Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
KATHLEEN A GRIFFITH · BALTIMORE VA MEDICAL CENTER · 2024 — Findings of post-acute sequelae of Post-COVID Conditions (PCC) manifestations of fatigue, pain, dyspnea, and muscle weakness, provide a strong rationale for rehabilitation; yet few formal studies exist and the effects of severe acute respiratory syndrome coronavirus-2 infection on function are not w…
Lok-Yin Roy Wong · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $248,999 — Project summary/Abstract SARS-CoV, MERS-CoV and SARS-CoV-2 belong to the genus Betacoronavirus and encode sets of specific accessory proteins. Accessory proteins encoded by coronaviruses are not essential for the viral life cycle but are important regulators that mediate immune evasion for optimal v…
ELEFTHERIOS P DIAMANDIS · SINAI HEALTH SYSTEM · 2024 · $228,042 — R21 Project summary abstract Alzheimer’s disease is a serious neurodegenerative disorder affecting millions of people. Currently there are no effective therapies and the reliance on managing the disease depends on accurate diagnosis and assessment of progression. In our grant application we aim to i…
Rafia Virk · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $40,583 — PROJECT SUMMARY Significance. Pulmonary inflammation, which contributes toward the severity of lung diseases, is markedly exacerbated by obesity. Thus, there is a need for novel therapeutic approaches for targeting pulmonary inflammation in obesity. One promising strategy involves increased dietary …
Behnood Gholami · AUTONOMOUS HEALTHCARE, INC. · 2024 · $54,997 — The US opioid crisis continues to have a catastrophic impact on human lives and the ongoing COVID-19 pandemic is compounding its effects. Based on the statistics published by the CDC, 91,799 drug overdose deaths occurred in the US in 2020, where the age-adjusted overdose deaths increased by 31% from…
Neeraj Chhabra · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $199,260 — Project Summary/Abstract Patients with opioid misuse disproportionately utilize emergency health services and are at increased risk for premature death. The timely and accurate identification of patients with opioid misuse in the Emergency Department (ED) is critical to provide evidence-based interv…
KENNETH E PALMER · UNIVERSITY OF LOUISVILLE · 2024 · $2,667,645 — SUMMARY (OVERALL): The University of Louisville Regional Biocontainment Laboratory (RBL) is operated by the University Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The RBL is a regional resource that facilitates translational research to develop diagnostics, …
Rishi Kumar Wadhera · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $644,279 — PROJECT SUMMARY/ABSTRACT More than 34 million people experience food insecurity in the US, and 1 in 3 households with low incomes are food insecure. A growing body of evidence suggests that food insecurity is associated with higher rates of cardiovascular disease and mortality. Therefore, efforts to…
PHILIP SCUMPIA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · 2024 — Despite improvements in non-invasive medical imaging to aid in the diagnosis of internal malignancy, improvements in imaging the skin non-invasively have been slower. The dermatoscope, a device that gives a magnified and polarized view of the skin, is the only ancillary tool commonly used for clinic…
Eric Steven Kirkendall · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $1,019,879 — PROJECT SUMMARY Clinical decision support (CDS) systems were developed to improve the quality and safety of medical practice. At present, however, these systems are generally not tied to clinical outcomes, decreasing their effectiveness. Additionally, CDS is often built one institution at a time, so…
MATTHEW TIRRELL · UNIVERSITY OF CHICAGO · 2024 · $781,063 — Project Summary This R01 proposal outlines a research plan which uses targeted nanomedicine to enhance disease- modifying molecular mechanisms both in the acute injurious phase and in the subsequent chronic fibrotic phase of viral-induced pneumonitis. The overall goal of this proposal is to use nan…
Jaimie Meyer · YALE UNIVERSITY · 2024 · $691,541 — Problem: There is urgent need to reach women involved in criminal justice (WICJ) for lifesaving, evidence-based PrEP and medications for OUD (MOUD), using innovative healthcare delivery models that surmount existing social and structural barriers to engagement. Purpose: We use our newly validated de…
Thomas F Scherr · VANDERBILT UNIVERSITY · 2024 · $595,414 — PROJECT SUMMARY Schistosomiasis is endemic in 54 countries and infects nearly 240 million people worldwide per year. Sub- Saharan Africa endures a disproportionate burden, accounting for over 90% of infections. In Kenya, the site of our study, 17 million out of the nation’s 50 million citizens are a…
Paola Gilsanz · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $3,627,096 — The KHANDLE (Kaiser Healthy Aging and Diverse Life Experiences [2R01AG052132-06] Study initiated in 2017 is a lifecourse cohort study of disparities in cognitive ageing and Alzheimer's disease and related dementias (ADRD) in diverse elderly individuals. KHANDLE is one of the largest lifecourse cohor…
Ethel Cesarman · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $448,897 — Abstract: Despite the irreplaceable contributions of physician-scientists to clinical, the pipeline of clinician-scientist trainees remains on the decline. A critical barrier to the physician-scientist career is the lack of protected time and access to research mentorship available to physicians dur…
Antonella Casola · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $200,000 — PROJECT SUMMARY/ABSTRACT Several viruses have been shown to induce metabolic reprogramming of host cells to establish productive infections. One common mechanism utilized by viruses is the stabilization of hypoxia-inducible-factors (HIF). The HIF complex, comprised of an inducible α subunit (HIF-1α …
Eva de Alba Bastarrechea · UNIVERSITY OF CALIFORNIA, MERCED · 2024 · $183,186 — PROJECT SUMMARY/ABSTRACT Multiprotein complexes known as inflammasomes form in innate immune cells to trigger inflammation upon detection of pathogens or tissue damage. Abnormal inflammasome activation leads to chronic inflammation, which is the culprit of numerous life-threatening diseases such as …
Leah M. Frerichs · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $577,297 — Project Summary/Abstract Colorectal cancer (CRC) screening is one of the most effective tools to reduce cancer morbidity and mortality. Yet, CRC screening rates at federally qualified health centers (FQHCs) in rural areas lag behind more well- resourced healthcare systems and national goals. Improvi…
Gary E Gilbert · VA BOSTON HEALTH CARE SYSTEM · 2024 — Blood coagulation enzymes function efficiently only on membranes containing phosphatidylserine. However, phosphatidylserine is not ordinarily available because blood cells sequester it on the interior of cell membranes. Blood platelets respond to collagen in injured tissue, exposing abundant phospha…
Miao Feng · NATIONAL OPINION RESEARCH CENTER · 2024 · $655,424 — Using Innovative Machine Learning to Detect Organized Support and Opposition to E-cigarette Use Prevention Campaign Messaging on Twitter and TikTok In recent years sharp increases in the consumption of non-cigarette tobacco products, including vaping products or electronic nicotine delivery systems…