Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
ARPANA AGRAWAL · WASHINGTON UNIVERSITY · 2019 · $661,450 — A recent CDC report observed that heroin use has increased in men and women across the U.S., including most age groups and all income levels. The current heroin epidemic follows an ongoing prescription opioid misuse epidemic that has helped drive the spike in heroin use. Research to improve understa…
Graham Thomas Dempsey · Q-STATE BIOSCIENCES, INC. · 2019 · $777,880 — Project Summary: Synaptic dysfunction has been implicated in many neurological diseases including epilepsy, Alzheimer’s, Parkinson’s, autism spectrum disorder (ASD), schizophrenia, depression, ADHD and Huntington’s. Despite the prevalence and severity of these disorders, the development of new thera…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2019 · $2,561,973 — UNAIDS has documented millions of new HIV-1 infections every year, thus a vaccine for HIV-1 is highly desirable. To date, despite numerous efforts, no immunization regimen reproducibly elicits broadly neutralizing antibodies (bNAbs) against HIV-1. Recently available native-like HIV-1 envelope spike …
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2019 · $721,207 — DESCRIPTION (provided by applicant): Recently, a novel and highly virulent Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) emerged, causing ~40% mortality rates. MERS-CoV replicates efficiently in humans, camels and bats, but not mouse cells demonstrating a broad yet rodent-restricte…
NATALIE G. AHN · UNIVERSITY OF COLORADO · 2019 · $302,885 — PROJECT SUMMARY An important unsolved question is how extracellular signals lead to force-generating events needed for cell migration. Cell locomotion requires coordination between localized membrane protrusions and matrix attachments at the cell front, and localized retraction and disassembly of ad…
Fang Li · UNIVERSITY OF MINNESOTA · 2019 · $455,796 — Receptor recognition and cell entry by viruses are two initial and essential steps in viral infection cycles. They are important determinants of viral host ranges, tissue tropisms and pathogenesis, and are primary targets for human intervention. Coronaviruses (CoVs) pose serious health threats to hu…
ANDRE ANTONIO FENTON · NEW YORK UNIVERSITY · 2019 · $343,384 — ABSTRACT Full mutation of the FMR1 gene causes loss of the fragile X mental retardation protein (FMRP) and fragile X syndrome (FXS) characterized by intellectual disability with devastating cognitive consequences and features of autism. Study of Fmr1 knockout (KO) mouse models of the FXS genetic def…
Lanying Du · NEW YORK BLOOD CENTER · 2019 · $845,133 — Project Summary Viral subunit vaccines are safe and convenient, but generally suffer low efficacy. Our overall hypothesis is that an intrinsic limitation is associated with subunit vaccine designs in which artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine eff…
Bryce C Chackerian · MASSACHUSETTS GENERAL HOSPITAL · 2019 · $543,444 — Project Summary / Abstract This proposal describes the framework of an R01 grant by Dr. Daniel Lingwood, an Assistant Professor at Harvard Medical School and faculty member of the Ragon Institute of MGH, MIT and Harvard, and Dr. Bryce Chackerian, an Associate Professor in the Department of Molecular…
NATALIE G. AHN · UNIVERSITY OF COLORADO · 2019 · $286,400 — PROJECT SUMMARY An important unsolved question is how extracellular signals lead to force-generating events needed for cell migration. Cell locomotion requires coordination between localized membrane protrusions and matrix attachments at the cell front, and localized retraction and disassembly of ad…
Bradley Joel Undem · JOHNS HOPKINS UNIVERSITY · 2019 · $528,619 — Asthma, COPD, and chronic cough, as with other visceral inflammatory diseases, are characterized by an over-excited sensory nervous system. When airway sensory nerves are dysregulated by inflammation it can lead to excessive coughing, dyspnea, changes in breathing pattern, and reflex bronchospasm an…
Dax A Hoffman · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2019 · $1,780,267 — Isomerase regulation of potassium channel trafficking and function. Kv4.2 channels are key determinants of dendritic excitability and integration, spike timing-dependent plasticity and long-term potentiation. Downregulation of Kv4.2 channel expression occurs following hippocampal seizures and in ep…
ELLIS L REINHERZ · DANA-FARBER CANCER INST · 2019 · $1,289,810 — ABSTRACT There are only a handful of sites on the HIV-1 envelope protein that represent regions of vulnerability for elicitation of broadly neutralizing antibody (BNAbs). Four are associated with the gp120 subunit while one of the sites resides in the membrane proximal external region (MPER) of …
ALLAN I LEVEY · EMORY UNIVERSITY · 2019 · $883,317 — The Open Drug Discovery Center for AD (Open-AD) Structural Biology core aims to provide Target Enabling Packages (TEPs): a combination of experimental tools and knowledge that will allow researchers to investigate the biology of potential drug targets and to test therapeutic hypotheses. The TEPs wil…
Kelly Sabrina Lynn · EMORY UNIVERSITY · 2019 · $45,016 — ABSTRACT Acute respiratory distress syndrome (ARDS) is a serious lung condition characterized by airspace flooding and widespread inflammation. Survival of ARDS is chiefly attributed to the ability to maintain airspace fluid balance. This involves two complimentary processes: sodium-driven fluid cle…
Margaret M Stratton · UNIVERSITY OF MASSACHUSETTS AMHERST · 2019 · $37,952 — PROJECT SUMMARY How does a memory outlast the lifetime of the molecule that encodes it? More than two decades ago, Francis Crick had the foresight to speculate that perhaps a multimeric protein could serve as a molecular memory by sharing its activation state with newly synthesized proteins through …
AMIN S GHABRIAL · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2019 · $335,807 — Ghabrial – Project Summary To build a functional vascular system, a network of endothelial tubes must be generated through a combination of vasculogenesis and angiogenesis. During sprouting angiogenesis, endothelial tip cells lead the outgrowth of new branches. Tip cells anastomose with other tip ce…
Kelly Keisen Lee · UNIVERSITY OF WASHINGTON · 2019 · $396,951 — Enveloped viruses use specialized protein machinery to fuse their membrane with the membrane of host cells and deliver their genetic material for replication. In influenza virus, the trimeric hemagglutinin (HA) glycoprotein spike is responsible for host cell attachment and membrane fusion. The seque…
Helen E Scharfman · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · 2019 · $404,250 — ABSTRACT It has been suggested that neuronal hyperexcitability is an important characteristic in Alzheimer’s disease (AD) because it contributes to the impairment in memory and increasing levels of amyloid β (Aβ) that characterize the disease. Using animal models of AD neuropathology we suggest tha…
MATTHEW C GIBSON · STOWERS INSTITUTE FOR MEDICAL RESEARCH · 2019 · $290,400 — DESCRIPTION (provided by applicant): Mitotic Rounding and Planar Spindle Alignment in Proliferating Epithelia Project Summary During development and homeostasis of multicellular animals, adherent layers of proliferating epithelial cells provide the spatial and structural contet essential for ne…