Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MICHAEL S BOYCE · DUKE UNIVERSITY · 2024 · $329,660 — Project Summary/Abstract One third of eukaryotic proteins transit the secretory pathway for sorting to specific locations, including the endoplasmic reticulum (ER), Golgi, plasma membrane or extracellular milieu. Since misdirected proteins cannot function, the secretory pathway is critical for esta…
Rona Yaeger · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $237,941 — Genomic and biochemical studies indicate the central role of ERK signaling as the key driver of colorectal cancer (CRC) proliferation. Yet selective RAF/MEK/ERK pathway inhibitors have been ineffective in the treatment of CRC thus far. We hypothesize that profound ERK inhibition is required to suppr…
DEBABRATA MUKHOPADHYAY · MAYO CLINIC JACKSONVILLE · 2024 · $599,828 — Glioblastoma multiforme (GBM) is associated with poor prognosis due to its highly invasive and drug-resistant phenotype. Recurrence is a common phenomenon in GBM patients due to the presence of chemo- and radio- resistant Brain Tumor-Initiating Cells (BTICs). Consequently, current therapies includin…
Xiaorong Lin · UNIVERSITY OF GEORGIA · 2024 · $188,750 — ABSTRACT The objectives of this exploratory R21 proposal are to identify and characterize an intercellular communication signal that induces biofilm formation in cooperation with quorum sensing in the human fungal pathogen Cryptococcus neoformans. C. neoformans is a basidiomycetous fungus that cause…
Elena Tsoy · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $161,500 — PROJECT SUMMARY / ABSTRACT The U.S. aging population is rapidly becoming more racially and ethnically diverse and addressing persistent disparities in Alzheimer's disease and related dementias (ADRD) diagnosis and care is an urgent research priority. Fundamentally, the causes of these disparities re…
Odessa Addison · BALTIMORE VA MEDICAL CENTER · 2024 — Falls are a leading cause of injurious death and non-fatal injuries in older adults. While fall prevention is a major VA initiative, the current best fall preventions program only reduces falls by ~30% suggesting further research and interventions are needed to reduce fall risk. Decreased lower extr…
Vadim Backman · NORTHWESTERN UNIVERSITY · 2024 · $1,573,684 — Overall: PROJECT SUMMARY Cancer stem cells (CSCs) play a critical role in fostering tumor resistance to therapies and relapse after treatment. This presents a crucial barrier to the development of successful anti-cancer therapeutics. Transcriptional reprogramming and plasticity play a critical role …
Stephanie Gupton · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $380,281 — PROGRAM DESCRIPTION The overarching research goal of my lab is to define cellular and molecular mechanisms mediating cellular shape change. Cellular shape change is a fundamental characteristic of metazoan cells, key to development, physiology, and pathology. The formation and plasticity of neural n…
Aldrin Enrique Molero · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $599,426 — Huntington’s disease (HD) is a deadly neurodegenerative disorder whose pathogenesis remains unknown. The disease is caused by aberrant polyglutamine expansion in Huntingtin (Htt), a pleiotropic protein with essential functions during development. Using genetically modified mouse models to temporally…
Noelle E. Carlozzi · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $504,261 — Abstract Care partners of persons with moderate to severe traumatic brain injury (TBI) are often required to assume a caregiver role, bearing primary responsibility for assisting the person with TBI in physical, mental, financial, and leisure activities. As a result of these new caregiving responsib…
WALTER J. CHAZIN · VANDERBILT UNIVERSITY · 2024 · $435,875 — PROJECT SUMMARY Faithful replication of DNA and response to encounters with aberrant DNA are essential to cell propagation and survival. Our long-term goal is to understand the action of multi-protein DNA replication and damage response machinery at eukaryotic replication forks. Our strategy is to e…
Stephen R. Bowen · UNIVERSITY OF WASHINGTON · 2024 · $577,989 — ABSTRACT Management of patients with metastatic non-small cell lung cancer (NSCLC) requires navigation of an increasingly diverse therapeutic landscape. Although immune checkpoint inhibitors (ICI) of anti-programmed cell death 1 (PD1) and its ligand PDL1, in combination with chemotherapy (chemoICI),…
Terry W Wright · UNIVERSITY OF ROCHESTER · 2024 · $535,156 — Pneumocystis pneumonia (PcP) remains a serious life-threatening respiratory fungal infection of immunocompromised patients, and one of the most common AIDS-defining illnesses in the US and the world. PcP-related mortality rates have changed little over the past two decades, likely due to our inabili…
XUEDONG LIU · UNIVERSITY OF COLORADO · 2024 · $327,603 — Project Summary Technologies to deliver macromolecules across the plasma membrane and bypass endosome degradation are not only instrumental for elucidating gene function but also hold enormous potential for therapeutics. Proteins, nucleic acids, and ribonucleoproteins (RNP) have become indispensable…
PETER Kent JACKSON · STANFORD UNIVERSITY · 2024 · $484,046 — This project focuses on understanding how dietary fluxes from w-3 fatty acids activate the FFAR4 receptor, expressed in primary cilia, in both preadipocytes to trigger adipogenesis and in pancreatic b cells to enhance insulin secretion. The proposal extends from a recent discovery in the Jackson lab…
Mike Henne · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $393,600 — Lipid-storing cells such as adipocytes are essential for maintaining organismal homeostasis, and can efficiently absorb circulating fatty acids (FAs) prior to their storage as triglycerides (TG) in cytoplasmic lipid droplets (LDs). Defects in lipid uptake, storage, or export lead to elevated blood-c…
PAUL F WORLEY · JOHNS HOPKINS UNIVERSITY · 2024 · $555,930 — Project Summary Memory is our most precious possession, yet we remain unable to prevent its loss in neurological diseases. Here we examine a fundamental property of memory, which is its dependence on rapid de novo protein synthesis, and identify pathways that contribute to normal memory and that und…
Matthew C Weston · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $388,000 — Variants in the KCNT1 gene, which encodes a Na+-activated K+ channel, cause several severe childhood epilepsy disorders that are largely refractory to treatment. Previously, pathogenic KCNT1 variants were shown to increase channel current when assayed in non-neuronal cells, leading to the fundamenta…
Deepak Bhere · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $248,997 — ABSTRACT Each year upwards of 14,000 patients are diagnosed with Glioblastoma (GBM), the most malignant form of primary brain tumor. Surgical resection followed by radio and chemotherapies are the treatment options for GBM, but patients generally succumb to the disease. MicroRNAs (miR) are emerging …
Joshua D Chandler · EMORY UNIVERSITY · 2024 · $385,205 — PROJECT SUMMARY / ABSTRACT Current standard of care for cystic fibrosis (CF) does not include drugs unequivocally effective at curbing airway inflammation, in contrast to crucial gains made in correcting defects in the CF transmembrane conductance regulator (CFTR) via highly effective modulator ther…