patients display extensive intratumor genomic heterogeneity and frequently (50%) develop resistance to neoadjuvant chemotherapy (NAC) which leads to metastatic disease and death. Due to the absence of hormonal rec…
Kayvan R Keshari · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $668,212 — PROJECT SUMMARY/ABSTRACT While checkpoint inhibitors and chimeric antigen receptor (CAR) T cells undergo widespread investigation as approaches to unleash the immune system’s tumor-targeting abilities, the mechanisms by which these therapies fail is the subject of great debate. In the setting of sol…
Nuo Sun · OHIO STATE UNIVERSITY · 2024 · $522,831 — PROJECT SUMMARY Mitochondrial dysfunction and altered mitochondrial metabolism have been implicated in the development of heart failure (HF). Mitophagy is a specialized autophagic pathway that mediates the lysosome-dependent clearance of damaged mitochondria, and is essential for mitochondrial qual…
Michael Tun Yin Lam · VA SAN DIEGO HEALTHCARE SYSTEM · 2024 — The sleep-immune axis is highly complex, and the negative impact of inadequate sleep on immune dysfunction is well recognized. Unfortunately, sleep disorders are highly prevalent among Veterans; as a result, understanding how sleep influences immune regulation offers novel therapeutic strategies for…
Kavita Radhakrishnan · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $722,583 — PROJECT SUMMARY/ABSTRACT Heart failure (HF) is a growing pandemic; in the U.S., the number of those diagnosed with HF is expected to rise to 8 million with annual costs at $69 billion by 2030. Despite effective interventions to reduce HF morbidity and mortality, vulnerable populations with HF suffer…
JACKY M JENNINGS · JOHNS HOPKINS UNIVERSITY · 2024 · $1,755,125 — Project Summary Sub-Saharan Africa continues to bear a disproportionate burden of the global HIV epidemic. Conducting studies in the most affected areas of the world is critical to the international HIV research agenda. The Johns Hopkins University-Blantyre, Malawi Clinical Trials Unit (JHU Blantyre…
MARIA HAHN · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $779,408 — PROJECT SUMMARY/ABSTRACT Each year, up to 50,000 patients in the United States receive unnecessary thyroidectomies. These unnecessary thyroidectomies are due to difficulties in preoperatively distinguishing benign thyroid nodules from thyroid cancers. In preliminary data, we developed an epigenetic …
Gwenaelle S Geleoc · BOSTON CHILDREN'S HOSPITAL · 2024 · $538,657 — Project summary Hair cells of the inner ear are the primary receptors of the auditory system. They transduce mechanical information, associated with sound waves, into electro-mechanical (outer hair cells) and electro-chemical (Inner hair cells) signals, which lead to amplification of the initial si…