NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mohab M Ibrahim · SOUTHERN ARIZONA VA HEALTH CARE SYSTEM · 2024 — Mild traumatic brain injury (mTBI) is the most common traumatic brain injury affecting military personnel. mTBI is associated with several neurological symptoms that correlate with neuroinflammation. One of the neurological symptoms associated with mTBI is pain. mTBI-induced pain may be challenging …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
VARMAN T SAMUEL · VA CONNECTICUT HEALTHCARE SYSTEM · 2024 — Increased fructose consumption has been implicated in many diseases, including type 2 diabetes, nonalcoholic fatty liver disease and cardiovascular disease. Pharmaceutical companies are designing inhibitors against ketohexokinase (KHK), the primary enzyme for fructose metabolism. Most studies have u…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
MARGARET S LIVINGSTONE · HARVARD MEDICAL SCHOOL · 2024 · $615,600 — Project Summary The goal of the proposed research is to probe object-recognition circuitry in inferotemporal cortex by specific manipulations of early visual experience. In adult humans and monkeys discrete regions of the temporal lobe are specialized for processing particular object categories, suc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jennifer A Lewis · VETERANS HEALTH ADMINISTRATION · 2024 — Personalizing Veteran's Lung Cancer Screening and Diagnosis Lung cancer is the leading cause of cancer-specific mortality in United States, including among Veterans. Annual lung cancer screening with low-dose chest computed tomography (LDCT) in high-risk individuals has been demonstrated to save liv…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mehdi Mollapour · SYRACUSE VA MEDICAL CENTER · 2024 — Over 79,000 people will develop kidney cancer, also known as renal cell carcinoma (RCC), and almost 14,000 patients will die from this disease in the US this year. Risk factors such as tobacco smoking, obesity and exposure to organic solvents, heavy metals, herbicides, and petrochemicals, all play a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rajeev Dhupar · VETERANS HEALTH ADMINISTRATION · 2024 — Deployment related respiratory exposures (DRREs) during the Gulf War are now presumed to be linked to the development of lung cancer and other respiratory diseases. Recently, we employed a unique mouse model of experimental burn pit-type airborne toxin exposures and found that this induced prolonged…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Michael Method · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $638,605 — Project Summary The 5-year overall survival from acute myeloid leukemia (AML) is less than 30%. While some patients are cured with initial induction therapy, most patients relapse, and the expected outcomes in patients with relapsed and refractory (R/R) AML are dismal. For this reason, developing me…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Peter D Reaven · PHOENIX VA HEALTH CARE SYSTEM · 2024 — Summary: Continuous glucose monitoring (CGM) is increasing rapidly in the Veterans Administration Health Care System (VAHCS). Experience with CGM is greatly modifying our concepts of glucose control and our understanding of how to define and achieve optimal glucose goals. Most available data on CGM …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Milky Kohno · PORTLAND VA MEDICAL CENTER · 2024 — Effective treatments for alcohol-use disorder (AUD), especially for women veterans are critically needed, as rates of AUD in women veterans have been steadily increasing. Sex differences in psychosocial and biological risk factors, however, have not been systematically studied in clinical trials for…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tulsi Patel · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $224,100 — PROJECT SUMMARY/ABSTRACT In order to understand neurological diseases, it is essential to identify the affected neuronal cell types, create model systems that accurately recapitulate normal function and disease phenotypes, and develop tools that allow cellular manipulations. Motor neurons in the sp…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Christine E. Marx · DURHAM VA MEDICAL CENTER · 2024 — Background: There is currently a severe dearth of safe, non-habit forming pharmacological interventions for chronic pain disorders, and the clinical need to develop efficacious new therapeutics has never been more urgent. Fueled by the worsening opioid crisis and further exacerbated by the COVID-19 …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Franco Laghi · EDWARD HINES JR VA HOSPITAL · 2024 — Rationale: In COPD, hospital-based pulmonary rehabilitation can improve symptoms, functional status, and quality of life and decrease unscheduled physician visits, emergency room visits, hospitalizations, and possibly, mortality. Despite the well documented efficacy, hospital-based rehab remains ina…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Charles Chiedu Nwaokobia · EVON MEDICS, LLC · 2024 · $1,349,130 — PHASE I/II (FAST/TRACK) ABSTRACT The Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P) is a project to develop an effective, scalable, user-friendly, and home- based neuromodulatory platform for broad-spectrum treatment of c…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Colin B Begg · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $174,571 — ABSTRACT: The rapid accumulation of “big data” has initiated a new model for conducting cancer research and has resulted in a pressing need for a workforce with quantitative skills. To meet this need we used our first NCI R25 funding period to establish the Quantitative Sciences Undergraduate Resear…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
AJAY NMN RANA · JESSE BROWN VA MEDICAL CENTER · 2024 — Project Summary/Abstract: The main focus of research in our group is to understand the underlying molecular mechanisms of pancreatic and breast cancer pathogenesis. The overarching goal of our research is to investigate how the cellular pathways (i.e. circuits) are dysregulated and can lead to uncon…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JOSEPH M TUSCANO · VA NORTHERN CALIFORNIA HEALTH CARE SYS · 2024 — Approximately 33% of adults in the U.S. have used complementary health approaches (NHIS, CDC [4-6]). In doing so, 59 million Americans spend $30.2 billion out-of-pocket/year. The most commonly used complementary approach are natural products ($12.8 billion-almost one fourth of the out-of-pocket amou…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Edward J Lesnefsky · VA VETERANS ADMINISTRATION HOSPITAL · 2024 — Myocardial injury is increased during ischemia and reperfusion in the aged heart and accelerates the transition to post-infarction heart failure. Most therapeutic strategies that effectively decrease cardiac injury in younger hearts fail in aged hearts. Aging causes dysfunctional mitochondria that i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Shanthi K Srinivasan · VETERANS HEALTH ADMINISTRATION · 2024 — Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in veterans and its prevalence continues to increase, with the growing obesity epidemic. Currently more than 25% of our veterans are obese and a larger number are overweight. In this proposal, we will examine the pl…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jun Wu · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $401,357 — The communication between adipose immune cells and neighboring adipocytes has become increasingly appreciated over the past two decades, and its relevance to metabolic disorders such as obesity, insulin resistance and diabetes is now well-recognized. We have recently discovered that acetylcholine-pr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Michael D Sweat · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $461,641 — PROJECT SUMMARY / ABSTRACT Abstract: Despite the vast and ever-growing scientific literature on the efficacy of behavior, social, and structural interventions, interpreting the scientific literature is challenging. Identifying relevant studies is time intensive. The quality of research from publishe…