Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Zaid Abdo · COLORADO STATE UNIVERSITY · 2024 · $720,054 — PROJECT SUMMARY / ABSTRACT Novel recombinant Rotavirus vaccine utilizing the probiotic microorganism Lactobacillus acidophilus Despite the worldwide licensure and availability of two rotavirus vaccines in 2006, it is estimated that rotavirus kills approximately 215,000 children each year. Children u…
Michael R. Farzan · BOSTON CHILDREN'S HOSPITAL · 2024 · $884,320 — eCD4-Ig is a potent and exceptionally broad fusion of the first two domains of CD4 to an antibody Fc domain and a short tyrosine-sulfated coreceptor-mimetic peptide. In rhesus macaques, adeno-associated virus (AAV)-expressed eCD4-Ig mediates consistent and very effective long-term protection against…
Isabella Soreca · VETERANS HEALTH ADMINISTRATION · 2024 — Obstructive Sleep Apnea (OSA) is a sleep disorder characterized by impaired patency of the upper airway during sleep, resulting in numerous brief arousals from sleep and causing significant disability, lost quality of life and premature mortality1. OSA affects approximately 4-6% of the population na…
ADAM JOSEPH BLOOM · WASHINGTON UNIVERSITY · 2024 · $578,847 — Motor axon loss is a cardinal symptom of amyotrophic lateral sclerosis (ALS). Axon loss can be driven by a genetically encoded program in which the axon survival factors NMNAT2 and STMN2 inhibit the activity of the axon destruction factor SARM1. Recent data suggest that this program of axon self-des…
Ann Kutney Lee · VA BOSTON HEALTH CARE SYSTEM · 2024 — Background: With the aging of the Veteran population, the demand for end-of-life (EOL) care, including hospice services, is increasing. VA commits to ensuring that Veterans have access to high-quality hospice in their setting of choice. In addition to home hospice services, VA offers to provide hosp…
Jane N Bolin · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $817,483 — PROJECT SUMMARY Despite a range of therapeutic approaches, chronic musculoskeletal pain (CMP) persists at a high rate, creating a public health burden. Our long-term goal is to increase access and scalability of evidence-based interventions while addressing pain care disparities for rural individua…
Karthik Murugiah · YALE UNIVERSITY · 2024 · $166,188 — PROJECT SUMMARY Percutaneous coronary intervention (PCI) is the most common cardiac procedure with over 650,000 PCI performed annually in the U.S. Post-PCI complications which occur in a significant proportion of patients are associated with an increased risk of morbidity and mortality. Reliable asc…
RICHARD J TEMKIN · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $518,992 — The proposed research is focused on innovative instrumentation that will enable fundamental advances in the field of Dynamic Nuclear Polarization (DNP) NMR at high magnetic fields, making this powerful technique far more readily available and useful to the national and international biomedical resea…
ALESSANDRO VENOSA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $380,122 — Project Summary/Abstract: Pulmonary fibrosis (PF) is a rare degenerative disease characterized by progressive lung stiffening, resulting in death within 3-5 years of diagnosis. Compelling clinical evidence show that mutations of the epithelial cell- specific gene encoding surfactant protein-C (SP-C)…
Shaunna Simmons · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $34,599 — Streptococcus pneumoniae (pneumococcus) are Gram-positive bacteria responsible for 1.6 million deaths globally each year. Available pneumococcal vaccines have reduced efficacy in the elderly, and despite vaccination, S. pneumoniae remain the leading cause of bacterial community-acquired pneumonia in…
Mariah A Hassert · UNIVERSITY OF IOWA · 2024 · $74,284 — PROJECT SUMMARY Seasonal influenza A (IAV) and other airborne viral pathogens such as SARS-CoV-2 represent a substantial burden on global public health. While sterilizing immunity can be attained through neutralizing antibodies, seasonal antigenic drift permits viral evasion of humoral immunity, whi…
Merritt C Maduke · STANFORD UNIVERSITY · 2024 · $473,494 — The CLC (“Chloride Channel”) family encompasses two major ion-transport mechanisms: half of CLC homologs are electrodiffusive ion channels, and half are secondary active transporters that stoichiometrically exchange Cl– for H+. The occurrence of two mechanisms in one family suggests they operate by …
Antonis Rokas · VANDERBILT UNIVERSITY · 2024 · $687,811 — PROJECT SUMMARY Aspergillus fumigatus is a major human fungal pathogen that infects – often killing – hundreds of thousands each year. A few closely related species are also pathogenic but cause fewer infections. In contrast, most other closely related species are not pathogenic. Pathogens have orig…
DUOJIA PAN · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $405,000 — Project Summary / Abstract My long-term scientific goal is to understand the molecular mechanisms that specify retina cell number. Using the compound eye of Drosophila as an experimental model, my laboratory has discovered the Hippo pathway as a central mechanism underlying this process. The core of…
BARRY H HONIG · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $405,000 — Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computational research and develop software tools, with our efforts being guided by a variety of applications of biomedical importa…
Suman Srinivasa · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $840,829 — Project Summary: Heart disease is a leading cause of non-communicable disease-related morbidity and mortality in the well-treated HIV population, and heart failure with preserved ejection fraction (HFpEF) is rising in prevalence. There are no FDA-approved therapeutics directed at HFpEF that effectiv…
Michael Aschner · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $599,412 — PROJECT SUMMARY Methylmercury (MeHg) is a potent neurotoxin affecting both the developing and mature central nervous system with apparent indiscriminate disruption of multiple homeostatic pathways. However, genetic and environmental modifiers contribute significant variability to neurotoxicity assoc…
Qing Zhang · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $406,336 — Project Summary Distinct histone modifications, on N or C-terminal tails, act as a “histone code” to elicit downstream events. Histone subunit post-translational modification (PTM), such as methylation, acetylation and phosphorylation regulates epigenetic regulation and gene expression in diseases s…
John T Serences · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $395,000 — Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional selection and working memory are mediated by persistent changes in the firing rates, or the gain, of visually responsive neuro…
EMILY JOHNSON · SYRACUSE VA MEDICAL CENTER · 2024 — This RR&D CDA2 will support training for Emily M. Johnson, PhD, as a RR&D research psychologist and develop and evaluate a new package of services, Whole Health STEPS (Structured Tiered Engagement with Peer Support). The training goals for this project are to develop skills in (1) designing and eval…