Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Emily R Troemel · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $386,805 — Project Summary/Abstract RNA viruses have had an immense impact on human health. SARS-CoV-2 is only the most recent of many RNA viral zoonoses, and, even disregarding pandemics, the health burden of endemic RNA viruses, particularly in vulnerable populations, is substantial. Epithelial cells, abunda…
DAVID J. STEWART · COLD SPRING HARBOR LABORATORY · 2024 · $1 — PROJECT SUMMARY This proposal seeks support for the conference on Network Biology, to take place March/April 2021 to 2025, at the Cold Spring Harbor Laboratory (CSHL). This meeting, held in biannual rotation on the CSHL campus in New York, brings together senior and junior scientists from both exper…
Deborah F Kelly · WAKE FOREST UNIVERSITY · 2024 · $458,225 — PROJECT SUMMARY/ABSTRACT (DESCRIPTION): RNA viruses can be devastating human pathogens that impart large medical and economic burdens to society (e.g., SARS-CoV-2, influenza A virus, Ebola virus, rotavirus, etc.). While these viruses can differ quite dramatically in their pat…
ANA Patricia ORTIZ · COMPREHENSIVE CANCER CENTER/ UNIV/PR · 2024 · $431,990 — Project Summary. Research performed in Puerto Rico (PR) provides an opportunity to advance knowledge of cancer risk, and cancer prevention and control among Hispanic and non-Hispanic populations in the United States (US). Since 2019, the Cancer Prevention and Control (CAPAC) Research Training Progra…
Sanjana Dayal · UNIVERSITY OF IOWA · 2024 · $673,720 — Project Summary Infection with severe acute respiratory syndrome novel corona virus (SARS-CoV-2) causes COVID-19. In severe cases, COVID-19 leads to profound inflammation (“cytokine storm”) followed by coagulopathy and a prothrombotic-state with progression to multiple organ failure. Several cytokin…
Gregory David Ebel · COLORADO STATE UNIVERSITY · 2024 · $449,212 — Arthropod-borne viruses (arboviruses) adapt to local conditions, maximizing their potential to perpetuate and emerge as health threats. The adaptive potential of arboviruses is driven by error-prone replication, which creates a genetically diverse pool of competing virus genotypes within each host. …
Margo A Brinton · EMORY UNIVERSITY · 2024 · $790,410 — Project Summary Flaviviruses are vector-borne, positive-stranded RNA viruses that emerge unexpectedly and cause a spectrum of potentially severe diseases including hepatitis, vascular shock syndrome, encephalitis, paralysis, and congenital abnormalities. During the last 70 years, Dengue (DENV), West…
ANDREW P LANE · JOHNS HOPKINS UNIVERSITY · 2024 · $653,305 — Project summary: The olfactory epithelium is situated in the nasal passages at the interface with the environment – a location that makes it vulnerable to damage by both infectious and non-microbial threats. While the innate immune defenses of the respiratory epithelium are increasingly well underst…
Haitao Hu · RNA THERAPEUTICS INC. · 2024 · $299,967 — ABSTRACT The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), has impacted global public health in an unprecedented manner. Vaccination is considered one of the most effective countermeasures against infectious diseases, including COVID-19…
Babbette LaMarca · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $501,050 — Preeclampsia (PE) a disease estimated to affect 12% of deliveries at University of Mississippi Medical Center. The incidence of PE deliveries increased significantly at our hospital due to the COVID-19 pandemic. The rate of PE at UMMC rose from 12% to 28% in December of 2020 and was up to 42 % in Ap…
SANCY ANN LEACHMAN · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $30,000 — PROJECT SUMMARY The Montagna Symposium on the Biology of Skin has gathered nearly annually for 70 years with the goal of bringing together leading scientists and clinical investigators in a uniquely designed conference to drive forward the field of skin biology. Through cutting edge presentations an…
William John Zacharias · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $569,920 — PROJECT SUMMARY The alveolar region of the mammalian lung is a complex, precisely structured tissue required for the primary functions of the respiratory system, gas exchange and tissue oxygenation. Damage to the alveolar epithelium plays a central role in human lung diseases including Acute Respira…
Gabriel D Victora · ROCKEFELLER UNIVERSITY · 2024 · $628,257 — PROJECT SUMMARY Generating an appropriate antibody response is critical for protection against reinfection and for the effectiveness of vaccination, particularly in the context of viral diseases. In addition to well-studied quantitative parameters such as antibody titer and affinity, other, more qua…
ADRIANA WEINBERG · UNIVERSITY OF COLORADO DENVER · 2024 · $704,735 — Project Summary People with immunocompromising conditions, including end stage renal disease (ESRD) and renal transplantation, are at increased risk of developing severe infections. Vaccination is the preferred mode of protection against infections but people with the highest risk of infectious morb…
Tim Lautenschlaeger · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $316,620 — ABSTRACT, Clinical Protocol and Data Management (CPDM) The Indiana University Simon Comprehensive Cancer Center (IUSCCC) Clinical Trials Office (CTO) provides the clinical research infrastructure to support IUSCCC investigators and enhance their clinical research productivity. The CTO provides compr…
Sara J Knight · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 — Background: An estimated 10-50% of patients with a history of COVID-19 infection (C+) experience PASC. PASC presents as a multisystem syndrome, with symptoms ranging in severity and regularity that can last weeks to months after acute infection. These symptoms can lead to mild to severe functional l…
LISHAM ASHRAFIOUN · VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF · 2024 — Background: Loneliness—a subjective emotional state characterized by the perception of social isolation—is a psychosocial factor that is associated with increased mortality, substance use, and is associated with precipitants of relapse among individuals with substance use disorders (SUD). Importantl…
ELIZABETH J SANTA ANA · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — Justification: High inpatient readmissions among Veterans with SUDs constitutes a costly and persistent healthcare problem. VHA Handbook 1160.06 guides the development and implementation of recovery-oriented mental health (MH) services, although significant service gaps remain on VA inpatient settin…
Daniel E. Forman · VETERANS HEALTH ADMINISTRATION · 2024 — Cardiac rehabilitation (CR) is an evidence-based secondary prevention program for patients with cardiovascular disease (CVD) that aims to stabilize patients clinically and to restore physical function and health after a CVD event. It is well-suited to the needs of the aging Veterans Health Administr…
ANOUK L GRUBAUGH · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — Background: Severe mental illnesses are consistently ranked as some of the most debilitating health conditions worldwide due to their early age of onset, chronicity, and impact on functioning. Fortunately, a number of antipsychotic medications have been found to be effective for managing the symptom…