Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Darla M Castelli · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $689,124 — PROJECT SUMMARY/ABSTRACT Passive sensing of Latina women's daily living experience as proxy measures of health risk must be brought to scale. We propose to validate the integrated measurements from Fitbits, smartphones, purpose-built environmental sensors (Beacon), GPS, and a purpose-built smartpho…
Jesse Gitaka · MOUNT KENYA UNIVERSITY · 2024 · $139,778 — SUMMARY Coronavirus disease of 2019 (COVID-19) and pulmonary tuberculosis (PTB) have been reported as the leading causes of mortality from an infectious disease perspective in 2020. TB disease is caused by infection with Mycobacterium tuberculosis (Mtb), and Kenya remains one of the countries with t…
Jingjing Shang · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $834,479 — The COVID-19 pandemic has disproportionately impacted elderly vulnerable populations (i.e., racial/ethnic minorities and rural residents). The high risk for acquiring COVID-19 and the dire outcomes in these vulnerable populations is partially explained by the high prevalence of comorbidities and oth…
Amanda Burnham-Marusich · DXDISCOVERY, INC. · 2024 · $999,716 — Pertussis (Whooping cough) is a highly contagious, airborne disease that is rapidly re-emerging as a serious public health threat in the United States. Despite high vaccine coverage, annual reported cases in the U.S. have been increasing recently, with an average of 25,000 per year from 2010-2019. T…
Tené T Lewis · EMORY UNIVERSITY · 2024 · $763,431 — PROJECT SUMMARY The novel coronavirus disease 2019 (COVID-19) global pandemic is arguably one of the most devastating Public Health crises of the last century. In the United States, African-Americans have been disproportionately impacted, with overall rates of infection and mortality 2 to 4 times hi…
Corinne E. Joshu · JOHNS HOPKINS UNIVERSITY · 2024 · $776,684 — ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic has had an unprecedented impact on the lives of people worldwide. Yet, the effect on persons living with HIV (PLWH) is not known. Emerging evidence suggests that PLWH have a similar or modestly higher risk of COVID-19 acquisition, and higher …
Dan Jane-Wit · YALE UNIVERSITY · 2024 · $209,375 — PROJECT SUMMARY During severe COVID-19, immune hyperactivation contributes to tissue injury and worsened patient outcomes. Complement (C’) proteins are believed to centrally mediate COVID-19-related immune hyperactivation. C’ are a conserved set of immune proteins involved in host defense that beco…
Chun Chieh Hsu · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $108,000 — PROJECT SUMMARY/ABSTRACT The COVID-19 pandemic has had a devastating worldwide impact on health and economy. There is still no effective treatment, and the full extent of COVID-19 pathogenesis remains unclear. In particular, mechanisms for SARS-CoV-2 evasion of host immune surveillance remain poorl…
MICHAEL LEVITT · STANFORD UNIVERSITY · 2024 · $558,519 — Project Summary (30 lines) With its revised title “Emergent Properties of Complex Systems: From Atoms to Macromolecules; from Humans to Societies” this proposal has been broadened by adding data-analysis & simulation on a problem of grave current concern: namely how an air-borne virus like SARS-2-Co…
Margaret Juliana McElrath · SEATTLE CHILDREN'S HOSPITAL · 2024 · $2,100,000 — ABSTRACT (Overall) Malaria, HIV/AIDS, and Covid are three of the most devastating infectious diseases, impacting millions of people world-wide. Effective vaccines against the pathogens that cause these diseases (HIV, SARS-CoV-2 and Plasmodium falciparum) have proven elusive and/or affected by pathog…
Shweta Bansal · GEORGETOWN UNIVERSITY · 2024 · $426,660 — Project Summary My research program addresses fundamental questions about population-scale infectious disease dynamics and brings to light the role of social factors in these dynamics. The impact that carefully formulated and extensively validated models can have in predicting spatio-temporal diseas…
KRZYSZTOF A FIDELIS · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $638,990 — PROJECT SUMMARY Experimental determination of protein structure often provides atomic accuracy models, but is inherently time- consuming, often costly, and not always possible. Computational modeling is currently less accurate, but offers an alternative approach when experimental results are not av…
BENJAMIN JOACHIM SCHMIEDEL · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2024 · $274,500 — PROJECT SUMMARY/ABSTRACT The clinical presentation of SARS-CoV-2 infection in humans can range from very mild or no symptoms to severe respiratory failure. Although hyperactivation of various cellular components of the immune system have been observed in patients with severe COVID-19 illness, the ho…
Marielena Lara · RAND CORPORATION · 2024 · $591,567 — Racial and ethnic minorities with chronic illness suffer disproportionately from infectious diseases. Analysis of COVID-19 and influenza data suggest multiple determinants of vaccination inequities among non-Hispanic whites and other racial/ethnic groups. These include manifestations of structural r…
TARA AUSTIN · VA SAN DIEGO HEALTHCARE SYSTEM · 2024 — 2-8% of the US population report “long COVID” symptoms – including “brain fog,” thinking difficulties, memory problems, and psychiatric symptoms such as sleep disturbance, anxiety, and depression. Rates of post- COVID-19 symptoms are nearly double in the Veteran population. These cognitive symptoms …
WEN-YUAN E HSIEH · UNIVERSITY OF COLORADO DENVER · 2024 · $604,346 — PROJECT SUMMARY Emergence of the highly transmissible SARS-CoV-2 B.1.617.2 (Delta) variant and return to in-person learning is rapidly increasing the COVID-19 disease incidence and transmission rate in children. Therefore, it is critical to protect younger children. Toward this goal, ongoing COVID-1…
Lael Yonker · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $828,233 — Over 15.6 million children in the U.S. alone have been infected by SARS-CoV2. While most recover, roughly 1 million children suffer from Long COVID. Neutrophils have been shown to be hyperactivated in Long COVID, which is concerning because they can be quite inflammatory, causing vascular and tissue…
Luana Colloca · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $614,581 — Summary The COVID-19 pandemic and its effect on the opioid crisis have created a pressing need for telemedicine and consideration for use of non-pharmacological, low cost interventions as adjuvants in pain management arsenal. We propose a project investigating neural mechanisms underlying pain reduc…
GEOFFREY M CURRAN · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $569,232 — PROJECT SUMMARY The COVID-19 pandemic has disproportionally impacted rural communities, which are often health professional shortage areas that lack health care infrastructure, including hospitals1-3. When compared to urban populations, individuals living in rural areas are more vaccine hesitant8,9,…
DJENEBA BOCAR FOFANA · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · 2024 · $100,040 — SUMMARY Human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) share the same blood borne modes of transmission, primarily through sexual contact and injection drug use and individuals at risk for HIV are also at higher risk for HBV infection. Globally, an estimated 257 million people live w…