Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Peng Li · WEST VIRGINIA UNIVERSITY · 2024 · $526,400 — Abstract/Summary Despite the nearly 4 decades of technology development for biomolecular structure analysis since the discovery of the ribozyme, researchers still grapple with an inability to characterize important intermediates and other aspects of functional nucleic acid structure. Although powerf…
Joshua Kennedy · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2024 · $694,403 — PROJECT SUMMARY Respiratory viral coinfections (RVCIs) are more common in children than adults and have become increasingly important due to the emergence of SARS-COV-2. However, the distinction between coinfection and codetection remains unclear. Further, the association between finding multiple vi…
JANKO Z. NIKOLICH · UNIVERSITY OF ARIZONA · 2024 · $2,615,632 — OVERALL- Abstract Infectious disease, cancer, and autoimmune disorders affect hundreds of millions of older adults. They reduce length and quality of life across the globe and inflict a massive economic burden on society, as vividly exemplified by the SARS-CoV-2 pandemic, that has claimed 93.1% of …
Scott Dryden-Peterson · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $367,640 — Project Summary / Abstract Successful HIV treatment programs in Botswana and elsewhere in southern Africa have led to dramatic reductions in mortality from tuberculosis, cryptococcosis, and other non-cancer AIDS deaths. However, cancer deaths have not decreased, and cervical cancer now is the leadin…
WILLIAM Robert JACOBS · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $786,783 — Project Summary Despite broad availability and extensive use of the vaccine Bacille Calmette Guerin (BCG) and sterilizing chemotherapies, tuberculosis (TB) remains responsible for more than 1.5 million deaths annually. Although COVID-19 caused more deaths than TB in 2020 and 2021, TB is expected to …
Chun-Teng Huang · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2024 · $594,187 — PROJECT SUMMARY Sanford Burnham Prebys Medical Discovery Institute (SBP) has 40 research labs specializing in cancer, children’s health, stem cells, degenerative diseases of aging, as well as infectious and other diseases. Many recent advances in medical research and healthcare rely on the discovery…
Donglin Zeng · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $396,020 — PROJECT SUMMARY In epidemiological cohort studies, the onset of an asymptomatic disease (e.g., diabetes, hypertension, chronic obstructive pulmonary disease, HIV infection, SARS-CoV-2 infection, cancer, or dementia) cannot be observed directly but rather is known to occur sometime between two consec…
STEPHAN K SCHWANDER · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $519,900 — Air pollution and tuberculosis (TB) represent two of the most devastating and life-threatening global public health problems. With hundreds of million persons living in urban slums worldwide, vulnerable, marginalized and hard- to-reach populations are most affected by indoor and outdoor air pollutio…
Susan L Swain · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $209,375 — ABSTRACT: Harnessing Age-Associated B Cells for a Universal Influenza Vaccine for the Aged. With age, the generation of T follicular helpers from naive CD4 T cells, and germinal center B cells from follicular B cells, that are both needed for the generation of high affinity antibody (Ab), become hig…
SARAH E. F. D'ORAZIO · UNIVERSITY OF KENTUCKY · 2024 · $18,000 — This proposal requests 2 years of support for the Autumn Immunology Conference (AIC), an annual gathering of immunologists at the Marriott Downtown Magnificent Mile hotel in Chicago, IL. Year 1 will support the 50th annual AIC on November 18-21, 2022 and Year 2 will support the 51st annual meeting t…
KEVIN O SAUNDERS · DUKE UNIVERSITY · 2024 · $4,794,780 — ABSTRACT – OVERALL HIV-1 broadly neutralizing antibodies (bnAbs) are protective in animal models of HIV-1 infection, but are not elicited in humans by current vaccine regimens. To elicit bnAbs, the B cell lineage vaccine design approach aims to administer multiple immunogens in a specific sequence t…
MATTHEW L MACIEJEWSKI · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · 2024 — Background. Social factors exert a substantially more potent impact on health than does health care, especially among disadvantaged populations such as VA users. Adverse social determinants of health (SDH)—factors such as housing instability, food insecurity, social isolation, and transportation bar…
Kirsten Anne Koehler · JOHNS HOPKINS UNIVERSITY · 2024 · $803,850 — The Children's Environmental Health Research Centers have made significant contributions to defining environmental risk factors and developing interventions to reduce risk. Successful translation of this work has the potential to amplify discovery to improve the lives of millions of infants and chil…
Saad J. Kenderian · MAYO CLINIC ROCHESTER · 2024 · $600,395 — PROJECT SUMMARY Despite the impressive activity of chimeric antigen receptor (CART) T cell therapy in the treatment of B-cell malignancies, the therapy is limited by the development of cytokine release syndrome (CRS) and neurotoxicity, as well as by lower rates of durable responses. While CRS is rel…
Carine Nkemngong · HALOMINE, INC. · 2024 · $743,507
Beverly H Koller · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $194,375 — Summary The cell and tissue tropism of viruses is defined as the capacity of a virus to infect specific cells and tissues and is determined by both viral and cellular factors. An important factor for initiation of infection is cell entry, which is dependent on the ability of the virus to dock with i…
Sagar D Khare · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $187,992 — The ongoing rapid and widespread transmission of SARS-CoV-2 across the world has resulted in myriad viral strains, but human immunity has been acquired from vaccination against a single (Wuhan-Hu-1) strain and/or previous infection with a handful of strains. The large number of substitutions present…
Thomas Michael Sabo · UNIVERSITY OF LOUISVILLE · 2024 · $324,282 — An ongoing debate concerns the role conformational motions, often termed dynamics, play in biomolceular funtion. For enzymes, it so happens that the timescales for large-scale domain motions are similar to the apparent "$$). catalytic rate (𝑘!"# This observation is where the major point of contenti…
Michael S Cohen · UNIVERSITY OF KANSAS LAWRENCE · 2024 · $186,159 — PROJECT SUMMARY Coronaviruses (CoVs) are a large class of positive-strand RNA viruses that are capable of causing severe human disease and death, as is exemplified by the pandemic outbreak of SARS-CoV-2. The innate immune response to coronavirus infection includes a battle between poly-ADP-ribose po…
JENNIFER A PHILIPS · WASHINGTON UNIVERSITY · 2024 · $609,027 — SUMMARY The goal of this project is to understand how two virulence factors from Mycobacterium tuberculosis (Mtb), CpsA and phthiocerol dimycocerosate (PDIM), impair immunity by undermining both classical and non-classical autophagy. Mtb is the causative agent of tuberculosis (TB), the leading cause…